Computational study of lipid-destabilizing protein fragments: Towards a comprehensive view of tilted peptides

Proteins: Structure, Function and Genetics

Volumn 44, Issue 4, 2001, Pages 435-447

  Lins, L ^a   Charloteaux, B ^b   Thomas, A ^a   Brasseur, R ^b  

^a INSERM   (France)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Hydrophobicity; Lipid destabilization; Lipid interacting peptides; Molecular modeling; Tilted peptides

Indexed keywords

LIPID; PROTEIN;

ARTICLE; CALCULATION; HYDROPHOBICITY; LIPID BILAYER; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN LIPID INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; COMPUTER SIMULATION; HUMANS; LIPID BILAYERS; LIPID METABOLISM; LIPIDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MONTE CARLO METHOD; PEPTIDE FRAGMENTS; PROTEINS; THERMODYNAMICS; WATER;

EID: 0035451179     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.1109     Document Type: Article

References (39)

1. Differentiation of lipid-associating helices by use of 3-dimensional molecular hydrophobicity potential calculations
2. Peptides in membranes: Tipping the balance of membrane stability
3. Tilted peptides: A motif for membrane destabilization (hypothesis)
4. Theoretical and functional analysis of the SIV fusion peptide
5. Fusogenic segments of bovine leukemia virus and simian immunodeficiency virus are interchangeable and mediate fusion via oblique insertion in the lipid bilayer or their target cells
6. Fusogenic activity of SIV (simian immunodeficiency virus) peptides located in the GP32 NH2 terminal domain
7. Correlation between fusogenicity of synthetic modified peptides corresponding to the NH2-terminal extremity of the SIV GP32 and their mode of insertion into the lipid bilayer: An infrared spectroscopy study
8. The C-terminal helix of human apo AII promotes the fusion of unilamellar liposomes and displaces apo A-I from high-density lipoproteins
9. Contribution of the hydrophobicity gradient of an amphipathic peptide to its mode of association with lipids
10. Prediction of signal peptide functional properties: A study of the orientation and angle of insertion of yeast invertase mutants and human apolipoprotein B signal peptide variants
11. Are amphipathic asymmetric peptides ubiquitous structures for membrane destabilisation?
12. Fusogenic properties of the C-terminal domain of the Alzheimer beta-amyloid peptide
13. The 118-135 peptide of the human Prion protein promotes the fusion of unilamellar liposomes together with amyloid fibril formation
14. Membrane disruption by Alzheimer β-amyloid peptides mediated through specific binding to either phospholipids or gangliosides. Implication for neurotoxicity
15. Transmissible and genetic prion diseases share a common pathway of neurodegeneration
16. Two conformational states of amyloid beta-peptide: Implications for the pathogenesis of Alzheimer's disease
17. IMPALA: A simple restraint field to simulate the biological membrane in molecular structure studies
18. Molecular modeling of the amphipathic helices of the plasma apolipoproteins
19. TAMMO: Theoretical analysis of membrane molecular organisation
20. Human lipoprotein-lipase: The loop covering the catalytic site is essential for interaction with lipid substrates
21. Point mutagenesis of carboxy-terminal amino acids of cholesteryl ester transfer protein. Opposit faces of an amphipathic helix important for cholesteryl ester transfer or for binding neutralizing antibody
22. Oblique membrane insertion of viral fusion peptide probed by neutron diffraction
23. Nuclear magnetic resonance investigation of the interactions with phospholipids of an amphipathic α-helix-forming peptide of the apolipoprotein class
24. The thermodynamics of lipid-protein association and the activation of LCAT by synthetic lipopeptides
25. Phospholipid binding and lecithin-cholesterol acyltransferase activation properties of apolipoprotein A-I mutants
26. Apolipoprotein E: Phospholipid binding studies with synthetic peptides from the carboxyl terminus
27. Molecular determinants of the interaction between the C-terminal domain of Alzheimer b-amyloid peptide and apolipoprotein E a-helices
28. Bee and wasp venoms
29. Melittin induces fusion of unilamellar phospholipid vesicles
30. Conformation and dynamics of melittin bound to magentically oriented lipid bilayers by solid-state 31P and 13C NMR spectroscopy
31. Stability of a melittin pore in a lipid bilayer: A molecular dynamics study
32. Lecithin cholesterol acyltransferase
33. LCAT in the metabolism of high density lipoproteins
34. What studies of fusion peptides tell us about viral envelope glycoprotein-mediated membrane fusion
35. The helical hydrophobic moment: A measure of the amphiphilicity of the α-helix
36. Practical aspects of computational chemistry calculations through PC networks: The RAMSES-Beowulf implementation
37. Pex, analytical tools for PDB files I. GF-Pex: Basic file to describe a protein