The human Cut homeodomain protein can repress gene expression by two distinct mechanisms: Active repression and competition for binding site occupancy

Molecular and Cellular Biology

Volumn 16, Issue 10, 1996, Pages 5346-5357

  Mailly, France ^a   Bérubé, Ginette ^a   Harada, Ryoko ^a   Mao, Pei Lin ^a   Phillips, Sherlyn ^a   Nepveu, Alain ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL SPECIFICITY; CONTROLLED STUDY; DNA FOOTPRINTING; DOWN REGULATION; ELECTROPHORETIC MOBILITY; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN;

ANIMALIA; DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER;

EID: 0029834445     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.10.5346     Document Type: Article

References (71)

1. Andres, V., M. D. Chiara, and V. Mahdavi. 1994. A new bipartite DNA-binding domain: cooperative interaction between the cut repeat and homeo domain of the cut homeo proteins. Genes Dev. 8:245-257.
2. Andres, V., B. Madal-Ginard, and V. Mahdavi. 1992. Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development. Development 116:321-334.
3. Asselin, C., A. Nepveu, and K. B. Marcu. 1989. Molecular requirements for transcriptional initiation of the murine c-myc gene. Oncogene 4:549-558.
4. Aufiero, B., E. J. Neufeld, and S. H. Orkin. 1994. Sequence-specific DNA binding of individual Cut repeats of the human CCAAT displacement/Cut homeodomain protein. Proc. Natl. Acad. Sci. USA 91:7757-7761.
5. Austin, R. J., and M. B. Biggin. 1995. A domain of the even-skipped protein represses transcription by preventing TFIID binding to a promoter: repression by cooperative blocking. Mol. Cell. Biol. 15:4683-4693.
6. Barberis, A., G. Superti-Furga, and M. Busslinger. 1987. Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter. Cell 50:347-359.
7. Blochlinger, K., R. Bodmer, J. Jack, L. Y. Jan, and Y. N. Jan. 1988. Primary structure and expression of a product from Cut, a locus involved in specifying sensory organ identify in Drosophila. Nature (London) 333:629-635.
8. Blochlinger, K., R. Bodmer, J. W. Jack, L. Y. Jan, and Y. N. Jan. 1990. Patterns of expression of Cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos. Genes Dev. 4:1322-1331.
9. Blochlinger, K., L. Y. Jan, and Y. N. Jan. 1991. Transformation of sensory organ identity by ectopic expression of Cut in Drosophila. Genes Dev. 5:1124-1135.
10. Blochlinger, K., L. Y. Jan, and Y. N. Jan. 1993. Postembryotic patterns of expression of Cut, a locus regulating sensory organ identify in Drosophila. Development 117:441-450.
11. Bodmer, R., S. Barbel, S. Shepherd, J. W. Jack, I. Y. Jan, and Y. N. Jan. 1987. Transformation of sensory organs by mutations of the cut locus of Drosophila melanogaster. Cell 51:293-307.
12. Briggs, M. R., J. T. Kadonaga, S. P. Bell, and R. Tjian. 1986. Purification and biochemical characterization of the promoter-specific transcription factor, Sp1. Science 234:47-52.
13. Bunker, C. A., and R. E. Kingston. 1994. Transcriptional repression by Drosophila and mammalian polycomb group proteins in transfected mammalian cells. Mol. Cell. Biol. 14:1721-1732.
14. Catron, K. M., H. Zhang, S. C. Marshall, J. A. Inostroza, J. M. Wilson, and C. Abate. 1995. Transcriptional repression by Msx-1 does not require homeodomain DNA-binding sites. Mol. Cell. Biol. 15:861-871.
15. Chodosh, L. A., A. S. Baldwin, R. W. Carthew, and P. A. Sharp. 1988. Human CCAAT-binding proteins have heterologous subunits. Cell 53:11-24.
16. Chodosh, L. A., J. Olesen, S. Hahn, A. S. Baldwin, L. Guarente, and P. A. Sharp. 1988. A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable. Cell 53:25-35.
17. Cowell, I. G. 1994. Repression versus activation in the control of gene transcription. Trends Biochem. Sci. 19:38-42.
18. Cowell, I. G., and H. C. Hurst. 1994. Transcriptional repression by the human hZIP factor E4BP4: definition of a minimal repression domain. Nucleic Acids Res. 22:59-65.
19. DesJardins, E., and N. Hay. 1993. Repeated CT elements bound by zinc finger proteins control the absolute and relative activities of the two principal human c-myc promoters. Mol. Cell. Biol. 13:5710-5724.
20. Dorn, A., J. Bollekens, A. Staub, C. Benoist, and D. Mathis. 1987. A multiplicity of CCAAT box-binding proteins. Cell 50:863-872.
21. Dufort, D., M. Drolet, and A. Nepveu. 1993. A protein binding site from the murine c-myc promoter contributes to transcriptional block. Oncogene 8:165-171.
22. Dufort, D., and A. Nepveu. 1994. The human cut homeodomain protein represses transcription from the c-myc promoter. Mol. Cell. Biol. 14:4251-4257.
23. Dynan, W. S., and R. Tjian. 1983. The promoter-specific transcription factor Sp1 hinds to upstream sequences in the SV40 early promoter. Cell 35:79-87.
24. Fondell, J. D., A. L. Roy, and R. G. Roeder. 1993. Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression. Genes Dev. 7:1400-1410.
25. Garcia-Bustos, J., J. Heitman, and M. N. Hall. 1991. Nuclear protein localization. Biochim. Biophys. Acta 1071:83-101.
26. Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
27. Graves, B. J., P. F. Johnson, and S. L. McKnight. 1986. Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene. Cell 44:565-576.
28. Han, K., and J. L. Manley. 1993. Functional domains of the Drosophila Engrailed protein. EMBO J. 12:2723-2733.
29. Han, K., and J. L. Manley. 1993. Transcriptional repression by the Drosophila even-skipped protein: definition of a minimal repression domain. Genes Dev. 7:491-503.
30. Harada, R., G. Berube, O. J. Tamplin, C. Denis-Larose, and A. Nepveu. 1995. DNA-binding specificity of the cut repeats from the human cut-like protein. Mol. Cell. Biol. 15:129-140.
31. Harada, R., D. Dufort, C. Denis-Larose, and A. Nepveu. 1994. Conserved cut repeats in the human cut homeodomain protein function as DNA binding domains. J. Biol. Chem. 269:2062-2067.
32. Herbomel, P., B. Bourachot, and M. Yaniv. 1984. Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma. Cell 39:653-662.
33. Inouye, C. J., and E. Seto. 1994. Relief of YY1-induced transcriptional repression by protein-protein interaction with the nucleolar phosphoprotein B23. J. Biol. Chem. 269:6506-6510.
34. Jack, J., D. Dorsett, Y. Delotto, and S. Liu. 1991. Expression of the Cut locus in the Drosophila wing margin is required for cell type specification and is regulated by a distant enhancer. Development 113:735-747.
35. Jaynes, J. B., and P. H. O'Farrell. 1991. Active repression of transcription by the engrailed homeodomain protein. EMBO J. 10:1427-1433.
36. Johnson, A. D., and I. Herskowitz. 1985. A repressor (MAT alpha 2 product) and its operator control expression of a set of cell type specific genes in yeast. Cell 42:237-247.
37. Jones, K. A., K. R. Yamamoto, and R. Tjian. 1985. Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro. Cell 42:559-572.
38. Kadonaga, J. T., K. R. Carner, F. R. Masiarz, and R. Tjian. 1987. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 51:1079-1090.
39. Kato, G. J., J. Barrett, M. Villa-Garcia, and C. V. Dang. 1990. An amino-terminal c-myc domain required for neoplastic transformation activates transcription. Mol. Cell. Biol. 10:5914-5920.
40. Kozak, M. 1986. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44:283-292.
41. Lee, K. A., A. Bindereif, and M. R. Green. 1988. A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing. Gene Anal. Tech. 5:22-31.
42. Licht, J. D., M. J. Grossel, J. Figge, and U. M. Hansen. 1990. Drosophila Kruppel protein is a transcriptional repressor. Nature (London) 346:76-79.
43. Licht, J. D., W. Hanna-Rose, J. C. Reddy, M. A. English, M. Ro, M. Grossel, and U. Hansen. 1994. Mapping and mutagenesis of the amino-terminal transcriptional repression domain of the Drosophila Kruppel protein. Mol. Cell. Biol. 14:4057-4066.
44. Lievens, P. M. J., J. J. Donady, C. Tufarelli, and E. J. Neufeld. 1995. Repressor activity of CCAAT displacement protein in HL-60 myeloid leukemia cells. J. Biol. Chem. 270:12745-12750.
45. Lillie, J. W., and M. R. Green. 1989. Transcription activation by the adenovirus E1a protein. Nature (London) 338:39-44.
46. Liu, S., and J. Jack. 1992. Regulatory interactions and role in cell type specification of the Malpighian tubules by the Cut, Kruppel, and caudal genes of Drosophila. Dev. Biol. 150:133-143.
47. Liu, S., E. McLeod, and J. Jack. 1991. Four distinct regulatory regions of the Cut locus and their effect on cell type specification in Drosophila. Genetics 127:151-159.
48. Luckow, B., and G. Schutz. 1987. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res. 15:5490-5490.
49. Madden, S. L., D. M. Cook, J. F. Morris, A. Gashler, V. P. Sukhatme, and I. F. Rauscher. 1991. Transcriptional repression mediated by the WT1 Wilms tumor gene product. Science 253:1550-1553.
50. Madden, S. L., D. M. Cook, and F. J. Rauscher. 1993. A structure-function analysis of transcriptional repression mediated by the WT1, Wilms' tumor suppressor protein. Oncogene 8:1713-1720.
51. Martin, K. J., J. W. Lillie, and M. R. Green. 1990. Evidence for interaction of different eukaryotic transcriptional activators with distinct cellular targets. Nature (London) 346:147-152.
52. Mastrangelo, I. A., A. J. Courey, J. S. Wall, S. P. Jackson, and P. V. Hough. 1991. DNA looping and Sp1 multimer links: a mechanism for transcriptional synergism and enhancement. Proc. Natl. Acad. Sci. USA 88:5670-5674.
53. McCutchan, J. H., and J. S. Pagano. 1968. Enchancement of the infectivity of simian virus 40 deoxyribonucleic acid with diethylaminoethyl-dextran. J. Natl. Cancer Inst. 41:351-357.
54. McKnight, S. L. 1992. CCAAT/enhancer binding proteins, p. 771-796. In S. L. McKnight and K. R. Yamamoto (ed.), Transcriptional regulation, vol. 2. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
55. Metz, R., A. J. Bannister, J. A. Sutherland, C. Hagemeier, E. C. O'Rourke, A. Cook, R. Bravo, and T. Kouzarides. 1994. c-Fos-induced activation of a TATA-box-containing promoter involves direct contact with TATA-box-binding protein. Mol. Cell. Biol. 14:6021-6029.
56. Neufeld, E. J., D. G. Skalnik, P. M. Lievens, and S. H. Orkin. 1992. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. Nat. Genet. 1:50-55.
57. Phillips, S., and A. Nepveu. Unpublished data.
58. Rauscher, F. J., III. 1993. Tumor suppressor genes which encode transcriptional repressors: studies on the EGR and Wilms' tumor (WT1) gene products. Adv. Exp. Med. Biol. 348:23-29.
59. Sadowski, I., and M. Ptashne. 1989. A vector for expressing GAL4(1-147) fusions in mammalian cells. Nucleic Acids Res. 17:7539-7539.
60. Saha, S., J. M. Brickman, N. Lehming, and M. Ptashne. 1993. New eukaryotic transcriptional repressors. Nature (London) 363:648-652.
61. Sauer, F., J. D. Fondell, Y. Ohkuma, R. G. Roeder, and H. Jackle. 1995. Control of transcription by Kruppel through interactions with TFIIB and TFIIE beta. Nature (London) 375:162-164.
62. Shi, Y., E. Seto, L. S. Chang, and T. Shenk. 1991. Transcriptional repression by YY1, a human GLI-Kruppel-relaled protein, and relief of repression by adenovirus E1A protein. Cell 67:377-388.
63. Skalnik, D. G., E. C. Strauss, and S. H. Orkin. 1991. CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter. J. Biol. Chem. 266:16736-16744.
64. Su, W., S. Jackson, R. Tjian, and H. Echols. 1991. DNA looping between sites for transcriptional activation: self-association of DNA-bound Sp1. Genes Dev. 5:820-826.
65. TenHarmsel, A., R. J. Austin, N. Savenelli, and M. D. Biggin. 1993. Cooperative binding at a distance by even-skipped protein correlates with repression and suggests a mechanism of silencing. Mol. Cell. Biol. 13:2742-2752.
66. Um, M., C. Li, and J. L. Manley. 1995. The transcriptional repressor Even-skipped interacts directly with the TATA-binding protein. Mol. Cell. Biol. 15:5007-5016.
67. Valarche, I., J. P. Tissier-Seta, M. R. Hirsch, S. Martinez, C. Goridis, and Brunet Jf. 1993. The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype. Development 119:881-896.
68. Wigler, M., A. Pellicer, S. Silverstein, R. Axel, G. Urlaub, and L. Chasin. 1979. DNA-mediated transfer of the adenine phospho-ribosyltransferase locus into mammalian cells. Proc. Natl. Acad. Sci. USA 76:1373-1376.
69. Yeung, K. C., J. A. Inostroza, F. H. Mermelstein, C. Kannabiran, and D. Reinberg. 1994. Structure-function analysis of the TBP-binding protein Dr1 reveals a mechanism for repression of class II gene transcription. Genes Dev. 8:2097-2109.
70. Yoon, S. O., and D. M. Chikaraishi. 1994. Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer. J. Biol. Chem. 269:18453-18462.
71. Zuo, P., D. Stanojevic, J. Colgan, K. Han, M. Levine, and J. L. Manley. 1991. Activation and repression of transcription by the gap proteins hunchback and Kruppel in cultured Drosophila cells. Genes Dev. 5:254-264.