Mitochondrial Mg2+ homeostasis is critical for group II intron splicing in vivo

Genes and Development

Volumn 15, Issue 17, 2001, Pages 2229-2237

  Gregan, Juraj ^a,b   Kolisek, Martin ^a   Schweyen, Rudolf J ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Group II introns; Mg2+; Mitochondria; Mrs2p; RNA splicing; Yeast

Indexed keywords

ARTICLE; INTRON; MAGNESIUM METABOLISM; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RNA SPLICING; SACCHAROMYCES CEREVISIAE;

ALLELES; DOSE-RESPONSE RELATIONSHIP, DRUG; EXONS; GENETIC VECTORS; GENOTYPE; INTRONS; MAGNESIUM; MITOCHONDRIA; MODELS, GENETIC; MUTATION; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA SPLICING; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SENSITIVITY AND SPECIFICITY; SUPPRESSION, GENETIC; TIME FACTORS;

BACTERIA (MICROORGANISMS); CORA; SACCHAROMYCES CEREVISIAE;

EID: 0035449356     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.201301     Document Type: Article

References (36)

1. The ins and outs of group II introns
2. 2+ transporter CorA can functionally substitute for its putative homologue Mrs2p in the yeast inner mitochondrial membrane
3. An mRNA maturase is encoded by the first intron of the mitochondrial gene for the subunit I of cytochrome oxidase in S. cerevisiae
4. Highly diverged homologs of Saccharomyces cerevisiae mitochondrial mRNA-specific translational activators have orthologous functions in other budding yeasts
5. Retrohoming: cDNA-mediated mobility of group II introns requires catalytic RNA
6. Introns gain ground
7. 2+ dependent control of its synthesis and degradation
8. 2+ homeostasis and group II intron splicing in yeast
9. Nucleo-mitochondrial interactions in mitochondrial gene expression
10. Long range control circuits within mitochondria and between nucleus and mitochondria. II: Genetic and biochemical analysis of suppressors which selectively alleviate the mitochondrial intron mutations
11. Trans-activation of group II intron splicing by nuclear U5 snRNA
12. Mrs5p, an essential protein of the mitochondrial intermembrane space, affects protein import into yeast mitochondria
13. Recruitment of petidyl-tRNA hydrolase as a facilitator of group II intron splicing in chloroplasts
14. Reverse transcriptase activity associated with maturase-encoding group II introns in yeast mitochondria
15. Tim10p and Tim12p, essential proteins of the mitochondrial intermembrane space involved in import of multispanning carrier proteins into the inner membrane
16. Three nuclear genes suppress a yeast mitochondrial splice defect when present in high copy number
17. Structure and activities of group II introns
18. Overexpression of DEAD box protein pMSS116 promotes ATP-dependent splicing of a yeast group II intron in vitro
19. A factor related to pseudouridine synthase is required for chloroplast group II intron trans-splicing in Chlamydomonas reinhardtii
20. A23187: A divalent cation ionophore
21. 2+ in rat heart mitochondria
22. Kar1, a gene required for function of both intranuclear and extranuclear microtubules in yeast
23. Group I and group II introns
24. Self-splicing of group II introns in vitro: Mapping of the branch point and mutational inhibition of lariat formation
25. Mutations of the two nucleotide bulge of D5 of a group II intron block splicing in vitro and in vivo: Phenotypes and suppressor mutations
26. Mutant alleles of the MRS2 gene of yeast nuclear DNA suppress mutations in the catalytic core of a mitochondrial group II intron
27. 2+ ion transporters complements a yeast mitochondrial group II intron splicing mutant
28. Mitochondrial splicing requires a protein from a novel helicase family
29. Metal ion catalysis during group II intron self-splicing: Parallels with the spliceosome
30. 1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins
31. Overexpression of a novel member of the mitochondrial carrier family rescues defects in both DNA and RNA metabolism in yeast mitochondria
32. A multitude of suppressors of group II intron-splicing defects in yeast
33. A reverse transcriptase/maturase promotes splicing by binding at its own coding segment in a group II intron RNA
34. MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family
35. The nuclear gene MRS2 is essential for the excision of group II introns from yeast mitochondrial transcripts in vivo
36. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue; a candidate magenesium transporter