Subnuclear localization and mitotic phosphorylation of HIRA, the human homologue of Saccharomyces cerevisiae transcriptional regulators Hir1p/Hir2p

Biochemical Journal

Volumn 358, Issue 2, 2001, Pages 447-455

  De Lucia, F ^a   Lorain, S ^a   Scamps, C ^a   Galisson, F ^a   Machold, J ^a   Lipinski, M ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Histone binding protein; Nuclear matrix; Protein half life

Indexed keywords

EXTRACTION; GENES; MICROSCOPIC EXAMINATION; YEAST;

MITOTIC PHOSPHORYLATION;

BIOCHEMISTRY;

PROTEIN; PROTEIN HIR1P; PROTEIN HIR2P; PROTEIN HIRA; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS MATRIX; CELL STRAIN K 562; CELLULAR DISTRIBUTION; CHROMATIN; CHROMOSOME CONDENSATION; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; MITOSIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

AMINO ACID MOTIFS; CELL CYCLE PROTEINS; CELL EXTRACTS; CHROMOSOMES; EVOLUTION, MOLECULAR; FLUORESCENT ANTIBODY TECHNIQUE; HALF-LIFE; HELA CELLS; HUMANS; K562 CELLS; MITOSIS; NUCLEAR MATRIX; NUCLEAR PROTEINS; PHOSPHORYLATION; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

EID: 0035448271     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3580447     Document Type: Article

References (51)

1. A human homolog of the S. cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical region
2. The HIR protein family: Isolation and characterization of a complete murine cDNA
3. Cloning and developmental expression analysis of chick Hira (Chira), a candidate gene for DiGeorge syndrome
4. Isolation and characterization of a new gene encoding a member of the HIRA family of proteins from Drosophila melanogaster
5. Isolation and genomic characterization of the TUPLE1/HIRA gene of the pufferfish Fugu rubripes
6. The WD repeat: A common architecture for diverse functions
7. A groovy new structure
8. Hira, a gene from the DGS/VCFS region, is required for normal embryogenesis
9. The DiGeorge syndrome minimal critical region contains a Goosecoid-like (GSCL) homeobox gene that is expressed early in human development
10. Molecular definition of 22q11 deletions in 151 velo-cardio-facial syndrome patients
11. The DiGeorge anomaly as a developmental field defect
12. Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice
13. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome
14. The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients
15. HIRA, a DiGeorge syndrome candidate gene, is required for cardiac outflow tract septation
16. Trans-acting regulatory mutations that alter transcription of Saccharomyces cerevisiae histone genes
17. Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae
18. Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle
19. A role for transcriptional repressors in targeting the yeast Swi/Snf complex
20. Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex
21. Facilitated binding of TATA-binding protein to nucleosomal DNA
22. Chromatin remodeling and the control of gene expression
23. Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection
24. Core histories and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA
25. HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3
26. HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin/cdk2 substrate whose expression blocks S-phase progression
27. AT-hook motifs identified in a wide variety of DNA-binding proteins
28. Nuclear protein matrix: Association with newly synthesized DNA
29. Modification of nuclear matrix proteins by ADP-ribosylation
30. The nuclear matrix: Three-dimensional architecture and protein composition
31. Identification of a nuclear protein matrix
32. Mitosis-specific phosphorylation of the nuclear oncoproteins Myc and Myb
33. The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis
34. Cell cycle regulation of the endogenous wild type Bloom's syndrome DNA helicase
35. The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development
36. Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains
37. The activity of brm/Snf2a is dependent on a high-mobility group protein I/Y-like DNA binding domain
38. Mapping the cell's nucleus
39. Mapping replication sites in eukaryotic cell nucleus
40. Intranuclear targeting of AML/CBFalpha regulatory factors to nuclear matrix-associated transcriptional domains
41. Three-dimensional visualization of transcription sites and their association with splicing factor-rich nuclear speckles
42. Rb and is involved in neuronal differentiation
43. PTIP, a novel BRCT domain-containing protein, interacts with Pax2 and is associated with active chromatin
44. Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix
45. Histone acetyl-transferase is associated with the nuclear matrix
46. Nuclear distribution of histone deacetylase: A marker enzyme for the internal nuclear matrix
47. Association of casein kinase-2 with nuclear matrix. Possible role in nuclear matrix protein phosphorylation
48. Cyclin/cdk2 complexes in the nucleus of HeLa cells
49. Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: Association with DNA replication sites