Effects of oral steroids on blood CXCR3+ and CCR4+ T cells in patients with bronchial asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 164, Issue 5, 2001, Pages 754-758

  Kurashima, Kazuyoshi ^a   Fujimura, Masaki ^b   Myou, Shigeharu ^b   Kasahara, Kazuo ^b   Tachibana, Hideki ^b   Amemiya, Norinao ^b   Ishiura, Yoshihisa ^b   Onai, Nobuyuki ^b   Matsushima, Kouji ^b   Nakao, Shinji ^b  

^a KANAZAWA UNIVERSITY   (Japan)

^b NONE

Author keywords

Asthma; Blood; Chemokine; Receptor; Steroid

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CXCR3; CORTICOSTEROID; IMMUNOGLOBULIN E; PREDNISOLONE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ALLERGIC ASTHMA; ARTICLE; ASTHMA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FORCED EXPIRATORY VOLUME; HELPER CELL; HUMAN; MALE; MEMORY CELL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SMOKING; T LYMPHOCYTE;

EID: 0035447570     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.164.5.2008132     Document Type: Article

References (37)

1. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma
2. Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity
3. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma
4. Activation of CD4+ T cells, increased Th2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma
5. The dendric cell system and its role in immunogenicity
6. The expanding universe of T-cell subsets: Th1, Th2 and more
7. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
8. Novel lymphocyte-specific CC chemokines and their receptors
9. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
10. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1) and Th2s
11. Differential expression of the chemokine receptors by the Th1- and Th2-type effector populations within circulating CD4+ T cells
12. Corticosteroids in the treatment of chronic asthma
13. Effect of an inhaled corticosteroid on airway inflammation and symptoms of asthma
14. Glucocorticoids affect functions of airway- and blood-derived human T-cell clones, favoring the Th1 profile through two mechanisms
15. Predonisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-γ cytokine gene expression
16. Standard for diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma
17. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine
18. Analysis of Th1 and Th2 cytokines expressing CD4+ and CD8+ T cells in rheumatoid arthritis by flow cytometry
19. T-cell cytokine pattern at three time points during specific immunotherapy for mite-sensitive asthma
20. The CC-chemokine receptor 5 (CCR5) is a marker of, but not essential for the development of human Th1 cells
21. Role of transcriptional activation of IκB alpha in mediation of immunosuppression by glucocorticoids
22. Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of I kappa B synthesis
23. Molecular mechanisms of steroid action in asthma
24. Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA
25. Glucocorticoids suppress the production of interleukin 4 by human lymphocytes
26. Inhibition of in vitro lymphokine synthesis by glucocorticoids
27. IL-12 transiently induces IFN-gamma transcription and protein synthesis in human CD4+ allergen-specific Th2 T cell clones
28. Induction of Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4
29. Glucocorticoids promote a Th2 cytokine response by CD4+ T cells in vitro
30. Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4
31. Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes
32. A new murine CD4+ T cell subset with an unristricted cytokine profile
33. The relationship of IL-4 and IFN-gamma-producing T cells studied by linage ablation of IL-4 producing cells
34. Human Tc1 and Tc2/Tc0 CD8 T-cell clones display cell surface and functional phenotypes
35. Dysregulation of interleukin 4, interleukin 5, and interferon γ gene expression in steroid-resistant asthma
36. Regulation by corticosteroids of Th1 and Th2 cytokine production in human CD4+ effector T cells generated from CD45RO- and CD45RO+ subsets