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Volumn 14, Issue 4, 1996, Pages 388-397

Glucocorticosteroids Affect Functions of Airway- and Blood-derived Human T-cell Clones, Favoring the Th1 Profile through Two Mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD3 ANTIGEN; CYTOKINE; DEXAMETHASONE; GAMMA INTERFERON; GLUCOCORTICOID; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 5;

EID: 0030117685     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.14.4.8600944     Document Type: Article
Times cited : (37)

References (58)
  • 2
    • 0026333085 scopus 로고
    • Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity
    • Walker, C., M. K. Kaegi, P. Braun, and K. Blaser. 1991. Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity. J. Allergy Clin. Immunol. 88:935-942.
    • (1991) J. Allergy Clin. Immunol. , vol.88 , pp. 935-942
    • Walker, C.1    Kaegi, M.K.2    Braun, P.3    Blaser, K.4
  • 4
    • 0029302202 scopus 로고
    • Phenotype of cells expressing mRNA for TH2-type (interleukin-4 and interleukin-5) and TH1-type (interleukin-2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects
    • Ying, S., S. R. Durham, C. J. Corrigan, Q. Hamid, and A. B. Kay. 1995. Phenotype of cells expressing mRNA for TH2-type (interleukin-4 and interleukin-5) and TH1-type (interleukin-2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects. Am. J. Respir. Cell Mol. Biol. 12:477-487.
    • (1995) Am. J. Respir. Cell Mol. Biol. , vol.12 , pp. 477-487
    • Ying, S.1    Durham, S.R.2    Corrigan, C.J.3    Hamid, Q.4    Kay, A.B.5
  • 5
    • 0026666718 scopus 로고
    • Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage
    • Walker, C., E. Bode, L. Boer, T. T. Hansel, K. Blaser, and J.-C. Virchow, Jr. 1992. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am. Rev. Respir. Dis. 146:109-115.
    • (1992) Am. Rev. Respir. Dis. , vol.146 , pp. 109-115
    • Walker, C.1    Bode, E.2    Boer, L.3    Hansel, T.T.4    Blaser, K.5    Virchow Jr., J.-C.6
  • 6
    • 0025374344 scopus 로고
    • Inflammatory cells and eosinophilic activity in asthmatics, investigated by bronchoalveolar lavage
    • Ädelroth, E., L. Rosenhall, S. Johansson, M. Linden, and P. Venge. 1990. Inflammatory cells and eosinophilic activity in asthmatics, investigated by bronchoalveolar lavage Am. Rev. Respir. Dis. 142:91-99.
    • (1990) Am. Rev. Respir. Dis. , vol.142 , pp. 91-99
    • Ädelroth, E.1    Rosenhall, L.2    Johansson, S.3    Linden, M.4    Venge, P.5
  • 7
    • 0026026861 scopus 로고
    • Respiratory membrane permeability and bronchial hyperreactivity in patients with stable asthma; effects of therapy with inhaled steroids
    • Van de Graaf, E. A., T. A. Out, C. M. Roos, and H. M. Jansen. 1991. Respiratory membrane permeability and bronchial hyperreactivity in patients with stable asthma; effects of therapy with inhaled steroids. Am. Rev. Respir. Dis. 143:362-368.
    • (1991) Am. Rev. Respir. Dis. , vol.143 , pp. 362-368
    • Van De Graaf, E.A.1    Out, T.A.2    Roos, C.M.3    Jansen, H.M.4
  • 9
    • 0026540867 scopus 로고
    • Lung function and immunopathological changes after inhaled corticosteroid therapy in asthma
    • Burke, C., C. K. Power, A. Norris, A. Condez, B. Schmekel, and L. W. Poulter. 1992. Lung function and immunopathological changes after inhaled corticosteroid therapy in asthma. Eur. Respir. J. 5:73-79.
    • (1992) Eur. Respir. J. , vol.5 , pp. 73-79
    • Burke, C.1    Power, C.K.2    Norris, A.3    Condez, A.4    Schmekel, B.5    Poulter, L.W.6
  • 10
    • 0027183057 scopus 로고
    • Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression
    • Robinson, D., Q. Hamid, S. Ying, A. Bentley, B. Assoufi, S. Durham, and A. B. Kay. 1993. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression. Am. Rev. Respir. Dis. 148:401-406.
    • (1993) Am. Rev. Respir. Dis. , vol.148 , pp. 401-406
    • Robinson, D.1    Hamid, Q.2    Ying, S.3    Bentley, A.4    Assoufi, B.5    Durham, S.6    Kay, A.B.7
  • 11
  • 12
    • 0018664625 scopus 로고
    • Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation
    • Gillis, S., G. R. Crabtree, and K. A. Smith. 1979. Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation. J. Immunol. 123:1624-1631.
    • (1979) J. Immunol. , vol.123 , pp. 1624-1631
    • Gillis, S.1    Crabtree, G.R.2    Smith, K.A.3
  • 13
    • 0021173449 scopus 로고
    • Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA
    • Arya, S. K., F. Wong-staal, and R. C. Gallo. 1984. Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA. J. Immunol. 133:273-276.
    • (1984) J. Immunol. , vol.133 , pp. 273-276
    • Arya, S.K.1    Wong-staal, F.2    Gallo, R.C.3
  • 14
    • 0026621211 scopus 로고
    • Inhibition of interleukin-5 gene expression by dexamethasone
    • Rolfe, F. G., J. M. Hughes, C. L. Armour, and W. A. Sewell. 1992. Inhibition of interleukin-5 gene expression by dexamethasone. Immunology 77:494-499.
    • (1992) Immunology , vol.77 , pp. 494-499
    • Rolfe, F.G.1    Hughes, J.M.2    Armour, C.L.3    Sewell, W.A.4
  • 15
    • 0025944559 scopus 로고
    • Glucocorticoids suppress the production of interleukin 4 by human lymphocytes
    • Wu, C. Y., C. Fargeas, T. Nakajima, and G. Delespesse. 1991. Glucocorticoids suppress the production of interleukin 4 by human lymphocytes. Eur. J. Immunol. 21:2645-2647.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 2645-2647
    • Wu, C.Y.1    Fargeas, C.2    Nakajima, T.3    Delespesse, G.4
  • 16
    • 0024802919 scopus 로고
    • Contrasting effects of glucocorticosteroids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4
    • Daynes, R. A., and B. A. Araneo. 1989. Contrasting effects of glucocorticosteroids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4. Eur. J. Immunol. 19:2319-2325.
    • (1989) Eur. J. Immunol. , vol.19 , pp. 2319-2325
    • Daynes, R.A.1    Araneo, B.A.2
  • 17
    • 0028941815 scopus 로고
    • Corticosteroids class-dependently inhibit in vitro Th1 and Th2-type cytokine production
    • Snijdewint, F. G. M., M. L. Kapsenberg, P. J. J. Wauben-Penris, and J. Bos. 1995. Corticosteroids class-dependently inhibit in vitro Th1 and Th2-type cytokine production. Immunopharmacology 29:93-101.
    • (1995) Immunopharmacology , vol.29 , pp. 93-101
    • Snijdewint, F.G.M.1    Kapsenberg, M.L.2    Wauben-Penris, P.J.J.3    Bos, J.4
  • 18
    • 0021967967 scopus 로고
    • Differentiation and activation phenotypes of lung T-lymphocytes differ from those of circulating T-lymphocytes
    • Davidson, B. L., J. Faust, S. Pessano, R. P. Daniele, and G. Rovera. 1985. Differentiation and activation phenotypes of lung T-lymphocytes differ from those of circulating T-lymphocytes. J. Clin. Invest. 76:60-65.
    • (1985) J. Clin. Invest. , vol.76 , pp. 60-65
    • Davidson, B.L.1    Faust, J.2    Pessano, S.3    Daniele, R.P.4    Rovera, G.5
  • 19
    • 0025343299 scopus 로고
    • Biased accumulation of T-lymphocytes with "memory"-type CD45 leucocyte common antigen expression on the epithelial surface of the human lung
    • Saltini, C., M. Kirby, B. C. Trapnell, N. Tamura, and R. G. Crystal. 1990. Biased accumulation of T-lymphocytes with "memory"-type CD45 leucocyte common antigen expression on the epithelial surface of the human lung. J. Exp. Med. 171:1123-1140.
    • (1990) J. Exp. Med. , vol.171 , pp. 1123-1140
    • Saltini, C.1    Kirby, M.2    Trapnell, B.C.3    Tamura, N.4    Crystal, R.G.5
  • 23
    • 1842524780 scopus 로고
    • Cytokine production by T-cell clones from bronchoalveolar lavage fluid of patients with asthma and healthy controls
    • In press
    • Krouwels, F. H., B. E. A. Hol, B. Bruinier, R. Lutter, H. M. Jansen, and T. A. Out. 1995. Cytokine production by T-cell clones from bronchoalveolar lavage fluid of patients with asthma and healthy controls. Eur. Respir. J. (In press)
    • (1995) Eur. Respir. J.
    • Krouwels, F.H.1    Hol, B.E.A.2    Bruinier, B.3    Lutter, R.4    Jansen, H.M.5    Out, T.A.6
  • 24
    • 0020606965 scopus 로고
    • Blockade of the interleukin-2 receptor by anti-Tac antibody: Inhibition of human lymphocyte activation
    • Depper, J. M., W. J. Leonard, R. J. Robb, T. A. Waldmann, and W. C. Greene. 1983. Blockade of the interleukin-2 receptor by anti-Tac antibody: inhibition of human lymphocyte activation. J. Immunol. 131:690-696.
    • (1983) J. Immunol. , vol.131 , pp. 690-696
    • Depper, J.M.1    Leonard, W.J.2    Robb, R.J.3    Waldmann, T.A.4    Greene, W.C.5
  • 26
    • 0020594115 scopus 로고
    • Production and characterization of monoclonal antibodies to human interleukin 2: Strategy and tactics
    • Smith, K. A., M. F. Favata, and S. Oroszlan. 1983. Production and characterization of monoclonal antibodies to human interleukin 2: strategy and tactics. J. Immunol. 131:1808-1816.
    • (1983) J. Immunol. , vol.131 , pp. 1808-1816
    • Smith, K.A.1    Favata, M.F.2    Oroszlan, S.3
  • 28
    • 0027963243 scopus 로고
    • Peptide specificity and HLA restriction do not dictate lymphokine production by allergen-specific T-lymphocyte clones
    • Van Neerven, R. J. J., M. M. Van de Pol, E. A. Wierenga, R. C. Aalberse, H. M. Jansen, and M. L. Kapsenberg. 1994. Peptide specificity and HLA restriction do not dictate lymphokine production by allergen-specific T-lymphocyte clones. Immunology 82:351-356.
    • (1994) Immunology , vol.82 , pp. 351-356
    • Van Neerven, R.J.J.1    Van De Pol, M.M.2    Wierenga, E.A.3    Aalberse, R.C.4    Jansen, H.M.5    Kapsenberg, M.L.6
  • 30
    • 0021848452 scopus 로고
    • Monoclonal antibodies to human immune interferon and their use in a sensitive solid-phase ELISA
    • Van der Meide, P. H., M. Dubbeld, and H. Schellekens. 1985. Monoclonal antibodies to human immune interferon and their use in a sensitive solid-phase ELISA. J. Immunol. Methods 79:293-305.
    • (1985) J. Immunol. Methods , vol.79 , pp. 293-305
    • Van Der Meide, P.H.1    Dubbeld, M.2    Schellekens, H.3
  • 31
    • 0025856722 scopus 로고
    • Production, characterisation and use of monoclonal antibodies to human interleukin-5 in an enzyme-linked immunoabsorbent assay
    • McNamee, L. A., D. I. Fattah, T. J. Baker, S. K. Bains, and P. H. Hissey. 1991. Production, characterisation and use of monoclonal antibodies to human interleukin-5 in an enzyme-linked immunoabsorbent assay. J. Immunol. Methods 141:81-88.
    • (1991) J. Immunol. Methods , vol.141 , pp. 81-88
    • McNamee, L.A.1    Fattah, D.I.2    Baker, T.J.3    Bains, S.K.4    Hissey, P.H.5
  • 32
    • 0026737267 scopus 로고
    • Flow cytometric assay for quantifying opsonophagocytosis and killing of Staphylococcus aureus by peripheral blood leukocytes
    • Martin, E., and S. Bhakdi. 1992. Flow cytometric assay for quantifying opsonophagocytosis and killing of Staphylococcus aureus by peripheral blood leukocytes. J. Clin. Microbiol. 30:2246-2255.
    • (1992) J. Clin. Microbiol. , vol.30 , pp. 2246-2255
    • Martin, E.1    Bhakdi, S.2
  • 34
    • 0025778240 scopus 로고
    • The interleukin-2 receptor
    • Waldmann, T. A. 1991. The interleukin-2 receptor. J. Biol. Chem. 266: 2681-2684.
    • (1991) J. Biol. Chem. , vol.266 , pp. 2681-2684
    • Waldmann, T.A.1
  • 35
    • 0026521321 scopus 로고
    • An associated molecule, p64, with IL-2 receptor β-chain: Its possible involvement in the formation of the functional intermediate-affinity IL-2 receptor complex
    • Takeshita, T., K. Ohtani, H. Asao, S. Kumaki, M. Nakamura, and K. Sugamura. 1992. An associated molecule, p64, with IL-2 receptor β-chain: its possible involvement in the formation of the functional intermediate-affinity IL-2 receptor complex. J. Immunol. 148:2154-2162.
    • (1992) J. Immunol. , vol.148 , pp. 2154-2162
    • Takeshita, T.1    Ohtani, K.2    Asao, H.3    Kumaki, S.4    Nakamura, M.5    Sugamura, K.6
  • 38
    • 0025935046 scopus 로고
    • Glucocorticoid resistance in chronic asthma. Glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro
    • Corrigan, C. J., P. H. Brown, N. C. Barnes, S. J. Szefler, J.-J. Tsai, A. J. Frew, and A. B. Kay. 1991. Glucocorticoid resistance in chronic asthma. Glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro. Am. Rev. Respir. Dis. 144:1016-1025.
    • (1991) Am. Rev. Respir. Dis. , vol.144 , pp. 1016-1025
    • Corrigan, C.J.1    Brown, P.H.2    Barnes, N.C.3    Szefler, S.J.4    Tsai, J.-J.5    Frew, A.J.6    Kay, A.B.7
  • 40
    • 0028033431 scopus 로고
    • The effect of different corticosteroids and cyclosporin a on interleukin-4 and interleukin-5 release from murine TH2-type T cells
    • Schmidt, J., S. Fleissner, I. Heimann-Weitschat, R. Lindstaedt, and I. Szelenyi. 1994. The effect of different corticosteroids and cyclosporin A on interleukin-4 and interleukin-5 release from murine TH2-type T cells. Eur. J. Pharmacol. 260:247-250.
    • (1994) Eur. J. Pharmacol. , vol.260 , pp. 247-250
    • Schmidt, J.1    Fleissner, S.2    Heimann-Weitschat, I.3    Lindstaedt, R.4    Szelenyi, I.5
  • 42
    • 0028879819 scopus 로고
    • Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids
    • Scheinman, R. I., P. C. Cogswell, A. K. Lofquist and A. S. Baldwin. 1995. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270:283-286.
    • (1995) Science , vol.270 , pp. 283-286
    • Scheinman, R.I.1    Cogswell, P.C.2    Lofquist, A.K.3    Baldwin, A.S.4
  • 43
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis
    • Auphan, N., J. A. Didonato, C. Rosette, A. Helmberg, and M. Karin. 1995. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 270:286-290.
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1    Didonato, J.A.2    Rosette, C.3    Helmberg, A.4    Karin, M.5
  • 44
    • 0025222698 scopus 로고
    • IL-4 directs the development of Th2-like helper effectors
    • Swain, S. L., A. D. Weinberg, M. English, and G. Huston. 1990. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145: 3796-3806.
    • (1990) J. Immunol. , vol.145 , pp. 3796-3806
    • Swain, S.L.1    Weinberg, A.D.2    English, M.3    Huston, G.4
  • 45
    • 0026262060 scopus 로고
    • Regulation of transforming growth factor-beta 1 gene expression by glucocorticoids in normal human T lymphocytes
    • Batuman, O. A., A. P. Ferrero, A. Diaz, and S. A. Jimenez. 1991. Regulation of transforming growth factor-beta 1 gene expression by glucocorticoids in normal human T lymphocytes. J. Clin. Invest. 88:1574-1580.
    • (1991) J. Clin. Invest. , vol.88 , pp. 1574-1580
    • Batuman, O.A.1    Ferrero, A.P.2    Diaz, A.3    Jimenez, S.A.4
  • 46
    • 0028897431 scopus 로고
    • Nitric oxide and asthmatic inflammation
    • Barnes, P. J., and F. Y. Liew. 1995. Nitric oxide and asthmatic inflammation. Immunol. Today 16:128-130.
    • (1995) Immunol. Today , vol.16 , pp. 128-130
    • Barnes, P.J.1    Liew, F.Y.2
  • 47
    • 0025221099 scopus 로고
    • Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages
    • Di Rosa, M., M. Radomski, R. Carnuccio, and S. Moncada. 1990. Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem. Biophys. Res. Commun. 172:1246-1252.
    • (1990) Biochem. Biophys. Res. Commun. , vol.172 , pp. 1246-1252
    • Di Rosa, M.1    Radomski, M.2    Carnuccio, R.3    Moncada, S.4
  • 48
    • 0022590679 scopus 로고
    • Effect of cyclosporin a and dexamethasone on interleukin 2 receptor gene regulation
    • Reed, J. C. 1986. Effect of cyclosporin A and dexamethasone on interleukin 2 receptor gene regulation. J. Immunol. 137:150-154.
    • (1986) J. Immunol. , vol.137 , pp. 150-154
    • Reed, J.C.1
  • 50
    • 0028048358 scopus 로고
    • Abrogation of the suppressive effects of dexamethasone by PKC activation or CD28 triggering
    • Nijhuis, E. W. P., B. Hinloopen, J. Odding, and L. Nagelkerken. 1994. Abrogation of the suppressive effects of dexamethasone by PKC activation or CD28 triggering. Cell. Immunol. 156:438-447.
    • (1994) Cell. Immunol. , vol.156 , pp. 438-447
    • Nijhuis, E.W.P.1    Hinloopen, B.2    Odding, J.3    Nagelkerken, L.4
  • 51
    • 0028107237 scopus 로고
    • Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappaB and the glucocorticoid receptor
    • Ray, A., and K. E. Prefontaine. 1994. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappaB and the glucocorticoid receptor. Prof. Natl. Acad. Sci. USA 91:752-756.
    • (1994) Prof. Natl. Acad. Sci. USA , vol.91 , pp. 752-756
    • Ray, A.1    Prefontaine, K.E.2
  • 52
    • 0024842122 scopus 로고
    • IL-2 protects T cell hybrids from the cytolytic effect of glucocorticoids. Synergistic effect of IL-2 and dexamethasone in the induction of high-affinity IL-2 receptors
    • Fernández-Ruiz, E., A. Rebollo, M. A. Nieto, E. Sanz, C. Somoza, F. Ramirez, A. Lopez-Rivas, and A. Silva. 1989. IL-2 protects T cell hybrids from the cytolytic effect of glucocorticoids. Synergistic effect of IL-2 and dexamethasone in the induction of high-affinity IL-2 receptors. J. Immunol. 143:4146-4151.
    • (1989) J. Immunol. , vol.143 , pp. 4146-4151
    • Fernández-Ruiz, E.1    Rebollo, A.2    Nieto, M.A.3    Sanz, E.4    Somoza, C.5    Ramirez, F.6    Lopez-Rivas, A.7    Silva, A.8
  • 54
    • 0028277327 scopus 로고
    • Control of T lymphocyte activation and IL-2 receptor expression by endogenously secreted lymphokines
    • Pimentel-Muiños, F. X., M. A. Muñoz-Fernández, and M. Fresno. 1994. Control of T lymphocyte activation and IL-2 receptor expression by endogenously secreted lymphokines. J. Immunol. 152:5714-5722.
    • (1994) J. Immunol. , vol.152 , pp. 5714-5722
    • Pimentel-Muiños, F.X.1    Muñoz-Fernández, M.A.2    Fresno, M.3
  • 55
    • 0025832496 scopus 로고
    • Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription
    • Boumpas, D. T., E. D. Anastassiou, S. A. Older, G. C. Tsokos, D. L. Nelson, and J. E. Balow. 1991. Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription. J. Clin. Invest. 87:1739-1747.
    • (1991) J. Clin. Invest. , vol.87 , pp. 1739-1747
    • Boumpas, D.T.1    Anastassiou, E.D.2    Older, S.A.3    Tsokos, G.C.4    Nelson, D.L.5    Balow, J.E.6
  • 56
    • 0027440434 scopus 로고
    • Novel mechanism for inhibition of human T cells by glucocorticoids: Glucocorticoids inhibit signal transduction through IL-2 receptor
    • Paliogianni, F., S. S. Ahuja, J. P. Balow, J. E. Balow, and D. T. Boumpas. 1993. Novel mechanism for inhibition of human T cells by glucocorticoids: glucocorticoids inhibit signal transduction through IL-2 receptor. J. Immunol. 151:4081-4089.
    • (1993) J. Immunol. , vol.151 , pp. 4081-4089
    • Paliogianni, F.1    Ahuja, S.S.2    Balow, J.P.3    Balow, J.E.4    Boumpas, D.T.5
  • 57
    • 0026005520 scopus 로고
    • Glucocorticoid resistance in chronic asthma. Peripheral blood T lymphocyte activation and comparison of the T lymphocyte inhibitory effects of glucocorticoids and cyclosporin A
    • Corrigan, C. J., P. H. Brown, N. C. Barnes, J.-J. Tsai, A. J. Frew, and A. B. Kay. 1991. Glucocorticoid resistance in chronic asthma. Peripheral blood T lymphocyte activation and comparison of the T lymphocyte inhibitory effects of glucocorticoids and cyclosporin A. Am. Rev. Respir. Dis. 144:1026-1032.
    • (1991) Am. Rev. Respir. Dis. , vol.144 , pp. 1026-1032
    • Corrigan, C.J.1    Brown, P.H.2    Barnes, N.C.3    Tsai, J.-J.4    Frew, A.J.5    Kay, A.B.6
  • 58
    • 0028944915 scopus 로고
    • Dysregulation of interleukin 4, interleukin 5, and interferon γ gene expression in steroid-resistant asthma
    • Leung, D. Y. M., R. J. Martin, S. J. Szefler, E. R. Sher, S. Ying, A. B. Kay, and Q. Hamid. 1995. Dysregulation of interleukin 4, interleukin 5, and interferon γ gene expression in steroid-resistant asthma. J. Exp. Med. 181:33-40.
    • (1995) J. Exp. Med. , vol.181 , pp. 33-40
    • Leung, D.Y.M.1    Martin, R.J.2    Szefler, S.J.3    Sher, E.R.4    Ying, S.5    Kay, A.B.6    Hamid, Q.7


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