1-[(Benzofuran-2-yl)phenylmethyl]triazoles as steroidogenic inhibitors: Synthesis and in vitro inhibition of human placental CYP19 aromatase

Anti-Cancer Drug Design

Volumn 16, Issue 4-5, 2001, Pages 217-225

  Vinh, T K ^a   Yee, S W ^a   Kirbyl, A J ^a   Nicholls, R J ^a   Simons, C ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

1 (Benzofuran 2 yl)phenylmethyl 1,2,4 triazoles; Breast cancer; IC50 P450 aromatase P450 17 (17,20 lyase)

Indexed keywords

1 [(BENZOFURAN 2 YL)PHENYLMETHYL] 1,2,4 TRIAZOLE; 1 [(BENZOFURAN 2 YL)PHENYLMETHYL]TRIAZOLE; AROMATASE; CYTOCHROME P450 17; CYTOCHROME P450 INHIBITOR; ESTRADIOL; ESTRONE; PHENYL GROUP; STEROID; TESTOSTERONE 17BETA DEHYDROGENASE; TESTOSTERONE 17BETA DEHYDROGENASE 1; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; HORMONE STRUCTURE; HORMONE SYNTHESIS; HUMAN; IC 50; PLACENTA; PRIORITY JOURNAL; SUBSTITUTION REACTION; TESTIS;

ADULT; ANIMALS; AROMATASE INHIBITORS; BENZOFURANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; ESTROGENS; FEMALE; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSOMES; PLACENTA; PREGNANCY; RATS; STEROID 17-ALPHA-HYDROXYLASE; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP; TESTIS; TRIAZOLES;

EID: 0035437393     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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