메뉴 건너뛰기




Volumn 50, Issue 8, 2001, Pages 1791-1798

Glycerol-Stimulated Proinsulin Biosynthesis in Isolated Pancreatic Rat Islets via Adenoviral-Induced Expression of Glycerol Kinase Is Mediated via Mitochondrial Metabolism

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CYANO 4 HYDROXYCINNAMIC ACID; ALPHA-CYANO-4-HYDROXYCINNAMATE; ALPHA-GLYCEROPHOSPHORIC ACID; BETA GALACTOSIDASE; COUMARIC ACID; CYSTEINE PROTEINASE INHIBITOR; DIHYDROXYACETONE PHOSPHATE; GLUCOSE; GLYCEROL KINASE; GLYCEROPHOSPHATE; LACTIC ACID DERIVATIVE; PROINSULIN; RECOMBINANT PROTEIN;

EID: 0035434658     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.8.1791     Document Type: Article
Times cited : (15)

References (38)
  • 1
    • 0018892185 scopus 로고
    • Glucoreceptor mechanisms and the control of insulin release and biosynthesis
    • Ashcroft SJH: Glucoreceptor mechanisms and the control of insulin release and biosynthesis. Diabetologia 18:5-15, 1980
    • (1980) Diabetologia , vol.18 , pp. 5-15
    • Ashcroft, S.J.H.1
  • 2
    • 0002087398 scopus 로고    scopus 로고
    • Processing of the insulin molecule
    • LeRoith D, Taylor SI, Olefsky JM, Eds. Philadelphia, PA, Lippincott-Raven Publishers
    • Rhodes CJ: Processing of the insulin molecule. In Processing of the Insulin Molecule. 2nd ed. LeRoith D, Taylor SI, Olefsky JM, Eds. Philadelphia, PA, Lippincott-Raven Publishers, 2000, p. 20-37
    • (2000) Processing of the Insulin Molecule. 2nd Ed. , pp. 20-37
    • Rhodes, C.J.1
  • 3
    • 0022254988 scopus 로고
    • The insulin factory: A tour of the plant surroundings and a visit to the assembly line
    • Orci L: The insulin factory: a tour of the plant surroundings and a visit to the assembly line. Diabetologia 28:528-546, 1985
    • (1985) Diabetologia , vol.28 , pp. 528-546
    • Orci, L.1
  • 4
    • 0029932643 scopus 로고    scopus 로고
    • New insights into pancreatic β-cell metabolic signaling in insulin secretion
    • Prentki M: New insights into pancreatic β-cell metabolic signaling in insulin secretion. Eur J Endocrinol 134:272-286, 1996
    • (1996) Eur J Endocrinol , vol.134 , pp. 272-286
    • Prentki, M.1
  • 5
    • 0029071517 scopus 로고
    • Metabolic coupling factors in pancreatic β-cell signal transduction
    • Newgard CB, McGarry JD: Metabolic coupling factors in pancreatic β-cell signal transduction. Annu Rev Biochem 64:689-719, 1995
    • (1995) Annu Rev Biochem , vol.64 , pp. 689-719
    • Newgard, C.B.1    McGarry, J.D.2
  • 6
    • 0002955624 scopus 로고
    • Mechanism of insulin secretion
    • Ashcroft FM, Achcroft SJH, Eds. Oxford, U.K., Oxford University Press
    • Ashcroft FM, Ashcroft SJH: Mechanism of insulin secretion. In Mechanism of Insulin Secretion. 1st ed. Ashcroft FM, Achcroft SJH, Eds. Oxford, U.K., Oxford University Press, 1992, p. 97-150
    • (1992) Mechanism of Insulin Secretion. 1st Ed. , pp. 97-150
    • Ashcroft, F.M.1    Ashcroft, S.J.H.2
  • 8
    • 0029097424 scopus 로고
    • Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion
    • MacDonald MJ: Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion. J Biol Chem 270:20051-20058, 1995
    • (1995) J Biol Chem , vol.270 , pp. 20051-20058
    • MacDonald, M.J.1
  • 9
    • 0031865596 scopus 로고    scopus 로고
    • Overexpression of mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase does not correct glucose-stimulated insulin secretion from diabetic GK rat pancreatic islets
    • Ueda K, Tanizawa Y, Ishihara H, Kizuki N, Ohta Y, Matsutani A, Oka Y: Overexpression of mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase does not correct glucose-stimulated insulin secretion from diabetic GK rat pancreatic islets. Diabetologia 41:649-653, 1998
    • (1998) Diabetologia , vol.41 , pp. 649-653
    • Ueda, K.1    Tanizawa, Y.2    Ishihara, H.3    Kizuki, N.4    Ohta, Y.5    Matsutani, A.6    Oka, Y.7
  • 10
    • 0034695641 scopus 로고    scopus 로고
    • The oscillatory behavior of pancreatic islets from mice with mitochondrial glycerol-3-phosphate dehydrogenase knockout
    • Ravier MA, Eto K, Jonkers FC, Nenquin M, Kadowaki T, Henquin JC: The oscillatory behavior of pancreatic islets from mice with mitochondrial glycerol-3-phosphate dehydrogenase knockout. J Biol Chem 275:1587-1593, 2000
    • (2000) J Biol Chem , vol.275 , pp. 1587-1593
    • Ravier, M.A.1    Eto, K.2    Jonkers, F.C.3    Nenquin, M.4    Kadowaki, T.5    Henquin, J.C.6
  • 11
    • 0030810982 scopus 로고    scopus 로고
    • Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells
    • Schuit F, De Vos A, Farfari S, Moens K, Pipeleers D, Brun T, Prentki M: Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells. J Biol Chem 272:18572-18579, 1997
    • (1997) J Biol Chem , vol.272 , pp. 18572-18579
    • Schuit, F.1    De Vos, A.2    Farfari, S.3    Moens, K.4    Pipeleers, D.5    Brun, T.6    Prentki, M.7
  • 12
    • 0032522368 scopus 로고    scopus 로고
    • A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties
    • Skelly RH, Bollheimer LC, Wicksteed BL, Corkey BE, Rhodes CJ: A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties. Biochem J 331:553-561, 1997
    • (1997) Biochem J , vol.331 , pp. 553-561
    • Skelly, R.H.1    Bollheimer, L.C.2    Wicksteed, B.L.3    Corkey, B.E.4    Rhodes, C.J.5
  • 13
    • 0034072556 scopus 로고    scopus 로고
    • Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: Possible implication of a pyruvate/citrate shuttle in insulin secretion
    • Farfari S, Schulz V, Corkey BE, Prentki M: Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion. Diabetes 49:718-726, 2000
    • (2000) Diabetes , vol.49 , pp. 718-726
    • Farfari, S.1    Schulz, V.2    Corkey, B.E.3    Prentki, M.4
  • 14
    • 0033936159 scopus 로고    scopus 로고
    • What couples glycolysis to mitochondrial signal generation in glucose-stimulated insulin secretion?
    • Ishihara H, Wollheim CB: What couples glycolysis to mitochondrial signal generation in glucose-stimulated insulin secretion? IUBMB Life 49:391-395, 2000
    • (2000) IUBMB Life , vol.49 , pp. 391-395
    • Ishihara, H.1    Wollheim, C.B.2
  • 15
    • 0018831212 scopus 로고
    • Translational control of proinsulin synthesis by glucose
    • Itoh N, Okamoto H: Translational control of proinsulin synthesis by glucose. Nature 283:100-102, 1980
    • (1980) Nature , vol.283 , pp. 100-102
    • Itoh, N.1    Okamoto, H.2
  • 16
    • 0022535308 scopus 로고
    • Translational control of insulin biosynthesis: Evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose
    • Welsh M, Scherberg N, Gilmore R, Steiner DF: Translational control of insulin biosynthesis: evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose. Biochem. J 235:459-467, 1986
    • (1986) Biochem. J , vol.235 , pp. 459-467
    • Welsh, M.1    Scherberg, N.2    Gilmore, R.3    Steiner, D.F.4
  • 17
    • 0024495665 scopus 로고
    • Regulation of the biosynthesis of insulin secretory granule proteins: Co-ordinate translational control is exerted on some but not all granule matrix constituents
    • Guest PG, Rhodes CJ, Hutton JC: Regulation of the biosynthesis of insulin secretory granule proteins: co-ordinate translational control is exerted on some but not all granule matrix constituents. Biochem J 257:431-437, 1989
    • (1989) Biochem J , vol.257 , pp. 431-437
    • Guest, P.G.1    Rhodes, C.J.2    Hutton, J.C.3
  • 18
    • 0030033858 scopus 로고    scopus 로고
    • Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line
    • Skelly RH, Schuppin GT, Ishihara H, Oka Y, Rhodes CJ: Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line. Diabetes 45:37-43, 1996
    • (1996) Diabetes , vol.45 , pp. 37-43
    • Skelly, R.H.1    Schuppin, G.T.2    Ishihara, H.3    Oka, Y.4    Rhodes, C.J.5
  • 19
    • 0032030866 scopus 로고    scopus 로고
    • Chronic exposure to free fatty acid reduces pancreatic β-cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation
    • Bollheimer LC, Skelly RH, Chester M, McGarry JD, Rhodes CJ: Chronic exposure to free fatty acid reduces pancreatic β-cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest 101:1094-1101, 1998
    • (1998) J Clin Invest , vol.101 , pp. 1094-1101
    • Bollheimer, L.C.1    Skelly, R.H.2    Chester, M.3    McGarry, J.D.4    Rhodes, C.J.5
  • 20
    • 0030753653 scopus 로고    scopus 로고
    • Engineering of glycerol-stimulated insulin secretion in islet β-cells: Differential fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling
    • Noel RJ, Antinozzi PA, McGarry JD, Newgard CB: Engineering of glycerol-stimulated insulin secretion in islet β-cells: differential fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling. J Biol Chem 272:18621-18627, 1997
    • (1997) J Biol Chem , vol.272 , pp. 18621-18627
    • Noel, R.J.1    Antinozzi, P.A.2    McGarry, J.D.3    Newgard, C.B.4
  • 21
    • 0027418977 scopus 로고
    • The biosynthesis of the subtilisin-related proprotein covertase PC3, but not that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets
    • Alarcón C, Lincoln B, Rhodes CJ: The biosynthesis of the subtilisin-related proprotein covertase PC3, but not that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets. J Biol Chem 268:4276-4280, 1993
    • (1993) J Biol Chem , vol.268 , pp. 4276-4280
    • Alarcón, C.1    Lincoln, B.2    Rhodes, C.J.3
  • 22
    • 0021709960 scopus 로고
    • Activities of glucokinase and hexokinase in mammalian and avian livers
    • Stanley JC, Dohm GL, McManus BS, Newsholme EA: Activities of glucokinase and hexokinase in mammalian and avian livers. Biochem J 224:667-671, 1984
    • (1984) Biochem J , vol.224 , pp. 667-671
    • Stanley, J.C.1    Dohm, G.L.2    McManus, B.S.3    Newsholme, E.A.4
  • 23
    • 0018337607 scopus 로고
    • Assay of citric acid cycle intermediates and related compounds. Update with tissue metabolite levels and intracellular distribution
    • Williamson JR, Corkey BE: Assay of citric acid cycle intermediates and related compounds. Update with tissue metabolite levels and intracellular distribution. Methods Enzymol 55:200-222, 1979
    • (1979) Methods Enzymol , vol.55 , pp. 200-222
    • Williamson, J.R.1    Corkey, B.E.2
  • 25
    • 0015318041 scopus 로고
    • Oxidation of glucose and fatty acids in normal and in A2-cell rich pancreatic islets isolated from guinea-pigs
    • Edwards JC, Hellerström C, Petersson B, Taylor KW: Oxidation of glucose and fatty acids in normal and in A2-cell rich pancreatic islets isolated from guinea-pigs. Diabetologia 8:93-98, 1972
    • (1972) Diabetologia , vol.8 , pp. 93-98
    • Edwards, J.C.1    Hellerström, C.2    Petersson, B.3    Taylor, K.W.4
  • 27
    • 0027994097 scopus 로고
    • Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels
    • Becker TC, Beltrandel Rio H, Noel RJ, Johnson JH, Newgard CB: Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels. J Biol Chem 269:21234-21238, 1994
    • (1994) J Biol Chem , vol.269 , pp. 21234-21238
    • Becker, T.C.1    Beltrandel Rio, H.2    Noel, R.J.3    Johnson, J.H.4    Newgard, C.B.5
  • 29
    • 0028334658 scopus 로고
    • Glucose-stimulated increase in cytoplasmic pH precedes increase in free Ca2+ in pancreatic β-cells. a possible role for pyruvate
    • Juntti-Berggren L, Civelek VN, Berggren PO, Schultz V, Corkey BE, Tornheim K: Glucose-stimulated increase in cytoplasmic pH precedes increase in free Ca2+ in pancreatic β-cells. A possible role for pyruvate. J Biol Chem 269:14391-14395, 1994
    • (1994) J Biol Chem , vol.269 , pp. 14391-14395
    • Juntti-Berggren, L.1    Civelek, V.N.2    Berggren, P.O.3    Schultz, V.4    Corkey, B.E.5    Tornheim, K.6
  • 30
    • 0021327174 scopus 로고
    • Subcellular origin of the fluorescence of reduced nicotinamide nucleotides in the isolated perfused rat heart
    • Nuutinen EM: Subcellular origin of the fluorescence of reduced nicotinamide nucleotides in the isolated perfused rat heart. Basic Res Cardiol 79:49-58, 1984
    • (1984) Basic Res Cardiol , vol.79 , pp. 49-58
    • Nuutinen, E.M.1
  • 31
    • 0025240754 scopus 로고
    • Glucose requirement for postischemic recovery of perfused working heart
    • Mallet RT, Hartman DA, Bunger R: Glucose requirement for postischemic recovery of perfused working heart. Eur J Biochem 188:481-493, 1990
    • (1990) Eur J Biochem , vol.188 , pp. 481-493
    • Mallet, R.T.1    Hartman, D.A.2    Bunger, R.3
  • 32
    • 0022971578 scopus 로고
    • Metabolic concomitants in pure, pancreatic beta cells during glucose-stimulated insulin secretion
    • Matchinsky FM, Ghosh AM, Meglasson MD, Prenki M, June V, von Allman D: Metabolic concomitants in pure, pancreatic beta cells during glucose-stimulated insulin secretion. J Biol Chem 261:14057-14061, 1986
    • (1986) J Biol Chem , vol.261 , pp. 14057-14061
    • Matchinsky, F.M.1    Ghosh, A.M.2    Meglasson, M.D.3    Prenki, M.4    June, V.5    Von Allman, D.6
  • 33
    • 0032568920 scopus 로고    scopus 로고
    • Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion: A reevalution of the long chain acyl-Coa hypothesis
    • Antinozzi PA, Segall L, Prentki M, McGarry JD, Newgard CB: Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion: a reevalution of the long chain acyl-CoA hypothesis. J Biol Chem 273:16146-16154, 1998
    • (1998) J Biol Chem , vol.273 , pp. 16146-16154
    • Antinozzi, P.A.1    Segall, L.2    Prentki, M.3    McGarry, J.D.4    Newgard, C.B.5
  • 34
    • 18344398413 scopus 로고    scopus 로고
    • Characterization of glycerol uptake and glycerol kinase activity in rat hepatocytes cultured under different hormonal conditions
    • Westergaard N, Madsen P, Lundgren K: Characterization of glycerol uptake and glycerol kinase activity in rat hepatocytes cultured under different hormonal conditions. Biochim Biophys Acta 1402:261-268, 1998
    • (1998) Biochim Biophys Acta , vol.1402 , pp. 261-268
    • Westergaard, N.1    Madsen, P.2    Lundgren, K.3
  • 35
    • 9544249496 scopus 로고    scopus 로고
    • Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells
    • Ishihara H, Nakazaki M, Kanegae Y, Inukai K, Asano T, Katagiri H, Yazaki Y, Kikuchi M, Miyazaki J, Saito I, Oka Y: Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells. Diabetes 45:1238-1244, 1996
    • (1996) Diabetes , vol.45 , pp. 1238-1244
    • Ishihara, H.1    Nakazaki, M.2    Kanegae, Y.3    Inukai, K.4    Asano, T.5    Katagiri, H.6    Yazaki, Y.7    Kikuchi, M.8    Miyazaki, J.9    Saito, I.10    Oka, Y.11
  • 38
    • 0033431775 scopus 로고    scopus 로고
    • Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells
    • Ishihara H, Wang H, Drewes LR, Wollheim CB: Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells. J Clin Invest 104:1621-1629, 1999
    • (1999) J Clin Invest , vol.104 , pp. 1621-1629
    • Ishihara, H.1    Wang, H.2    Drewes, L.R.3    Wollheim, C.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.