Transforming growth factor α (TGF-α) expression in dysplastic oral leukoplakia: Modulation by 13-cis retinoic acid

Head and Neck

Volumn 21, Issue 6, 1999, Pages 566-573

  Beenken, Samuel W ^a,c   Sellers, Marty T ^a   Huang, Peter ^a   Peters, Glenn ^a   Krontiras, Helen ^a   Dixon, Pam ^a   Stockard, Cecil ^b   Listinsky, Catherine ^b   Grizzle, William E ^b  

^a Kentucky   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Chemoprevention; Leukoplakia; Retinoids; Surrogate endpoint biomarkers

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ISOTRETINOIN; TRANSFORMING GROWTH FACTOR ALPHA;

CHEMOPROPHYLAXIS; DISEASE MARKER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEUKOPLAKIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SQUAMOUS CELL CARCINOMA; TUMOR BIOPSY;

ANTINEOPLASTIC AGENTS; BIOPSY; CARCINOMA, SQUAMOUS CELL; CHEMOPREVENTION; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOHISTOCHEMISTRY; ISOTRETINOIN; KERATOLYTIC AGENTS; LEUKOPLAKIA, ORAL; MOUTH MUCOSA; PILOT PROJECTS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SINGLE-BLIND METHOD; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR MARKERS, BIOLOGICAL;

EID: 0032847979     PISSN: 10433074     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0347(199909)21:6<566::AID-HED11>3.0.CO;2-H     Document Type: Review

References (37)

1. Farber E. The multistep nature of cancer development. Cancer Res 1984;44:4217-4223.
2. Shin DM, Ro JY, Shah T, Hong WK, Hittelman WN. Dysregulation of epidermal growth factor receptor (EGFR) expression in the multistage process of head and neck carcinogenesis. Cancer Res 1994;54:3153-3159.
3. Shin DM, Kim J, Ro JY, Hittelman J, Roth JA, Hong WK, Hittelman WN. Activation of p53 expression in premalignant lesions during head and neck tumorigenesis. Cancer Res 1994;54:321-326.
4. Stitch HF. Micronucleated exfoliated cells as indicators for genotoxic damage and as markers in chemoprevention trials. J Nutr Growth Cancer 1987;4:9-18.
5. Slaughter DL, Southwick HW, Smejkal, W. "Field cancerization" in oral stratified squamous epithelium: clinical implications of multicentric origin. Cancer 1953;6: 963-968.
6. Gaby SK, Singh VN. Beta-carotene. In: Gaby SK, Bendich A, Singh VN, Machlin LJ, editors. Vitamin intake and health. New York: Marcel Dekker, Inc.; 1991. p 29-57.
7. Lippman SM, Spitz MR, Huber M, Hong WK. Strategies for chemoprevention study of premalignant lesions and second primary tumors in the head and neck. Curr Opin Oncol 1995;7:234.
8. Lippman SM, Hong WK. Retinoid chemoprevention of upper aerodigestive tract carcinogenesis. In: DeVita VT, Hellman S, Rosenberg SA, editors. Important advances in oncology. Philadelphia: Lippincott; 1992. pp 93-109.
9. Vokes EE, Weichselbaum RR, Lippman SM, Hong WK. Head and neck cancer. N Engl J Med 1993;328:184.
10. Koch HF. Biochemical treatment of precancerous oral lesions: The effectiveness of various analogues of retinoic acid. J Oral Maxillofac Surg 1978;6:59-63.
11. Shah JP, Strong EW, DeCosse JJ, et al. Effects of retinoids on oral leukoplakia. Am J Surg 1983;146:466-470.
12. Hong WK, Endicott J, Itri LM. 13-cis Retinoic acid in the treatment of oral leukoplakia. N Engl J Med 1986;315: 1501-1505.
13. Malaker K, Anderson BJ, Beecroft WA, et al. Management of oral mucosal dysplasia with beta-carotene and 13-cis retinoic acid: a pilot crossover study. Cancer Detect Prev 1991;15:335-340.
14. Lotan R, Xu X-C, Lippman S, et al. Suppression of retinoic acid receptor-β in premalignant lesions and its upregulation by isotretinoin. N Engl J Med 1995;332:1405-1410.
15. Hong WK, Lippman SM, Itri LM. Prevention of second primary tumors with isotretinoin in squamous cell carcinoma of the head and neck. N Engl J Med 1990;323: 795-801.
16. Brenner SE, Pajak TF, Lippman SM, et al. Prevention of second primary tumors with isotretinoin in patients with squamous cell carcinoma of the head and neck: long term follow-up. JNCI 1993;86:140-141.
17. Beenken, SW, Huang, P, Sellers, MS, et al. Retinoid modulation of biomarkers in oral leukoplakia/dysplasia. J Cell Biochem 1994;19(Suppl):270-277.
18. McGeady ML, Kerby S, Shankar V, et al. Infection with a TGF-α retroviral vector transforms normal mouse mammary epithelial cells but not normal rat fibroblasts. Oncogene 1989;4:1375-1382.
19. Derynk R, Goeddel DV, Ullrich A. Synthesis of messenger RNAs for transforming growth factors-α and -β and the epidermal growth factor receptor by human tumors. Cancer Res 1987;47:707-712.
20. Partridge M, Green MR, Langdon JD, et al. Production of TGF-α and TGF-β by altered keratinocytes, skin and oral squamous cell carcinomas: potential autocrine regulation of normal and malignant epithelial cell production. Br J Cancer 1989;60:542-548.
21. Yoshida K, Kyo E, Tsuda T. EGF and TGF-α, the ligands of hyperproduced EGFR in human esophageal carcinoma cells, act as autocrine growth factors. Int J Cancer 1990; 45:131-135.
22. Todd R, Donoff BR, Gertz R. TGF-α and EGF receptor mRNAs in human oral cancers. Carcinogenesis 1989;10: 1553-1556.
23. Welchselbaum RR, Dunphy EJ, Beckett MA, et al. Epidermal growth factor gene amplification and expression in head and neck cancer cell lines. Head Neck 1989;11: 437-442.
24. Shirasuna K, Hayashido Y, Sugiyama M, et al. Immunohistochemical localization of epidermal growth factor (EGF) and EGF receptor in human oral mucosa and its malignancy. Virchows Arch Pathol Anat 1991;418: 349-353.
25. Kawamoto T, Takahashi K, Nishi M, et al. Quantitative assay of epidermal growth factor receptor in human squamous cell carcinomas of the oral region by an avidin-biotin method. Jpn J Cancer Res 1991;82:403-410.
26. Maxwell SA, Sacks PG, Gutterman JU, et al. Epidermal growth factor receptor protein-tyrosine kinase activity in human cell lines established from squamous cell carcinoma of the head and neck. Cancer Res 1989;49: 1130-1137.
27. Grandis JR, Tweardy DJ. TGF-α and EGFR in head and neck cancer. J Cellular Biochem 1993;17F:188-191.
28. Grandis JR, Tweardy DJ. Elevated levels of transforming growth factor-α and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res 1993;53:3579-3584.
29. Grandis JR, Melhem MF, Barnes EL, Tweardy DJ. Quantitative immunohistochemical analysis of transforming growth factor-α and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck. Cancer 1996;78:1284-1292.
30. Grandis RJ, Zeng Q, Tweardy DJ. Retinoic acid normalizes the increased gene transcription rate of TGF-α and EGFR in head and neck cancer cell lines. Nature 1996;2: 237-240.
31. Gudas LJ, Sporn MB, Roberts AB. Cellular biology and biochemistry of the retinoids. In: Sporn MB, Roberts AB, Goodman DS, editors. The retinoids: biology, chemistry, and medicine. New York: Raven Press; 1994. pp 443-520.
32. Morriss-Kay G. Retinoic acid receptors in normal growth and development. Cancer Surv 1992;14:181-193.
33. Chambon P. The retinoid signaling pathway: molecular and genetic analyses. Semin Cell Biol 1994;5:115-125.
34. Gudas LJ. Retinoids, retinoid-responsive genes, cell differentiation, and cancer. Cell Growth Differ 1992;3:655-662.
35. Mangelsdorf DJ, Umesono K, Evans RM. The retinoid receptors. In: Sporn MB, Roberts AB, Goodman DS, editors. The retinoids: biology, chemistry, and medicine. New York: Raven Press; 1994. pp 319-349.
36. Pfahl M. Vertebrate receptors: molecular biology, dimerization and response elements. Semin Cell Biol 1994;5:95-103.
37. de The H, Vivanco-Ruiz MDM, Tiollais P, Stunnenberg H, Dejean A. Identification of a retinoic acid responsive element in the retinoic acid receptor-B gene. Nature 1990; 343:177-180.