Preventing estrogen receptor action with dimer-interface peptides

Steroids

Volumn 66, Issue 7, 2001, Pages 549-558

  Yudt, Matthew R ^a   Koide, Shohei ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Estrogen receptor; Helical peptides; Protein aggregation; Protein dimerization; Rational design; Steroid

Indexed keywords

4 HYDROXYTAMOXIFEN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FULVESTRANT; PEPTIDE; PROMEGESTONE;

ARTICLE; CELL STRAIN MCF 7; CIRCULAR DICHROISM; CONTROLLED STUDY; DIMERIZATION; DNA BINDING; HORMONE BINDING; HUMAN; HUMAN CELL; LIGAND BINDING; PEPTIDE SYNTHESIS; PRECIPITATION; PROTEIN AGGREGATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; WESTERN BLOTTING;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; DIMERIZATION; DRUG DESIGN; ESTROGEN RECEPTOR ALPHA; HUMANS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PRECIPITATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ESTROGEN; SUBSTRATE SPECIFICITY;

EID: 0035400820     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(00)00224-5     Document Type: Article

References (46)

1. The steroid and thyroid hormone receptor superfamily
2. Functional domains of the human estrogen receptor
3. Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor
4. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors
5. The crystal structure of the estrogen receptor DNA-binding domain bound to DNA; how receptors discriminate between their response elements
6. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
7. A canonical structure for the ligand-binding domain of nuclear receptors
8. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
9. Molecular basis of agonism and antagonism in the oestrogen receptor
10. Coactivators and corepressors as mediators of nuclear receptor function; an update
11. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
12. The molecular mechanism of the in vitro 4 S to 5 S transformation of the uterine estrogen receptor
13. Pharmacodynamic and biological effects of anti-estrogens in different models
14. Insights from the study of animals lacking functional estrogen receptor
15. Hormonal strategies for breast cancer; a new focus on the estrogen receptor as a therapeutic target
16. Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse
17. Antiestrogenic action of raloxifene and tamoxifen; today and tomorrow
18. An analysis of tamoxifen-stimulated human carcinomas for mutations in the AF-2 region of the estrogen receptor
19. Specific inhibition of herpesvirus ribonucleotide reductase by synthetic peptides
20. Inhibition of HIV1 reverse transcriptase dimerization using synthetic peptides derived from the connection domain
21. The inhibition of human immunodeficiency virus proteases by 'interface peptides'
22. Synthetic interface peptides as inactivators of multimeric enzymes; inhibitory and conformational properties of three fragments from Lactobacillus casei thymidylate synthase
23. An antiestrogen; a phosphotyrosyl peptide that blocks dimerization of the human estrogen receptor
24. Hormone- and DNA-binding mechanisms of the recombinant human estrogen receptor
25. Immunocytochemical localization of androgen receptor with polyclonal antibody in paraffin-embedded human tissues
26. Cloning of the human oestrogen receptor cDNA
27. Identification of 3′,5′-cyclic adenosine monophosphate response element and other cis-acting elements in the human androgen receptor gene promoter
28. Determination of the helix and beta form of proteins in aqueous solution by circular dichroism
29. Estrogen receptor phosphorylation. Hormonal dependence and consequence on specific DNA binding
30. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains
31. Transcriptional activation and dimerization functions in the human vitamin D receptor
32. A domain containing leucine-zipper-like motifs mediate novel in vivo interactions between the thyroid hormone and retinoic acid receptors
33. Two distinct dimerization interfaces differentially modulate target gene specificity of nuclear hormone receptors
34. Identification of critical residues for heterodimerization within the ligand-binding domain of retinoid X receptor
35. Elucidating the folding problem of helical peptides using empirical parameters
36. Helix stability in barstar peptides
37. A 22-amino-acid peptide restores DNA-binding activity to dimerization-defective mutants of the estrogen receptor
38. Structural characterization of a short peptide fragment that mediates estrogen-receptor dimerization
39. Atomic structure of progesterone complexed with its receptor
40. Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes
41. The interaction of human estrogen receptor with DNA is modulated by receptor-associated proteins
42. MOLSCRIPT; a program to produce both detailed and schematic plots of protein structures
43. Protein folding and association; insights from the interfacial and thermodynamic properties of hydrocarbons
44. Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries; discovery of peptide antagonists of estrogen receptors alpha and beta
45. Peptide antagonists of the human estrogen receptor