Critical target and dose and dose-rate responses for the induction of chromosomal instability by ionizing radiation

Radiation Research

Volumn 151, Issue 6, 1999, Pages 677-685

  Limoli, Charles L ^a   Corcoran, James J ^a   Milligan, Jamie R ^b   Ward, John F ^b   Morgan, William F ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; DNA;

ANIMAL CELL; ARTICLE; CHROMOSOME ABERRATION; DOSE RESPONSE; FLUORESCENCE IN SITU HYBRIDIZATION; GAMMA RADIATION; GENOME; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; X IRRADIATION; X RAY;

NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER;

ANIMALS; BROMODEOXYURIDINE; CELL SURVIVAL; CELLS, CULTURED; CHROMOSOMES; CRICETINAE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; X-RAYS;

ANIMALIA;

EID: 0032977357     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3580206     Document Type: Article

References (40)

1. W. F. Morgan, J. P. Day, M. I. Kaplan, E. M. McGhee and C. L. Limoli, Genomic instability induced by ionizing radiation. Radiat. Res. 146, 247-258 (1996).
2. W. K. Sinclair, X-ray-induced heritable damage (small-colony formation) in cultured mammalian cells. Radiat. Res. 21, 584-611 (1964).
3. C. B. Seymour, C. Mothersill and T. Alper, High yields of lethal mutations in somatic mammalian cells that survive ionizing radiation. Int. J. Radiat. Biol. 50, 167-179 (1986).
4. W. P. Chang and J. B. Little, Delayed reproductive death in x-irradiated Chinese hamster ovary cells. Int. J. Radiat. Biol. 60, 483-496 (1991).
5. P. Hahn, B. Nevaldine and W. F. Morgan, X-ray induction of methotrexate resistance due to dhfr gene amplification. Somat. Cell Mol. Genet. 16, 413-423 (1990).
6. J. C. Ruiz and G. M. Wahl, Chromosomal destabilization during gene amplification. Mol. Cell. Biol. 10, 3056-3066 (1990).
7. W. P. Chang and J. B. Little, Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving x-irradiation: Association with delayed reproductive death phenotype. Mutat. Res. 270, 191-199 (1992).
8. J. B. Little, H. Nagasawa, T. Pfenning and H. Vetrovs, Radiation-induced genomic instability: Delayed mutagenic and cytogenetic effects of X rays and alpha particles. Radiat. Res. 148, 299-307 (1997).
9. M. Jamali and K. R. Trott, Increased micronucleus frequency in the progeny of irradiated Chinese hamster cells. Int. J. Radiat. Biol. 69, 301-307 (1996).
10. L. Manti, M. Jamali, K. M. Prise, B. D. Michael and K. R. Trott, Genomic instability in Chinese hamster cells after exposure to X rays or alpha particles of different mean linear energy transfer. Radiat. Res. 147, 22-28 (1997).
11. B. Ponnaiya, M. N. Cornforth and R. L. Ullrich, Induction of chromosomal instability in human mammary cells by neutrons and gamma rays. Radiat. Res. 147, 288-294 (1997).
12. B. Ponnaiya, M. N. Cornforth and R. L. Ullrich, Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: The difference is as clear as black and white. Radiat. Res. 147, 121-125 (1997).
13. M. A. Kadhim, D. A. Macdonald, D. T. Goodhead, S. A. Lorimore, S. J. Marsden and E. G. Wright, Transmission of chromosomal instability after plutonium α-particle irradiation. Nature 355, 738-740 (1992).
14. K. Holmberg, S. Falt, A. Johansson and B. Lambert, Clonal chromosome aberrations and genomic instability in x-irradiated human T-lymphocyte cultures. Mutat. Res. 286, 321-330 (1993).
15. B. A. Marder and W. F. Morgan, Delayed chromosomal instability induced by DNA damage. Mol. Cell. Biol. 13, 6667-6677 (1993).
16. M. B. Martins, L. Sabatier, M. Ricoul, A. Pinton and B. Dutrillaux, Specific chromosome instability induced by heavy ions: A step towards transformation of human fibroblasts? Mutat. Res. 285, 229-237 (1993).
17. C. L. Limoli, M. I. Kaplan, J. W. Phillips, G. M. Adair and W. F. Morgan, Differential induction of chromosomal instability by DNA strand-breaking agents. Cancer Res. 57, 4048-4056 (1997).
18. S. A. Lorimore, M. A. Kadhim, D. A. Pocock, D. Papworth, D. L. Stevens, D. T. Goodhead and E. G. Wright, Chromosomal instability in the descendants of unirradiated surviving cells after alpha-particle irradiation. Proc. Natl. Acad. Sci. USA 95, 5730-5733 (1998).
19. C. L. Limoli, M. I. Kaplan, J. Corcoran, M. Meyers, D. A. Boothman and W. F. Morgan, Chromosomal instability and its relationship to other endpoints of genomic instability. Cancer Res. 57, 5557-5563 (1997).
20. A. Deshpande, E. H. Goodwin, S. M. Bailey, B. L. Marrone and B. E. Lehnen, Alpha-particle-induced sister chromatid exchange in normal human lung fibroblasts: Evidence for an extranuclear target. Radiat. Res. 145, 260-267 (1996).
21. B. E. Lehnert and E. H. Goodwin, Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells. Cancer Res. 57, 2164-2171 (1997).
22. C. Mothersill and C. Seymour, Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int. J. Radiat. Biol. 71, 421-427 (1997).
23. C. Mothersill and C. B. Seymour, Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: Evidence for release during irradiation of a signal controlling survival into the medium. Radiat. Res. 149, 256-262 (1998).
24. J. D. Zimbrick, J. F. Ward and L. S. Myers, Jr., Studies on the chemical basis of cellular radiosensitization by 5-bromouracil substitution in DNA. I. Pulse- and steady-state radiolysis of 5-bromouracil and thymine. Int. J. Radiat. Biol. 16, 505-523 (1969).
25. J. D. Zimbrick, J. F. Ward and L. S. Myers, Jr., Studies on the chemical basis of cellular radiosensitization by 5-bromouracil substitution in DNA. II. Pulse- and steady-state radiolysis of bromouracil-substituted and unsubstituted DNA. Int. J. Radiat. Biol. 16, 525-534 (1969).
26. F. Hutchinson, The lesions produced by ultraviolet light in DNA containing 5-bromouracil. Q. Rev. Biophys. 6, 201-246 (1973).
27. C. L. Limoli and J. F. Ward, A new method of introducing double-strand breaks into cellular DNA. Radiat. Res. 134, 160-169 (1993).
28. J. D. Tucker, W. F. Morgan, A. A. Awa, M. Bauchinger, D. Blakey, M. N. Cornforth, L. G. Littlefield, A. T. Natarajan and C. Shasserre, A proposed system for scoring structural aberrations detected by chromosome painting. Cytogenet. Cell Genet. 68, 211-221 (1995).
29. W. F. Morgan and J. P. Murnane, A role for genomic instability in cellular radioresistance? Cancer Metastasis Rev. 14, 49-58 (1995).
30. S. A. Glantz, Primer of Biostatistics, 3rd ed. McGraw-Hill, San Francisco, 1992.
31. T. S. Lawrence, M. A. Davis, J. Maybaum, P. L. Stetson and W. D. Ensminger, The dependence of halogenated pyrimidine incorporation and radiosensitization on the duration of drug exposure. Int. J. Radiat Oncol. Biol. Phys. 1822, 1393-1398 (1989).
32. L. L. Ling and J. F. Ward, Radiosensitization of Chinese hamster V79 cells by bromodeoxyuridine substitution of thymidine: Enhancement of radiation-induced toxicity and DNA strand break production by monofilar and bifilar substitution. Radiat. Res. 121, 76-83 (1990).
33. C. L. Limoli and J. F. Ward, Response of bromodeoxyuridine-substituted Chinese hamster cells to UVA light exposure in the presence of Hoechst dye 33258: Survival and repair studies. Radiat. Res. 138, 312-319 (1994).
34. G. Iliakis, Y. Wang, G. E. Pantelias and L. Metzger, Mechanism of radiosensitization by halogenated pyrimidines: Effects of BrdU on repair of DNA breaks, interphase chromatin breaks, and potentially lethal damage in plateau-phase CHO cells. Radiat. Res. 129, 202-211 (1992).
35. C. L. Limoli, J. P. Day, J. F. Ward and W. F. Morgan, Induction of chromosome aberrations and delayed genomic instability by photochemical processes. Photochem. Photobiol. 67, 233-238 (1998).
36. M. I. Kaplan and W. F. Morgan, The nucleus is the target for radiation-induced chromosomal instability. Radiat. Res. 150, 382-390 (1998).
37. M. A. Walicka, S. J. Adelstein and A. I. Kassis, Indirect mechanisms contribute to biological effects produced by decay of DNA-incorporated iodine-125 in mammalian cells in vitro: Clonogenic survival. Radiat. Res. 149, 142-146 (1998).
38. M. A. Walicka, S. J. Adelstein and A. I. Kassis, Indirect mechanisms contribute to biological effects produced by decay of DNA-incorporated iodine-125 in mammalian cells in vitro: Double-strand breaks. Radiat. Res. 149, 134-141 (1998).
39. B. Lambert, K. Holmberg, P. Hackman and A. Wennborg, Radiation induced chromosomal instability in human T-lymphocytes. Mutat. Res. 405, 161-170 (1998).
40. M. A. Kadhim, S. J. Marsden and E. G. Wright, Radiation-induced chromosomal instability in human fibroblasts: Temporal effects and the influence of radiation quality. Int. J. Radiat. Biol. 73, 143-148 (1998).