Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase

Archives of Biochemistry and Biophysics

Volumn 391, Issue 1, 2001, Pages 72-78

  Song, L ^a   Xu, M ^a   Lopes Virella, M F ^a   Huang, Y ^a  

^a RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

Endothelium; Expression; Metalloproteinase; Quercetin

Indexed keywords

INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE; OXIDIZED LOW DENSITY LIPOPROTEIN; QUERCETIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ARTICLE; ATHEROSCLEROTIC PLAQUE; ENDOTHELIUM CELL; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; ISCHEMIC HEART DISEASE; PRIORITY JOURNAL;

EID: 0035398946     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.2001.2402     Document Type: Article

References (35)

1. Potential health effects of the dietary flavonol quercetin
2. Review of the biology of quercetin and related bioflavonoids
3. Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures
4. Polyphenolic flavonols as scavengers of aqueous phase radicals and as chain-braking antioxidants
5. The bioavailability of non-untrient plant factors: Dietary flavonoids and phyto-oestrogens
6. Absorption and antioxidant effects of quercetin from onions, in man
7. The pathogenesis of coronary artery disease and the acute coronary syndromes
8. Characterization of the relative thrombogenicity of atherosclerotic plaque components: Implications for consequences of plaque rupture
9. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
10. Molecular bases of the acute coronary syndromes
11. The matrix-degrading metalloproteinases
12. Tissue inhibitors of metalloproteinases and metalloproteinases in atherosclerosis
13. Interstitial collagenase is required for antiogenesis in vitro
14. Collagen polymorphism in the normal and diseased blood vessel wall. Investigation of collagens types I, III and V
15. Quantitation of type I to type III collagen ratios in small samples of human tendon, blood vessels, and atherosclerotic plaques
16. Immunohistochemical study of intimal microvessels in coronary atherosclerosis
17. Hypothesis: Vasa vasorum and neovascularisation of human coronary arteries. Possible role in the pathophysiology of atherosclerosis
18. The possible role of the arterial microcirculation in the pathogenesis of atherosclerosis
19. Leucocyte recruitment in rupture prone regions of lipid-rich plaques: A prominent role for neovascularization?
20. Oxidized LDL stimulates matrix metalloproteinase-1 expression in human vascular endothelial cells
21. Protein measurement with the folin phenol reagent
22. Oxidized LDL differentially regulates MMP-1 and TIMP-1 expression in human vascular endothelial cells
23. Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases
24. Fc gamma receptor cross-linking by immune complexes induces matrix metalloproteinase-1 in U937 cells via mitogen-activated protein kinase cascade
25. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: A potential mechanism of lesion stabilization
26. Rabbit and human atherosclerotic lesions contain IgG that recogizes epitopes of oxidized LDL
27. Selective loss of PMA-stimulated expression of matrix metalloproteinase-1 in HaCaT keratinocytes is correlated with the inability to induce mitogen-activated protein family kinase
28. Extracellular signal-regulated kinase 1/2-mediated phosphorylation of JunD and FosB is required for okadaic acid-induced activator protein 1 activation
29. Tumor-derived EMMPRIN (extracellular matrix metalloproteinase inducer) stimulates collagenase transcription through MAPK p38
30. Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase
31. Protein kinase C inhibition by flavonoids. Kinetic mechanisms and structure-activity relationships
32. Inhibition of the calcium- and phospholipid-dependent protein kinase activity from brain mouse cytosol by quercetin
33. Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: Inhibition by quercetin
34. Quercetin sensitizes RBL-2H3 cells to polybasic mast cells secretagogues through increased expression of Gi GTP-binding proteins linked to a phospholipase C signaling pathway
35. Identification of a serum- and phorbol ester-responsive element in the murine tissue inhibitor of metalloproteinase gene