Proteomics - Post-genomic cartography to understand gene function

Trends in Pharmacological Sciences

Volumn 22, Issue 7, 2001, Pages 376-384

  Naaby Hansen, Soren ^a   Waterfield, Michael D ^a   Cramer, Rainer ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENT DYE Y; PROTEOME; UNCLASSIFIED DRUG;

CAENORHABDITIS ELEGANS; DATA BASE; FOURIER TRANSFORMATION; GENE FUNCTION; GENE SEQUENCE; GENOME; HUMAN; ISOELECTRIC FOCUSING; MASS SPECTROMETRY; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; REVIEW; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ANIMALS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; MASS SPECTROMETRY; PEPTIDE MAPPING; PROTEOME; SEQUENCE TAGGED SITES; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 0035397916     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01663-1     Document Type: Review

References (63)

1. A comparison of selected mRNA and protein abundances in human liver
2. Correlation between protein and mRNA abundance in yeast
3. Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties
4. Human and mouse proteomic databases: Novel resources in the protein universe
5. Proteosome and proteomics: New technologies, new concepts, and new words
6. The dynamic range of protein expression: A challenge for proteomic research
7. Differential detergent fractionation of eukaryotic cells
8. Enrichment of hydrophobic proteins via Triton X-114 phase partitioning and hydroxyapatite column chromatography for mass spectrometry
9. Construction of a directory of tobacco plasma membrane proteins by combined two-dimensional gel electrophoresis and protein sequencing
10. Biochemical analysis of membrane proteins from an early maturation stage of phagosomes
11. Subcellular fractionation, electromigration analysis and mapping of organelles
12. Detection of proteins on 2D electrophoresis gels
13. A thousand points of light: The application of fluorescence detection technologies to two-dimensional gel electrophoresis and proteomics
14. Difference gel electrophoresis: A single gel method for detecting changes in protein extracts
15. Improved protein solubility in two-dimensional electrophoresis using tributyl phosphine as reducing agent
16. Improvement of the solubilization of proteins in two-dimensional electrophoresis with immobilized pH gradients
17. New zwitterionic detergents improve the analysis of membrane proteins by 2-D electrophoresis
18. Isoelectric focusing in immobilized pH gradients: An update
19. Proteomic analysis of the Escherichia coli outer membrane
20. Two-dimensional gel electrophoretic analysis of vectorially labeled surface proteins of human spermatozoa
21. The current state of two-dimensional electrophoresis with immobilized pH gradients
22. Linking genome and proteome by mass spectrometry: Large-scale identification of yeast proteins from two dimensional gels
23. Mass spectrometry and the age of the proteome
24. Protein identification methods in proteomics
25. Database searching using mass spectrometry data
26. Post-source decay analysis in matrix-assisted laser desorption/ionization mass spectrometry of biomolecules
27. Proteome research: Complementarity and limitations with respect to the RNA and DNA worlds
28. Quantitative analysis of complex protein mixtures using isotope-coded affinity tags
29. Sample handling for proteome analysis
30. A peptide concentration and purification method for protein characterization in the subpicomole range using matrix-assisted laser desorption/ionization-postsource decay (MALDI-PSD) sequencing
31. Orthogonal acceleration time-of-flight mass spectrometry
32. Fourier transform ion cyclotron resonance mass spectrometry: A primer
33. MALDI quadrupole time-of-flight mass spectrometry: A powerful tool for proteomic research
34. IR-MALDI - Softer ionization in MALDI-MS for studies of labile macromolecules
35. Charge derivatization of peptides to simplify their sequencing with an ion trap mass spectrometer
36. A method for high-sensitivity peptide sequencing using postsource decay matrix-assisted laser desorption ionization mass spectrometry
37. Localization of O-glycosylation sites in peptides by electron capture dissociation in a Fourier transform mass spectrometer
38. Electron capture dissociation for structural characterization of multiply charged protein cations
39. ProFound: An expert system for protein identification using mass spectrometric peptide mapping information
40. Improvements in protein identification by MALDI-TOF-MS peptide mapping
41. A generic protein purification method for protein complex characterization and proteome exploration
42. Immobilized gallium (III) affinity chromatography of phosphopeptides
43. Affinity maturation of a Taq DNA polymerase specific affibody by helix shuffling
44. Mapping signal transduction pathways by phage display
45. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae
46. Identification of in vitro substrates of the chaperonin GroEL
47. Protein microarrays for gene expression and antibody screening
48. Molecular profiling of human cancer
49. Interactions of E. coli RNA with bacteriophage MS2 coat protein: Genomic SELEX
50. Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry
51. Biosensor chip mass spectrometry: A chip-based proteomic approach
52. The integration of SPR biosensors with mass spectrometry: Possible applications for proteome analysis
53. Functional proteomics analysis of signal transduction pathways of the platelet-derived growth factor β receptor
54. Psoriasin (S100A7): A putative urinary marker for the follow-up of patients with bladder squamous cell carcinomas
55. Bovine dialted cardiomyopathy: Proteomic analysis of an animal model of human dilated cardiomyopathy
56. Proteomics to display lovastatin-induced protein and pathway regulation in rat liver
57. The effects of peroxisome proliferators on protein abundances in mouse liver
58. Alterations in rabbit kidney protein expression following lead exposure as analyzed by two-dimensional gel electrophoresis
59. New insights into cyclosporine A nephrotoxicity by proteome analysis
60. Comparative analysis of the hippocampus implicates chromosome 6q in schizophrenia
61. Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex
62. Comprehensive two-dimensional high-performance liquid chromatography for the isolation of overexpressed proteins and proteome mapping
63. Proposal of a common nomenclature for sequence ions in mass spectra of peptides