Effect of overexpression of human Cu/Zn-SOD on activation-induced lymphocyte proliferation and apoptosis

Free Radical Biology and Medicine

Volumn 30, Issue 11, 2001, Pages 1319-1327

  Pahlavani, Mohammad A ^a   Mele, James F ^a   Richardson, Arlan ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Cu Zn SOD; Free radicals; Mitogenesis; Transgenic mice

Indexed keywords

CD3 ANTIGEN; CONCANAVALIN A; COPPER ZINC SUPEROXIDE DISMUTASE; DNA FRAGMENT; LIPOPOLYSACCHARIDE; MITOGENIC AGENT; THYMIDINE; TRITIUM;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FLOW CYTOMETRY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPECTROFLUOROMETRY; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD95; APOPTOSIS; CELL DIVISION; CELLS, CULTURED; CONCANAVALIN A; FAS LIGAND PROTEIN; FLOW CYTOMETRY; HUMANS; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, TRANSGENIC; SPLEEN; SUPEROXIDE DISMUTASE; T-LYMPHOCYTES;

EID: 0035371529     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00529-9     Document Type: Article

References (71)

1. Barber D.A., Harris S.R. Oxygen free radicals and antioxidants a review. Am. Pharm. 34:1994;26-35.
2. Singh K. Oxidants, antioxidants and diseases - a brief review. Indian J. Med. Sci. 51:1997;226-230.
3. Knight J.A. Review free radicals, antioxidants, and the immune system. Ann. Clin. Lab Sci. 30:2000;145-158.
4. Bendich A. Physiological role of antioxidants in the immune system. J. Dairy Sci. 76:1993;2789-2794.
5. Schreck R., Rieber P., Baeuerle P.A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κ B transcription factor and HIV-1. EMBO J. 10:1991;2247-2258.
6. 2 for platelet-derived growth factor signal transduction. Science. 270:1995;296-299.
7. Halliwell B., Gutteridge J.M. Role of free radicals and catalytic metal ions in human disease an overview. Methods. Enzymol. 186:1990;1-85.
8. Ames B.N., Shigenaga M.K., Hagen T.M. Oxidants, antioxidants, and degenerative diseases of aging. Proc. Natl. Acad. Sci. USA. 90:1993;7915-7922.
9. Miller R.A., Britigan B.E. The formation and biological significance of phagocyte-derived oxidants. J. Investig. Med. 43:1995;39-49.
10. Schraufstatter I.U., Hyslop P.A., Jackson J., Cochrane C.G. Oxidant-induced DNA damage of target cells. J. Clin. Invest. 82:1988;1040-1050.
11. El-Hag A., Lipsky P.E., Bennett M., Clark R.A. Immunomodulation by neutrophil myeloperoxidase and hydrogen peroxide: Differential susceptibility of human lymphocytes functions. J. Immunol. 136:1986;3420.
12. Buttke T.M., Sandstrom P.A. Oxidative stress as a mediator of apoptosis. Immunol. Today. 15:1994;7-10.
13. Droge W., Mihm S., Bockstette M., Roth S. Effect of reactive oxygen intermediates and antioxidant on proliferation and function of T lymphocytes. Methods Enzymol. 234:1994;135-151.
14. Fridovich I. Biological effects of the superoxide radical. Arch. Biochem. Biophys. 247:1986;1-11.
15. Fridovich I. Superoxide dismutases. Adv. Enzymol. Relat. Areas Mol. Biol. 58:1986;61-97.
16. Marklund S.L., Holme E., Hellner L. Superoxide dismutase in extracellular fluids. Clin. Chim. Acta. 126:1982;41-51.
17. Marklund S.L. Extracellular superoxide dismutase in human tissues and human cell lines. J. Clin. Invest. 74:1984;1398-1403.
18. Oury T.D., Chang L.Y., Marklund S.L., Day B.J., Crapo J.D. Immunocytochemical localization of extracellular superoxide dismutase in human lung. Lab. Invest. 70:1994;889-898.
19. Elroy-Stein O., Bernstein Y., Groner Y. Overproduction of human Cu/Zn-superoxide dismutase in transfected cells extenuation of paraquat-mediated cytotoxicity and enhancement of lipid peroxidation. EMBO J. 5:1986;615-622.
20. Jordan J., Ghadge G.D., Prehn J.H., Toth P.T., Roos R.P., Miller R.J. Expression of human copper/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth factor. Mol. Pharmacol. 47:1995;1095-1100.
21. Pahlavani M.A., Van Remmen H. New directions for studying the role of free radicals in aging. AGE. 20:1997;151-163.
22. Vanfleteren J.R. Oxidative stress and ageing in Caenorhabditis elegans. Biochem. J. 292:1993;605-608.
23. Reveillaud I., Niedzwiecki A., Bensch K.G., Fleming J.E. Expression of bovine superoxide dismutase in Drosophila melanogaster augments resistance of oxidative stress. Mol. Cell Biol. 11:1991;632-640.
24. Przedborski S., Khan U., Kostic V., Carlson E., Epstein C.J., Sulzer D. Increased superoxide dismutase activity improves survival of cultured postnatal midbrain neurons. J. Neurochem. 67:1996;1383-1392.
25. Elroy-Stein O., Groner Y. Impaired neurotransmitter uptake in PC12 cells overexpressing human Cu/Zn-superoxide dismutase - implication for gene dosage effects in Down syndrome. Cell. 52:1988;259-267.
26. Avraham K.B., Schickler M., Sapoznikov D., Yarom R., Groner Y. Down's syndrome abnormal neuromuscular junction in tongue of transgenic mice with elevated levels of human Cu/Zn-superoxide dismutase. Cell. 54:1988;823-829.
27. Peled-Kamar M., Lotem J., Wirguin I., Weiner L., Hermalin A., Groner Y. Oxidative stress mediates impairment of muscle function in transgenic mice with elevated level of wild-type Cu/Zn superoxide dismutase. Proc. Natl. Acad. Sci. USA. 94:1997;3883-3887.
28. Yarom R., Sapoznikov D., Havivi Y., Avraham K.B., Schickler M., Groner Y. Premature aging changes in neuromuscular junctions of transgenic mice with an extra human CuZnSOD gene a model for tongue pathology in Down's syndrome. J. Neurol. Sci. 88:1988;41-53.
29. Schickler M., Knobler H., Avraham K.B., Elroy-Stein O., Groner Y. Diminished serotonin uptake in platelets of transgenic mice with increased Cu/Zn-superoxide dismutase activity. EMBO J. 8:1989;1385-1392.
30. Sinet P.M. Metabolism of oxygen derivatives in Down's syndrome. Ann. N. Y. Acad. Sci. 396:1982;83-94.
31. Groner Y., Lieman-Hurwitz J., Dafni N., Sherman L., Levanon D., Bernstein Y., Danciger E., Elroy-Stein O. Molecular structure and expression of the gene locus on chromosome 21 encoding the Cu/Zn superoxide dismutase and its relevance to Down syndrome. Ann. N. Y. Acad. Sci. 45:1985;133-156.
32. Nabarra B., Casanova M., Paris D., Nicole A., Toyama K., Sinet P.M., Ceballos I., London J. Transgenic mice overexpressing the human Cu/Zn-SOD gene ultrastructural studies of a premature thymic involution model of Down's syndrome (trisomy 21). Lab. Invest. 74:1996;617-626.
33. Nabarra B., Casanova M., Paris D., Paly E., Toyoma K., Ceballos I., London J. Premature thymic involution, observed at the ultrastructural level, in two lineages of human-SOD-1 transgenic mice. Mech. Ageing Dev. 96:1997;59-73.
34. Pawelec G., Remarque E., Barnett Y., Solana R. T cells and aging. Front. Biosci. 3:1998;D59-D99.
35. Beauchamp C., Fridovich I. Superoxide dismutase improved assays and an assay applicable to acrylamide gel. Anal. Biochem. 44:1971;276-279.
36. Pahlavani M.A., Cheung T.H., Chesky J.A., Richardson A. Influence of exercise on the immune function of rats of various ages. J. Appl. Physiol. 64:1988;1997-2001.
37. Pahlavani M.A., Richardson A. Age-related decrease in the naive (OX22+) T cells in F344 rats. Mech. Ageing Dev. 74:1994;171-176.
38. Radvanyi L.G., Mills G.B., Miller R.G. Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death. J. Immunol. 150:1993;5704-5715.
39. Duke R.C., Cohen J.J. Morphological and biochemical assays of apoptosis. Coligan J.E., Kruisbeek A.M., Margulies D.H., Shevac E.M., Strober W. Current protocols in immunology. 1992;3.17.1-3.17.16 John Wiley & Sons, New York.
40. Herrmann M., Lorenz H.M., Voll R., Grunke M., Woith W., Kalden J.R. A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res. 22:1994;5506-5507.
41. Ferlini C., Di Cesare S., Rainaldi G., Malorni W., Samoggia P., Biselli R., Fattorossi A. Flow cytometric analysis of the early phases of apoptosis by cellular and nuclear techniques. Cytometry. 24:1996;106-115.
42. Peled-Kamar M., Lotem J., Okon E., Sachs L., Groner Y. Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overexpressing Cu/Zn-superoxide dismutase: Implications for Down syndrome. EMBO J. 14:1995;4985-4993.
43. Yang G., Chan P.H., Chen J., Carlson E., Chen S.F., Weinstein P., Epstein C.J., Kamii H. Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke. 25:1994;165-170.
44. Scott M.D., Meshnick S.R., Eaton J.W. Superoxide dismutase amplifies organismal sensitivity to ionizing radiation. J. Biol. Chem. 264:1989;2498-2501.
45. Przedborski S., Kostic V., Jackson-Lewis V., Naini A.B., Simonetti S., Fahn S., Carlson E., Epstein C.J., Cadet J.L. Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced neurotoxicity. J. Neurosci. 12:1992;1658-1667.
46. Greenlund L.J., Deckwerth T.L., Johnson E.M. Superoxide dismutase delays neuronal apoptosis a role for reactive oxygen species in programmed neuronal death. Neuron. 14:1995;303-315.
47. Avraham K.B., Schickler M., Sapoznikov D., Yarom R., Groner Y. Down's syndrome abnormal neuromuscular junction in tongue of transgenic mice with elevated levels of human Cu/Zn-superoxide dismutase. Cell. 54:1988;823-829.
48. Beal M.F., Ferrante R.J., Henshaw R., Matthews R.T., Chan P.H., Kowall N.W., Epstein C.J., Schulz J.B. 3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice. J. Neurochem. 65:1995;919-922.
49. Chan P.H., Yang G.Y., Chen S.F., Carlson E., Epstein C.J. Cold-induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn-superoxide dismutase. Ann. Neurol. 29:1991;482-486.
50. Mirochnitchenko O., Inouye M. Effect of overexpression of human Cu, Zn superoxide dismutase in transgenic mice on macrophage functions. J. Immunol. 156:1996;1578-1586.
51. Bruijn L.I., Beal M.F., Becher M.W., Schulz J.B., Wong P.C., Price D.L., Cleveland D.W. Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. Proc. Natl. Acad. Sci. USA. 94:1997;7606-7611.
52. Golenser J., Peled-Kamar M., Schwartz E., Friedman I., Groner Y., Pollack Y. Transgenic mice with elevated level of CuZnSOD are highly susceptible to malaria infection. Free Radic. Biol. Med. 24:1998;1504-1510.
53. Goldstone S.D., Milligan A.D., Hunt N.H. Oxidative signaling and gene expression during lymphocyte activation. Biochim. Biophys. Acta. 1314:1996;175-182.
54. Lowe G.M., Hulley C.E., Rhodes E.S., Young A.J., Bilton R.F. Free radical stimulation of tyrosine kinase and phosphatase activity in human peripheral blood mononuclear cells. Biochem. Biophys. Res. Commun. 245:1998;17-22.
55. Orie N.N., Zidek W.M., Tepel M. Tyrosine and calcium/calmodulin kinases are common signaling components in the generation of reactive oxygen species in human lymphocytes. Life Sci. 65:1999;2135-2142.
56. Kabelitz D., Janssen O. Antigen-induced death of T-Lymphocytes. Front. Biosci. 2:1997;d61-d77.
57. Perandones C.E., Illera V.A., Peckham D., Stunz L.L., Ashman R.F. Regulation of apoptosis in vitro in mature murine spleen T cells. J. Immunol. 151:1993;3521-3529.
58. Salmon M., Pilling D., Borthwick N.J., Viner N., Janossy G., Bacon P.A., Akbar A.N. The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis. Eur. J. Immunol. 24:1994;892-899.
59. Jones L.A., Chin L.T., Longo D.L., Kruisbeek A.M. Peripheral clonal elimination of functional T cells. Science. 250:1990;1726-1729.
60. Kawabe Y., Ochi A. Programmed cell death and extrathymic reduction of Vbeta8+ CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B [see comments]. Nature. 349:1991;245-258.
61. Yuan J. Transducing signals of life and death. Curr. Opin. Cell Biol. 9:1997;247-251.
62. Klas C., Debatin K.M., Jonker R.R., Krammer P.H. Activation interferes with the APO-1 pathway in mature human T cells. Int. Immunol. 5:1993;625-630.
63. Alderson M.R., Tough T.W., Braddy S., Davis-Smith T., Roux E., Schooley K., Miller R.E., Lynch D.H. Regulation of apoptosis and T cell activation by Fas-specific mAb. Int. Immunol. 6:1994;1799-1806.
64. Vignaux F., Vivier E., Malissen B., Depraetere V., Nagata S., Golstein P. TCR/CD3 coupling to Fas-based cytotoxicity. J. Exp. Med. 181:1995;781-786.
65. Smith C.A., Williams G.T., Kingston R., Jenkinson E.J., Owen J.J. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature. 337:1989;181-184.
66. Jones L.A., Chin L.T., Longo D.L., Kruisbeek A.M. Peripheral clonal elimination of functional T cells. Science. 250:1990;1726-1729.
67. Lenardo M.J. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature. 353:1991;858-861.
68. Rocha B., von Boehmer H. Peripheral selection of the T cell repertoire. Science. 251:1991;1225-1228.
69. Ashwell J.D., Cunningham R.E., Noguchi P.D., Hernandez D. Cell growth cycle block of T cell hybridomas upon activation with antigen. J. Exp. Med. 165:1987;173-194.
70. Mercep M., Bluestone J.A., Noguchi P.D., Ashwell J.D. Inhibition of transformed T cell growth in vitro by monoclonal antibodies directed against distinct activating molecules. J. Immunol. 140:1988;324-335.
71. Takahashi S., Maecker H.T., Levy R. DNA fragmentation and cell death mediated by T cell antigen receptor/CD3 complex on a leukemia T cell line. Eur. J. Immunol. 19:1989;1911-1919.