Effect of cyclosporine, a P-glycoprotein inhibitor, on the pharmacokinetics of cefepime in rat blood and brain - A microdialysis study

Life Sciences

Volumn 69, Issue 2, 2001, Pages 191-199

  Chang, Yuh Lih ^a,b   Chou, Mei Hui ^b   Lin, Ming Fang ^b   Chen, Chieh Fu ^c   Tsai, Tung Hu ^a,c  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

Blood brain barrier; Cefepime; Cyclosporine; On line microdialysis; Pharmacokinetics

Indexed keywords

CEFEPIME; CYCLOSPORIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD; BRAIN; CONTROLLED STUDY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG STRUCTURE; GRAFT REJECTION; MALE; MICRODIALYSIS; NONHUMAN; ORGAN TRANSPLANTATION; RAT;

ANIMALS; AREA UNDER CURVE; BRAIN; CEPHALOSPORINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOSPORINE; DRUG INTERACTIONS; IMMUNOSUPPRESSIVE AGENTS; MALE; MICRODIALYSIS; P-GLYCOPROTEIN; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 0035371045     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01103-1     Document Type: Article

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