Analysis of the signal pathways involved in the regulation of fatty acid synthase gene expression by insulin and somatotropin

Journal of Animal Science

Volumn 79, Issue 5, 2001, Pages 1194-1200

  Yin, D ^a,b   Griffin, M J ^b   Etherton, T D ^b  

^a WADSWORTH CENTER   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Adipose Tissue; Fatty Acids; Insulin; Signal Transduction; Somatotropin; Synthesis

Indexed keywords

BISINDOLYLMALEIMIDE I; FATTY ACID SYNTHASE; GROWTH HORMONE; INDOLE DERIVATIVE; INSULIN; ISOQUINOLINE DERIVATIVE; JAK2 PROTEIN, MOUSE; JANUS KINASE 2; MALEIMIDE DERIVATIVE; MESSENGER RNA; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; ONCOPROTEIN; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; STAUROSPORINE; SULFONAMIDE;

ADIPOCYTE; ANIMAL; ARTICLE; CELL STRAIN 3T3; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

3T3 CELLS; ADIPOCYTES; ANIMALS; FATTY ACID SYNTHETASE COMPLEX; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GROWTH HORMONE; INDOLES; INSULIN; ISOQUINOLINES; JANUS KINASE 2; MALEIMIDES; MICE; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAUROSPORINE; SULFONAMIDES;

EID: 0035348652     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/2001.7951194x     Document Type: Article

References (38)

1. Agius, L., and M. Peak. 1991. Interactions of okadaic acid with insulin action in hepatocytes: Role of protein phosphatases in insulin action. Biochim. Biophys. Acta 1095:243-248.
2. Argetsinger, L. S., and C. Carter-Su. 1996. Mechanism of signaling by growth hormone receptor. Physiol. Rev. 76:1089-1107.
3. Bennett, M. K., J. M. Lopez, H. B. Sanchez, and T. F. Osborne. 1995. Sterol regulation of fatty acid synthase promoter-coordinate feedback regulation of two major lipid pathways. J. Biol. Chem. 270:25578-25583.
4. Billestrup, N., P. Bouchelouche, G. Allevato, M. Ilondo, and J. H. Nielsen. 1995. Growth hormone receptor C-terminal domains required for growth hormone-induced intracellular free Ca2+ oscillations and gene transcription. Proc. Natl. Acad. Sci. USA 92:2725-2729.
5. Boguslawski, G., L. V. Hale, X. P.Yu, R. R. Miles, J. E. Onyia, R. F. Santerre, and S. Chandrasekhar. 2000. Activation of osteocalcin transcription involves interaction of protein kinase A- and protein kinase C-dependent pathways. J. Biol. Chem. 275:999-1006.
6. Borland, C. A., M. C. Barber, M. T. Travers, and R. G. Vernon. 1994. Growth hormone inhibition of lipogenesis in sheep adipose tissue: Requirement for gene transcription and polyamines. J. Endocrinol. 142:235-243.
7. Cengel, K. A., and G. G. Freund. 1999. JAK1-dependent phosphorylation of insulin receptor substrate-1 (IRS-1) is inhibited by IRS-1 serine phosphorylation. J. Biol. Chem. 274:27969-27974.
8. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
9. Cohen, P. 1993. Dissection of the protein phosphorylation cascades involved in insulin and growth factor action. Biochem. Soc. Trans. 21:555-567.
10. Crespo, P., N. Xu, J. L. Daniotti, J. Troppmair, U. R. Rapp, and J. S. Gutkind. 1994. Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway. J. Biol. Chem. 269:21103-21109.
11. Djian, P., M. Phillips, and H. Green. 1985. The activation of specific gene transcription in the adipose conversion of 3T3 cells. J. Cell. Physiol. 124:554-556.
12. Doglio, A., C. Dani, P. Grimaldi, and G. Ailhaud. 1989. Growth hormone stimulates c-fos gene expression by means of protein kinase C without increasing inositol lipid turnover. Proc. Natl. Acad. Sci. USA 86:1148-1152.
13. Donkin, S. S., P.Y. Chiu, D. Yin, I. Louveau, B. S. Swencki, J. Vockroth, C. M. Evock-Clover, J. L. Peters, and T. D. Etherton. 1996a. Porcine somatotrophin differentially down-regulates expression of the GLUT4 and fatty acid synthase genes in pig adipose tissue. J. Nutr. 126:2568-2577.
14. Donkin, S. S., A. D. McNall, B. S. Swencki, J. L. Peters, and T. D. Etherton. 1996b. The growth hormone-dependent decrease in hepatic fatty acid synthase mRNA is the result of a decrease in gene transcription. J. Mol. Endocrinol. 16:151-158.
15. Etherton, T. D., and D. E. Bauman. 1998. The biology of somatotropin in growth and lactation of domestic animals. Physiol. Rev. 78:745-761.
16. Hillgartner, F. B., L. M. Salati, and A. G. Goodridge. 1995. Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis. Physiol. Rev. 75:47-76.
17. Hunter, T., and M. Karin. 1992. The regulation of transcription by phosphorylation. Cell 70:375-387.
18. Jacob, K. K., and F. M. Stanley. 1994. The insulin and cAMP response elements of the prolactin gene are overlapping sequences. J. Biol. Chem. 269:25515-25520.
19. Kim, J. B., P. Sarraf, M. Wright, K. M. Yao, E. Mueller, G. Solanes, B. B. Lowell, and B.M. Spiegelman. 1998. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J. Clin. Investig. 101:1-9.
20. Klemm, D. J., W. J. Roesler, T. Boras, L. A. Colton, K. Felder, and J. E. Reusch. 1998. Insulin stimulates cAMP-response element binding protein activity in HepG2 and 3T3-L1 cell lines. J. Biol. Chem. 273:917-923.
21. Lazar, D. F., R. J. Wiese, M. J. Brady, C. C. Mastick, S. B. Waters, K. Yamauchi, J. E. Pessin, P. Cuatrecasas, and A. R. Saltiel. 1995. Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J. Biol. Chem. 270:20801-20807.
22. Magri, K. A., M. Adamo, D. Leroith, and T. D. Etherton. 1990. The inhibition of insulin action and glucose metabolism by porcine growth hormone in porcine adipocytes is not the result of any decrease in insulin binding or insulin receptor kinase activity. Biochem. J. 266:107-113.
23. O'Brien, R. M., and D. K. Granner. 1996. Regulation of gene expression by insulin. Physiol. Rev. 76:1109-1161.
24. O'Brien, R. M., E. L. Noisin, and D. K. Granner. 1994. Comparison of the effects of insulin and okadaic acid on phosphoenolpyruvate carboxykinase gene expression. Biochem. J. 303:737-742.
25. Paulauskis, J. D., and H. S. Sul. 1988. Cloning and expression of mouse fatty acid synthase and other specific mRNAs. Developmental and hormonal regulation in 3T3-L1 cells. J. Biol. Chem. 263:7049-7054.
26. Paulauskis, J. D., and H. S. Sul. 1989. Hormonal regulation of mouse fatty acid synthase gene transcription in liver. J. Biol. Chem. 264:574-577.
27. Rangan, V. S., B. Oskouian, and S. Smith. 1996. Identification of an inverted CCAAT box motif in the fatty-acid synthase gene as an essential element for modification of transcriptional regulation by cAMP. J. Biol. Chem. 271:2307-2312.
28. Ridderstrale, M., and H. Tornqvist. 1996. Effects of tyrosine kinase inhibitors on tyrosine phosphorylations and the insulin-like effects in response to human growth hormone in isolated rat adipocytes. Endocrinology 137:4650-4656.
29. Stumpo, D. J., D. M. Haupt, and P. J. Blackshear. 1994. Protein kinase C isozyme distribution and down-regulation in relation to insulin-stimulated c-fos induction. J. Biol. Chem. 269:21184-21190.
30. Tamaoki T., H. Nomoto, I. Takahashi, Y. Kato, M. Morimoto, and F. Tomita. 1986. Staurosporine, a potent inhibitor of phospholipid/ Ca++dependent protein kinase. Biochem. Biophys. Res. Commun. 135:397-402.
31. Valverde, A. M., M. Lorenzo, P. Navarro, C. Mur, and M. Benito. 2000. Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes in an Akt-independent and protein kinase C zeta-dependent manner. FEBS Lett. 472:153-158.
32. Vernon, R. G. 1996. GH inhibition of lipogenesis and stimulation of lipolysis in sheep adipose tissue: involvement of protein serine phosphorylation and dephosphorylation and phospholipase C. J. Endocrinol. 150:129-140.
33. Vernon, R. G. 2000. Adipocyte studies: Systems for investigating effects of growth hormone and other chronically acting hormones. Biochem. Soc. Trans. 28:126-131.
34. Walton, P. E., and T. D. Etherton. 1986. Stimulation of lipogenesis by insulin in swine adipose tissue: Antagonism by porcine growth hormone. J. Anim. Sci. 62:1584-1595.
35. Walton, P. E., T. D. Etherton, and C. M. Evock. 1986. Antagonism of insulin action in cultured pig adipose tissue by pituitary and recombinant porcine growth hormone: potentiation by hydrocortisone. Endocrinology 118:2577-2581.
36. White, M. F. 1997. The insulin signalling system and the IRS proteins. Diabetologia 40 (Suppl. 2): S2-S17.
37. Wilson, L. A., S. E. Mills, E. Finley, E. Kilgour, P. J. Buttery, and R. G. Vernon. 1996. Effect of lactation on insulin signal transduction in sheep adipose tissue and skeletal muscle. J. Endocrinol. 151:469-480.
38. Yin, D., S. D. Clarke, J. L. Peters, and T. D. Etherton. 1998. Somatotropin-dependent decrease in fatty acid synthase mRNA abundance in 3T3-F442A adipocytes is the result of a decrease in both gene transcription and mRNA stability. Biochem. J. 331:815-820.