A new BACE is for therapy of Alzheimer's disease

Trends in Cell Biology

Volumn 11, Issue 5, 2001, Pages 192-

  Kahana, Jason ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BETA SECRETASE; BETA SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1; BETA SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 2; ENZYME; GAMMA SECRETASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; AMYLOIDOSIS; BRAIN TISSUE; CELL CULTURE; CELL ISOLATION; DISEASE COURSE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; GENE DELETION; NERVE CELL CULTURE; NERVE INJURY; NERVOUS TISSUE; NONHUMAN; NOTE; PLAQUE FORMING CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL DETECTION; TISSUE DISTRIBUTION;

EID: 0035341591     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(01)01984-5     Document Type: Short Survey

References (2)

1. Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation
2. BACE1 is the major beta-secretase for generation of A β peptides by neurons