Heat effects of DNA repair after ionising radiation: Hyperthermia commonly increases the number of non-repaired double-strand breaks and structural rearrangements

Nucleic Acids Research

Volumn 29, Issue 9, 2001, Pages 1960-1966

  El Awady, R A ^a,b   Dikomey, E ^a   Dahm Daphi, J ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; ENZYME; DEOXYRIBONUCLEASES, TYPE II SITE SPECIFIC; DNA; ENDODEOXYRIBONUCLEASE NOTI; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE;

ARTICLE; CELL CYCLE G0 PHASE; CELL KILLING; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; DNA STRUCTURE; EXPERIMENT; FIBROBLAST; GEL ELECTROPHORESIS; GENOME; HEAT; HUMAN; HUMAN CELL; HYBRIDIZATION; HYPERTHERMIA; IONIZING RADIATION; LETHALITY; MALE; PRIORITY JOURNAL; PROBABILITY; RESTRICTION FRAGMENT; SCORING SYSTEM; SOUTHERN BLOTTING; TEMPERATURE; TIME; X CHROMOSOME; X IRRADIATION; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CHROMOSOME BREAKAGE; DNA DAMAGE; GENETIC RECOMBINATION; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE;

CELL SURVIVAL; CELLS, CULTURED; CHROMOSOME BREAKAGE; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; HEAT; HUMAN; MALE; RADIATION TOLERANCE; RECOMBINATION, GENETIC; SUPPORT, NON-U.S. GOV'T;

EID: 0035339612     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.9.1960     Document Type: Article

References (54)

1. Dahm-Daphi, J. and Dikomey, E. (1996) Rejoining of DNA double-strand breaks in X-irradiated CHO cells studied by constant-and graded-field gel electrophoresis. Int. J. Radiat. Biol., 69, 615-621.
2. Dikomey, E., Dahm-Daphi, J., Brammer, I., Martensen, R. and Kaina, B. (1998) Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines. Int. J. Radiat. Biol., 73, 269-278.
3. Dikomey, E., Brammer, I., Johansen, J., Bentzen, S.M. and Overgaard, J. (2000) Relationship between DNA double-strand breaks, cell killing and fibrosis studied in confluent skin fibroblasts derived from breast cancer patients. Int. J. Radiat. Oncol. Biol. Phys., 46, 481-490.
4. Dahm-Daphi, J., Dikomey, E., Pyttlik, C. and Jeggo, P. (1993) Reparable and non-reparable DNA strand breaks induced by X-irradiation in CHO K1 cells and the radiosensitive mutants xrs1 and xrs5. Int. J. Radiat. Biol., 64, 19-26.
5. Kasten, U., Borgmann, K., Burgmann, P., Li, G. and Dikomey, E. (1999) Overexpression of human Ku70/Ku80 in rat cells resulting in reduced dsb repair capacity with appropriate increase in cell radiosensitivity but with no effect on cell recovery. Radiat. Res., 151, 532-539.
6. Dahm-Daphi, J., Dikomey, E. and Pyttlik, C. (1994) Relationship between non-reparable strand breaks and cell survival studied in CHO, CHO K1 and the radiosensitive mutants xrs1 and xrs5. Int. J. Radiat. Biol., 65, 657-663.
7. Giaccia, A.J., Schwartz, J., Shieh, J. and Brown, J.M. (1992) The use of asymmetric field inversion gel electrophoresis to predict tumor cell radiosensitivity. Radiother. Oncol., 24, 231-238.
8. Nunez, M.I., McMillan,T.J., Valenzuela, M.T., Ruiz de Almodovar, J.M. and Pedraza, V. (1996) Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells. Radiother. Oncol., 39, 155-165.
9. Ritter, M.A., Cleaver, J.E. and Tobias, C.A. (1977) High-LET radiations induce a large proportion of non-rejoining DNA breaks. Nature, 266, 653-655.
10. Rydberg, B., Löbrich, M. and Cooper, P.K. (1994) DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. I. Pulsed-field gel electrophoresis method. Radiat. Res., 139, 133-141.
11. Iliakis, G., Seaner, R. and Okayasu, R. (1990) Effects of hyperthermia on the repair of radiation-induced DNA single-and double-strand breaks in DNA double-strand break repair-deficient and repair-proficient cell lines. Int. J. Hyperthermia, 6, 813-833.
12. Nevaldine, B., Longo, J.A. and Hahn,P.J. (1994) Hyperthermia inhibits the repair of DNA double-strand breaks induced by ionizing radiation as determined by pulsed-field gel electrophoresis. Int. J. Hyperthermia, 10, 381-388.
13. Dikomey, E. and Jung, H. (1995) Correlation between thermal radiosensitization and slowly-rejoining DNA strand breaks in CHO cells. Int. J. Radiat. Biol., 68, 227-233.
14. Dahm-Daphi, J. Brammer, I. and Dikomey, E. (1997) Heat effects on the repair of DNA double-strand breaks in CHO cells. Int. J. Radiat. Biol., 72, 171-179.
15. Kampinga, H.H., Hiemstra, Y.S., Konings, A.W.T. and Dikomey, E. (1997) Correlation between slowly repairable double-strand breaks and thermal radiosensitization in the human HeLa S3 cell line. Int. J. Radiat. Biol., 72, 293-301.
16. Overgaard, J., Gonzalez Gonzalez, D., Hulshof, M.C.C.H., Arcangeli, G., Dahl, O., Mella, O. and Bentzen, S.M. (1996) Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic malignant melanoma. A multicentre randomized trial by the European Society for Hyperthermic Oncology. Int. J. Hyperthermia, 12, 3-20.
17. van der Zee, J., Gonzalez-Gonzalez, D., van Rhoon, G.C., van Dijk, J.D., van Putten, W.L. and Hart, A.A. (2000) Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours. A prospective, randomized, multicentre trial. Dutch Deep Hyperthermia Group. Lancet, 355, 1119-1125.
18. Dewey, W.C., Sapareto, S.A. and Betten, D.A. (1978) Hyperthermic radiosensitization of synchronous Chinese hamster cells: relationship between lethality and chromosomal aberrations. Radiat. Res., 76, 48-59.
19. Löbrich, M., Rydberg, B. and Cooper, P.K. (1994) DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. II. Probing individual NotI fragments by hybridization. Radiat Res., 139, 142-151.
20. Löbrich, M., Rydberg, B. and Cooper, P.K. (1995) Repair of X-ray-induced DNA double-strand breaks in specific NotI restriction fragments in human fibroblasts: joining of correct and incorrect ends. Proc. Natl Acad. Sci. USA, 92, 12050-12054.
21. Löbrich, M., Cooper, P.K. and Rydberg, B. (1998) Joining of correct and incorrect DNA ends at double-strand breaks produced by high-linear energy transfer radiation in human fibroblasts. Radiat. Res., 150, 619-626.
22. Rothkamm, K. and Löbrich, M. (1999) Misrejoiningof DNA double-strand breaks in primary and transformed human and rodent cells: a comparison between the HPRT region and other genomic locations. Mutat. Res., 433, 193-205.
23. Fouladi, B., Waldren, C.A., Rydberg, B. and Cooper, P.K. (2000) Comparison of repair of DNA double-strand breaks in identical sequences in primary human fibroblast and immortal hamster-human hybrid cells harbouring a single copy of human chromosome 11. Radiat. Res., 153, 795-804.
24. Hendrickson, E.A. (1997) Insights from model systems. Cell cycle regulation of mammalian DNA double-strand break repair. Am. J. Hum. Genet., 61, 795-800.
25. Lin, Y., Lukacsovich, T. and Waldman, A.S. (1999) Multiple pathways for repair of DNA double-strand breaks in mammalian chromosoms. Mol. Cell. Biol., 19, 8353-8360.
26. Pfeiffer, P., Goedecke, W. and Obe, G. (2000) Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations. Mutagenesis, 15, 289-302.
27. Morris, T. and Thacker, J. (1993) Formation of large deletions by illegitimate recombination in the HPRT gene of primary human fibroblasts. Proc. Natl Acad. Sci. USA, 90, 1392-1396.
28. Kronenberg, A., Gauny, S., Criddle, K., Vannais, D., Ueno, A., Kraemer, S. and Waldren, S.A. (1995) Heavy ion mutagenesis: linear energy transfer effects and genetic linkage. Radiat. Environ. Biophys., 34, 73-78.
29. Haber, J.E. and Leung, W.Y. (1996) Lack of chomosome territoriality in yeast: promiscous rejoining of broken chromosome ends. Proc. Natl Acad. Sci. USA, 93, 13949-13954.
30. Haber, J.E. (1999) DNA recombination: the replication connection. Trends Biochem. Sci., 24, 271-275.
31. Brenneman, M.A., Weiss, A.E., Nickoloff, J.A. and Chen, D.J. (2000) XRCC3 is required for efficient repair of chromosome breaks by homologous recombination. Mutat. Res., 459, 89-97.
32. Richardson, C. and Jasin, M. (2000) Frequent chromosomal translocations induced by DNA double-strand breaks. Nature, 405, 697-700.
33. Moynahan, M.E. and Jasin, M. (1997) Loss of heterozygosity induced by a chromosomal doube-strand break. Proc. Natl Acad. Sci. USA, 94, 8988-8993.
34. Rothstein, R., Michel, B. and Gangloff, S. (2000) Replication fork pausing and recombination or "gimme a break". Genes Dev., 14, 1-10.
35. Oberle, I., Camerino, G., Kloepfer, C., Moisan, J.P., Grzeschik, K.H., Hellkuhl, B., Hors-Cayla, M.C., Van Cong, N., Weil, D. and Mandel, J.L. (1986) Characterization of a set of X-linked sequences and a panel of somatic cell hybrids useful for the regional mapping of the human X chromosome. Hum. Genet., 72, 43-49.
36. Lippert, M.J., Albertini, R.J. and Nicklas, J.A. (1995) Physical mapping of the human hprt chromosomal region (Xq26). Mutat. Res., 326, 39-49.
37. Sak, A. and Stuschke, M. (1998) Repair of ionizing radiation induced DNA double-strand breaks (dsb) at the c-myc locus in comparison to the overall genome. Int. J. Radiat. Biol., 73, 35-43.
38. Kühne, M., Rothkamm, K. and Löbrich, M. (2000) No dose-dependence of DNA double-strand break misrejoining following α-particle irradiation. Int. J. Radiat. Biol., 76, 891-900.
39. Corry, P.M., Robinson, S. and Getz, S. (1977) Hyperthermic effects on DNA repair mechanisms. Radiology, 123, 475-482.
40. Mills, M.D. and Meyn, R.E. (1981) Effects of hyperthermia on repair of radiation-induced DNA strand breaks. Radiat. Res., 87, 314-328.
41. Wong, R.S.L., Dynlacht, J.R., Cedervall, B. and Dewey, W.C. (1995) Analysis by pulsed-field gel electrophoresis of DNA double-strand breaks induced by heat and/or x-irradiation in bulk and replicating DNA of CHO cells. Int. J. Radiat. Biol., 68, 141-152.
42. Jeggo, P.A., Taccioli, G.E. and Jackson, S.P. (1995) Menage a'trois: double strand break repair, V(D)J recombination and DNA-PK. Bioessays, 17, 949-957.
43. Pang, D., Yoo, S., Dynan, W.S., Jung, M. and Dritschilo, A. (1997) Ku proteins join DNA fragments as shown by atomic force microscopy. Cancer Res., 57, 1412-1415.
44. Burgman, P., Ouyang, H., Peterson, S., Chen, D.J. and Li, G.C. (1997) Heat inactivation of Ku autoantigen: possible role in hyperthermic radiosensitization. Cancer Res., 57, 2847-2850.
45. Woudstra, E.C., Konings, A.W.T., Jeggo, P.A. and Kampinga, H.H. (1999) Role of DNA-PK subunits in radiosensitization by hyperthermia. Radiat. Res., 152, 214-218.
46. Kojis, T.L., Gatti, R.A. and Sparkes, R.S. (1989) The cytogenetics of ataxia telangiectasia. Cancer Genet. Cytogenet., 56, 143-156.
47. Antoccia, A., Stumm, M, Saar, K., Ricordy, R., Maraschio, P. and Tanzarella, C. (1999) Impaired p53-mediated DNA damage response, cell-cycle disturbance and chromosome aberrations in Nijmegen breakage syndrome lymphoblastoid cell lines. Int. J. Radiat. Biol., 75, 583-591.
48. Kemp, L.M. and Jeggo, P.A. (1986) Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line. Mutat. Res., 166, 255-263.
49. Difilippantonio, M.J., Zhu, J., Chen, H.T., Meffre, E., Nussenzweig, M.C., Max, E.E., Roed, T. and Nussenzweig, A. (2000) DNA repair protein Ku80 suppress chromosomal aberrations and malignant transformation. Nature, 404, 510-514.
50. Chen, C. and Kolodner, R.D. (1999) Gross chromosomal rearrangements in S. cerevisiae replication and recombination defective mutants. Nat. Genet., 23, 81-85.
51. Borgmann, K. and Dikomey, E. (1997) Relationship between PCC-fragments and cell killing studied in X-irradiated CHO, CHO K1 cells and two radiosensitive mutants xrsl and xrs5. Int. J. Radiat. Biol., 72, 667-674.
52. Sak, A., Stuschke, M., Stapper, N. and Streffer, C. (1996) Induction of DNA double-strand breaks by ionizing radiation at the c-myc locus compared with the whole genome: a study using pulsed-field gel electrophoresis and gene probing. Int. J. Radiat. Biol., 69, 679-685.
53. Dahm-Daphi, J. and Dikomey, E. (1995) Separation of DNA fragments induced by ionizing irradiation using a graded-field gel electrophoresis. Int. J. Radiat. Biol., 67, 161-168.
54. Forrester, H.B., Yeh, R.-F. and Dewey, W.C. (1999) A dose response for radiation-induced intrachromosomal DNA rearrangements detected by inverse polymerase chain reaction. Radiat. Res., 152, 232-238.