Mutations in the Nijmegen Breakage Syndrome gene (NBS1) in childhood acute lymphoblastic leukemia (ALL)

Cancer Research

Volumn 61, Issue 9, 2001, Pages 3570-3572

  Varon, Raymonda ^a   Reis, André ^a,b   Henze, Günter ^a   Einsiedel, Hagen Graf V ^a   Sperling, Karl ^a   Seeger, Karlheinz ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; NIBRIN; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CHILD; CHILDHOOD LEUKEMIA; CHROMOSOME 8Q; CHROMOSOME FRAGILITY; CLINICAL ARTICLE; CONTROLLED STUDY; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; LYMPH NODE; NIJMEGEN BREAKAGE SYNDROME; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

ADOLESCENT; CELL CYCLE PROTEINS; CHILD; GENES, TUMOR SUPPRESSOR; GERM-LINE MUTATION; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; NUCLEAR PROTEINS; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY;

EID: 0035328489     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

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3. Regulated genomic instability and neoplasia in the lymphoid lineage
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6. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
7. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
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9. The FHA domain: A putative nuclear signalling domain found in protein kinases and transcription factors
10. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins
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15. Link between breast cancer and ATM gene is strong
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17. Clinical ascertainment of Nijmegen breakage syndrome (NBS) and prevalence of the major mutation, 657de15, in three Slavic populations
18. Diversity of ATM mutations detected in patients with ataxia-telangiectasia
19. Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer
20. Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene