Myosin motors: Missing structures and hidden springs

Current Opinion in Structural Biology

Volumn 11, Issue 2, 2001, Pages 182-194

  Houdusse, Anne ^a   Sweeney, H Lee ^b  

^a INSTITUT CURIE   (France)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYOSIN;

ACTIN MYOSIN INTERACTION; BINDING AFFINITY; BINDING KINETICS; FORCE; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; REVIEW;

ACTINS; ACTOMYOSIN; ADENOSINE TRIPHOSPHATASES; ANIMALS; CALMODULIN-BINDING PROTEINS; MODELS, MOLECULAR; MYOSIN TYPE V; MYOSINS; NERVE TISSUE PROTEINS; PROTEIN CONFORMATION;

EID: 0035312384     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(00)00188-3     Document Type: Review

References (77)

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4. Myosin V is a processive actin-based motor
5. Myosin-V stepping kinetics: A molecular model for processivity
6. Thekinetic mechanism of myosin V
7. Direct observation of processive movement by individual myosin V molecules
8. Three-dimensional structure of myosin subfragment-1: A molecular motor
9. X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-
10. Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: Visualization of the pre-power stroke state
11. Three conformational states of scallop myosin S1
12. X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain
13. Atomic structure of scallop myosin subfragment S1 complexed with MgADP: A novel conformation of the myosin head
14. Structure of the actin-myosin complex and its implications for muscle contraction
15. Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1
16. A 35-Å movement of smooth muscle myosin on ADP release
17. A 32 degree tail swing in brush border myosin I on ADP release
18. Structural invariance of constitutively active and inactive mutants of acanthamoeba myosin IC bound to F-actin in the rigor and ADP-bound states
19. Myosin VI is an actin-based motor that moves backwards
20. Evidence for cleft closure in actomyosin upon ADP release
21. Structural mechanism of muscle contraction
22. Lever arm model of force generation by actin-myosin-ATP
23. Protein-protein interactions in the rigor actomyosin complex
24. Normal modes as refinement parameters for the F-actin model
25. The way things move: Looking under the hood of molecular motors
26. The neck region of the myosin motor domain acts as a lever arm to generate movement
27. The light chain binding domain of expressed smooth muscle heavy meromyosin acts as a mechanical lever
28. The role of three-state docking of myosin S1 with actin in force generation
29. Mechanism of adenosine triphosphate hydrolysis by actomyosin
30. Swing of the lever arm of a myosin motor at the isomerization and phosphate-release steps
31. Reaction of 5,5′-dithiobis(2-nitrobenzoic acid) with myosin subfragment one: Evidence for formation of a single protein disulfide with trapping of metal nucleotide at the active site
32. Probing the conformational states of the SH1-SH2 helix in myosin: A cross-linking approach
33. Actin and temperature effects on the cross-linking of the SH1-SH2 helix in myosin subfragment 1
34. Fluorescence polarization from isomers of tetramethylrhodamine at SH-1 in rabbit psoas muscle fibers
35. The mechanism of force generation in myosin. A disorder-to-order transition, coupled to internal structural changes
36. X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain
37. Kinetic studies on the association and dissociation of myosin subfragment-1 and actin
38. Observation of transient disorder during myosin subfragment-1 binding to actin by stopped-flow fluorescence and millisecond time resolution electron cryomicroscopy: Evidence that the start of the crossbridge power stroke in muscle has variable geometry
39. Exchange between inorganic phosphate and adenosine 5′-triphosphate in the medium by actomyosin subfragment 1
40. Indirect coupling of phosphate release to de novo tension generation during muscle contraction
41. Kinetic and spectroscopic evidence for three actomyosin: ADP states in smooth muscle
42. Single molecule analysis of the actomyosin motor
43. A high resolution 3-D reconstruction of decorated-actin from filter-cryo-EM reveals the structure of the strong binding state
44. Modulation of actin affinity and actomyosin adenosine triphosphatase by charge changes in the myosin motor domain
45. Disturbed communication between actin- and nucleotide-binding sites in a myosin II with truncated 50/20 kDa junction
46. The sequence of the myosin 50-20K loop affects Myosin's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity
47. Two conserved lysines at the 5020 kDa junction of myosin are necessary for triggering actin-activation
48. Functional characterization of the secondary actin binding site of myosin II
49. Cold-sensitive mutations of Dictyostelium myosin heavy chain highlight functional domains of the myosin motor
50. Deletion of the myopathy loop of Dictyostelium myosin II and its impact on motor functions
51. A conserved negatively charged amino acid modulates function in human nonmuscle myosin IIA
52. Intrinsic tryptophan fluorescence identifies specific conformational changes at the actomyosin interface upon actin binding and ADP release
53. Analysis of the regulatory phosphorylation site in Acanthamoeba myosin IC by using site-directed mutagenesis
54. TEDS rule: A molecular rationale for differential regulation of myosins by phosphorylation of the heavy chain head
55. Nonspecific weak actomyosin interactions: Relocation of charged residues in subdomain 1 of actin does not alter actomyosin function
56. Conformation of the myosin motor during force generation in skeletal muscle
57. Is the lever arm of myosin a molecular elastic element?
58. Functional consequences of mutations in the smooth muscle myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathy
59. Flexibility within myosin heads revealed by negative stain and single particle analysis
60. Two heads of myosin are better than one for generating force and motion
61. A single myosin head moves along an actin filament with regular steps of 5.3 nanometres
62. Simultaneous observation of individual ATPase and mechanical events by a single myosin molecule during interaction with actin
63. Rate of phosphate release after photoliberation of adenosine 5′-triphosphate in slow and fast skeletal muscle fibers
64. A FRET-based sensor reveals large ATP hydrolysis-induced conformational changes and three distinct states of the molecular motor myosin
65. Tomographic 3D reconstruction of quick-frozen, Ca2+-activated contracting insect flight muscle
66. Proposed mechanism of force generation in striated muscle
67. Wag the tail: Structural dynamics of actomyosin
68. Reversal of the cross-bridge force-generating transition by photogeneration of phosphate in rabbit psoas muscle fibres
69. Phosphorylation regulates the ADP-induced rotation of the light chain domain of smooth muscle myosin
70. Kinetic characterization of brush border myosin-I ATPase
71. The motor protein myosin-I produces its working stroke in two steps
72. Kinetic analyses of a truncated mammalian myosin I suggest a novel isomerization event preceding nucleotide binding
73. Two-headed binding of a processive myosin to F-actin
74. A model of Ca(2+)-free calmodulin binding to unconventional myosins reveals how calmodulin acts as a regulatory switch
75. Myosin structure: Does the tail wag the dog?