Immunization against Intestinal Bacterial Endotoxin Prevents Alcoholic Fatty Liver in Rats

Journal of Veterinary Medical Science

Volumn 63, Issue 3, 2001, Pages 275-280

  Nishimura, Gendo ^a   Nakahara, Keiko ^a   Misawa, Naoaki ^a   Muranaka, Miki ^a   Uchida, Kazuyuki ^a   Kuroda, Haruto ^a   Murakami, Noboru ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

Alcohol; Endotoxin; Fatty liver

Indexed keywords

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BACTERIAL ANTIGEN; BACTERIUM ANTIBODY; CREATINE KINASE; CYTOKINE; LIPOPOLYSACCHARIDE; TRIACYLGLYCEROL;

ALCOHOLIC FATTY LIVER; ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; DRINKING BEHAVIOR; ENZYMOLOGY; FAT INTAKE; FEMALE; IMMUNIZATION; IMMUNOLOGY; RAT; WISTAR RAT;

ALANINE TRANSAMINASE; ALCOHOL DRINKING; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; ASPARTATE AMINOTRANSFERASES; CREATINE KINASE; CYTOKINES; DIETARY FATS; FATTY LIVER, ALCOHOLIC; FEMALE; IMMUNIZATION; LIPOPOLYSACCHARIDES; RATS; RATS, WISTAR; TRIGLYCERIDES;

EID: 0035286841     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.63.275     Document Type: Article

References (29)

1. Adachi, Y., Bradford, B. U., Gao, W., Bojes, H. K. and Thurman, R. G. 1994. Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology 20: 453-460.
2. Adachi, Y., Moore, L. E., Bradford, B. U., Gao, W. and Thurman, R. G. 1995. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 108: 218-224.
3. Arai, M. 1986. Effect of ethanol on the intestinal uptake of endotoxin (Abstract). Nippon Shokakibyo Gakkai Zasshi 83: 1060.
4. Bjarnason, I., Ward, K. and Peters, T. J. 1984. The leaky gut of alcoholism: possible route of entry for toxic compounds. Lancet 1: 179-182.
5. Bode, C. H., Kugler, V. and Bode, J. C. 1987. Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J. Hepatol. 4: 8-14.
6. Crabb, D.W. 1999. Pathogenesis of alcoholic liver disease: new mechanisms of injury. Keio J. Med. 48: 184-188.
7. Decker, T., Lohmann-Matthes, M. L., Karck, U., Peters, T. and Decker, K. 1989. Comparative study of cytotoxicity, tumor necrosis factor, and prostaglandin release after stimulation of rat Kupffer cells, murine Kupffer cells, and murine inflammatory liver macrophages. J. Leukoc. Biol. 45: 139-146.
8. Earnest, D. L., Abril, E. R., Jolley, C. S. and Martinez, F. 1993. Ethanol and diet-induced alterations in Kupffer cell function. Alcohol Alcohol. 28: 73-83.
9. Enomoto, N., Ikejima, K., Bradford, B. U., Rivera, C. A., Kono, H., Brenner, D. A. and Thurmann, R. G. 1998. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastoroenterology 115: 443-451.
10. Enomoto, N., Ikejima, K., Bradford, B. U., Rivera, C. A., Kono, H., Goto, M., Yamashina, S., Schmmer, P., Kitamura, T., Oide, H., Takei, Y., Hirose, M., Shimizu, H., Miyazaki, A., Brenner, D. A., Sato N. and Thurmann, R. G. 2000. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. J. Gastoroenterol. Hepatol. (Suppl.) D20-25.
11. French, S. W. 1993. Nutrition in the pathogenesis of alcoholic liver disease. Alcohol Alcohol. 28: 97-109.
12. Hill, D. B., Marsano, L., Cohen, D., Allen, J., Shedlofsky, S. and McClain, C. J. 1992. Inceased plasma interleukin-6 concentrations in alcoholic hepatitis. J. Lab. Clin. Med. 119: 547-552.
13. Huang, Y. S., Chan, C. Y., Wu, J. C., Pai, C. H., Chao, Y. and Lee, S.D. 1996. Serum levels of interleukin-8 in alcoholic liver disease: relationship with disease stage, biochemical parameters and survival. J. Hepatol. 24: 377-384
14. Iimuro, Y., Ikejima, K., Rose, M. L., Bradford, B. U. and Thurmann, R. G. 1996. Nimodipine, a dihydropyridine-type calcium channel blocker, prevents alcoholic hepatitis due to chronic intragastric ethanol exposure in the rat. Hepatology 24: 391-397.
15. Iimuro, Y., Frankenberg, M.V., Arteel, G. E., Bradford, B. U., Wall, C. A. and Thurman, R. G. 1997. Female rats exhibit greater susceptibility to early alcohol-induced injury than males. Am. J. Physiol. 272: G1186-G1194.
16. Knecht, K. T., Bradford, B. U., Mason, R. P. and Thurman, R. G. 1990. In vivo formation of a free radical metabolite of ethanol. Mol. Pharmacol. 38: 26-30.
17. Martinez, F., Abril, E. R., Earnest, D. L. and Watson, R. R. 1992. Ethanol and cytokine secretion. Alcohol 9: 455-458.
18. McClain, C. J., Cohen, D. A., Dinarello, C. A., Cannon, J. G., Shedlofsky, S. I. and Kaplan, A. M. 1986. Serum interleukin-1 (IL-1) activity in alcoholic hepatitis. Life Sci. 39: 1479-1485.
19. Nanji, A. A., Khettry, U., Sadrzadeh, S. M. and Yamanaka, T. 1993. Severity of liver injury in experimental alcoholic liver disease. Correlation with plasma endotoxin, prostaglandin E2, leukotriene B4, and Thromboxane B2. Am. J. Pathol. 142: 367-373.
20. Nanji, A. A., Khettry, U. and Sadrzadeh, S. M. H. 1994. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver disease. Proc. Soc. Exp. Biol. Med. 205: 243-247.
21. Naveau, S., Giraud, V., Borotto, E., Aubert, A., Capron, F. and Chaput, J. C. 1997. Excess weight risk factor for alcoholic liver disease. Hepatology 25: 108-111.
22. Nelson, S., Bagby, G. J., Bainton, B. G. and Summer, W. R. 1989. The effect of acute and chronic alcoholism on tumor necrosis factor and inflammatory response. J. Infect. Dis. 160: 422-429.
23. Stahnke, L. L., Hill, D. B. and Allen, J. I. 1991. TNFalpha and IL-6 in alcoholic liver disease. pp. 472-475. In: Cells of the Hepatic Sinusoid (Wisse, E., Knook, D. L. and McCusky, R. S. eds), Leiden, The Netherlands: Kupffer Cell Foundation..
24. Tabakoff, B., Hoffman, P. L., Lee, J. M., Saito, T., Willard, B. and Leon-Jones, F. D. 1988. Differences in platelet enzyme activity between alcoholics and nonalcoholics. New Engl. J. Med. 318: 134-139.
25. Thurman, R. G. 1998. Mechanisms of hepatic toxicity II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am. J. Physiol. 275: G605-G611.
26. Tsukamoto, H., Reiderberger, R. D., French, S. W. and Largman, C. 1984. Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am. J. Physiol. 247: R595-R599.
27. Turmann, R. G., Bradford, B. U., Iimuro, Y., Knecht, K. T., Conner, H. D., Adachi, Y., Wall, C., Arteel, G. E., Raleigh, J. A.. Forman, D. T. and Mason, R. P. 1997. Role of Kupffer cells, endotoxin and free radicals in hepatotoxicity due to prolonged alcohol consumption: Studies in female and male rats. J. Nutr. 127: 903S-906S.
28. Wang, P., Kitchens, R. L. and Munford, R. S. 1998. Phosphatidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide. J. Biol. Chem. 273: 24309-24313.
29. Yamada, S., Mochida, S., Ohno, A., Hirata, K., Ogata, I., Ohta, Y. and Fujiwara, K. 1991. Evidence for enhanced secretory function of hepatic macrophages ager long-term ethanol feeding in rats. Liver 11: 220-224.