메뉴 건너뛰기




Volumn 3, Issue 2, 2001, Pages 94-101

Adjuvant chemotherapy for colon cancer

Author keywords

Colon Cancer; FUDR; Leucovorin; Levamisole; Raltitrexed

Indexed keywords

ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; FLUOROURACIL; FOLINIC ACID;

EID: 0035286598     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-001-0007-6     Document Type: Article
Times cited : (11)

References (47)
  • 1
    • 0017317457 scopus 로고
    • Chemoprophylaxis for patients with colorectal cancer: prospective study with five-year follow-up
    • Li MC, Ross ST: Chemoprophylaxis for patients with colorectal cancer: prospective study with five-year follow-up. JAMA 1976, 238:2825–2828. DOI: 10.1001/jama.235.26.2825
    • (1976) JAMA , vol.238 , pp. 2825-2828
    • Li, M.C.1    Ross, S.T.2
  • 3
    • 0021358193 scopus 로고
    • Efficacy of prolonged intermittent therapy with combined 5-fluorouracil and methyl-CCNU following resection for carcinoma of the large bowel: a Veterans Administration Surgical Oncology Group report
    • PID: 6360325
    • Higgins GA Jr, Amadeo JH, McElhinney J, et al.: Efficacy of prolonged intermittent therapy with combined 5-fluorouracil and methyl-CCNU following resection for carcinoma of the large bowel: a Veterans Administration Surgical Oncology Group report. Cancer 1984, 53:1–8. DOI: 10.1002/1097-0142(19840101)53:1<1::AID-CNCR2820530102>3.0.CO;2-L
    • (1984) Cancer , vol.53 , pp. 1-8
    • Higgins, G.A.1    Amadeo, J.H.2    McElhinney, J.3
  • 4
    • 0023887810 scopus 로고
    • Adjuvant therapy of colorectal cancer
    • PID: 3286920, COI: 1:STN:280:DyaL1c3jtVyisA%3D%3D
    • Buyse M, Zeleniuch A, Chalmers T: Adjuvant therapy of colorectal cancer. JAMA 1988, 259:3571–3578. DOI: 10.1001/jama.259.24.3571
    • (1988) JAMA , vol.259 , pp. 3571-3578
    • Buyse, M.1    Zeleniuch, A.2    Chalmers, T.3
  • 5
    • 0023855192 scopus 로고
    • Postoperative adjuvant chemotherapy or BCG for colon cancer: results from NSABP protocol C-01
    • PID: 3276901, COI: 1:STN:280:DyaL1c7hvFSjtw%3D%3D
    • Wolmark N, Fisher B, Rockette H, et al.: Postoperative adjuvant chemotherapy or BCG for colon cancer: results from NSABP protocol C-01. J Natl Cancer Inst 1988, 80:30–36. DOI: 10.1093/jnci/80.1.30
    • (1988) J Natl Cancer Inst , vol.80 , pp. 30-36
    • Wolmark, N.1    Fisher, B.2    Rockette, H.3
  • 6
    • 0003051810 scopus 로고
    • Levamisole therapy in patients with colon cancer
    • Terry W, Rosenberg S, (eds), Elsevier, New York
    • Verhaegen H, DeCree J, DeCock, et al.: Levamisole therapy in patients with colon cancer. In Immunotherapy of Human Cancer. Edited by Terry W, Rosenberg S. New York: Elsevier; 1982:225–229.
    • (1982) Immunotherapy of Human Cancer , pp. 225-229
    • Verhaegen, H.1    DeCree, J.2    DeCock3
  • 7
    • 7144254420 scopus 로고
    • Interim analysis of a trial of levamisole and 5-fluorouracil in metastatic colorectal carcinoma
    • Terry W, Rosenberg S, (eds), Elsevier, New York
    • Borden E, Davis T, Crowley J, et al.: Interim analysis of a trial of levamisole and 5-fluorouracil in metastatic colorectal carcinoma. In Immunotherapy of Human Cancer. Edited by Terry W, Rosenberg S. New York: Elsevier; 1982:231–235.
    • (1982) Immunotherapy of Human Cancer , pp. 231-235
    • Borden, E.1    Davis, T.2    Crowley, J.3
  • 8
    • 0024397951 scopus 로고
    • Surgical adjuvant therapy of large-bowel carcinoma: an evaluation of levamisole and the combination of levamisole and fluorouracil: the North Central Cancer Treatment Group and the Mayo Clinic [see comments]
    • PID: 2778478, COI: 1:STN:280:DyaL1MzotFOluw%3D%3D
    • Laurie JA, Moertel CG, Fleming TR, et al.: Surgical adjuvant therapy of large-bowel carcinoma: an evaluation of levamisole and the combination of levamisole and fluorouracil: the North Central Cancer Treatment Group and the Mayo Clinic [see comments]. J Clin Oncol 1989, 7:1447–1456.
    • (1989) J Clin Oncol , vol.7 , pp. 1447-1456
    • Laurie, J.A.1    Moertel, C.G.2    Fleming, T.R.3
  • 9
    • 0025023997 scopus 로고
    • Adjuvant therapy for colon and rectal cancer: NIH Consensus Development Conference
    • PID: 2144167, COI: 1:STN:280:DyaK3czms1Whsg%3D%3D
    • Metzger U: Adjuvant therapy for colon and rectal cancer: NIH Consensus Development Conference. Eur J Cancer 1990, 26:753–755. DOI: 10.1016/0277-5379(90)90136-H
    • (1990) Eur J Cancer , vol.26 , pp. 753-755
    • Metzger, U.1
  • 10
    • 0028956045 scopus 로고
    • Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: a final report
    • PID: 7847642, COI: 1:STN:280:DyaK2M7ltVejtQ%3D%3D
    • Moertel CG, Fleming TR, Macdonald JS, et al.: Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: a final report. Ann Intern Med 1995, 122:321–326.
    • (1995) Ann Intern Med , vol.122 , pp. 321-326
    • Moertel, C.G.1    Fleming, T.R.2    Macdonald, J.S.3
  • 11
    • 0000539920 scopus 로고    scopus 로고
    • A randomized trial of adjuvant therapy of stage III colon cancer: levamisole and 5-Fluorouracil versus 5-Fluorouracil alone [abstract]
    • Cascinu S, Catalano V, Latini G, et al.: A randomized trial of adjuvant therapy of stage III colon cancer: levamisole and 5-Fluorouracil versus 5-Fluorouracil alone [abstract]. Proc ASCO 1999, 18:923.
    • (1999) Proc ASCO , vol.18 , pp. 923
    • Cascinu, S.1    Catalano, V.2    Latini, G.3
  • 12
    • 0028835122 scopus 로고
    • Intergroup study of fluorouracil plus levamisole as adjuvant therapy for stage II/Dukes’ B2 colon cancer
    • PID: 8523058, COI: 1:CAS:528:DyaK28XmslOmsA%3D%3D
    • Moertel CG, Fleming TR, Macdonald JS, et al.: Intergroup study of fluorouracil plus levamisole as adjuvant therapy for stage II/Dukes’ B2 colon cancer. J Clin Oncol 1995, 13:2936–2943.
    • (1995) J Clin Oncol , vol.13 , pp. 2936-2943
    • Moertel, C.G.1    Fleming, T.R.2    Macdonald, J.S.3
  • 13
    • 0022479537 scopus 로고
    • Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells
    • PID: 2944577, COI: 1:CAS:528:DyaL28XmtFynsLk%3D
    • Keyomarsi K, Moran R: Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells. Cancer Res 1986, 46:5229–5235.
    • (1986) Cancer Res , vol.46 , pp. 5229-5235
    • Keyomarsi, K.1    Moran, R.2
  • 14
    • 0023485117 scopus 로고
    • Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin
    • Rustum Y, Trave F, Zakrzewski S, et al.: Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin. Natl Cancer Inst Monogr 1987, 5:165–170.
    • (1987) Natl Cancer Inst Monogr , vol.5 , pp. 165-170
    • Rustum, Y.1    Trave, F.2    Zakrzewski, S.3
  • 15
    • 0027436244 scopus 로고
    • The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: results from National Surgical Adjuvant Breast and Bowel Project protocol C-03
    • PID: 8410113, COI: 1:STN:280:DyaK2c%2FhsFajtw%3D%3D
    • Wolmark N, Rockette H, Fisher B, et al.: The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: results from National Surgical Adjuvant Breast and Bowel Project protocol C-03. J Clin Oncol 1993, 11:1879–1887.
    • (1993) J Clin Oncol , vol.11 , pp. 1879-1887
    • Wolmark, N.1    Rockette, H.2    Fisher, B.3
  • 16
    • 0029644482 scopus 로고
    • Efficacy of adjuvant fluorouracil and folinic acid in colon cancer [see comments]
    • International Multicentre Pooled Analysis of Colon Cancer Trials (IMPACT) investigators: Efficacy of adjuvant fluorouracil and folinic acid in colon cancer [see comments]. Lancet 1995, 345:939–944. DOI: 10.1016/S0140-6736(95)90696-7
    • (1995) Lancet , vol.345 , pp. 939-944
  • 17
    • 0031022988 scopus 로고    scopus 로고
    • Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer
    • PID: 8996149, COI: 1:CAS:528:DyaK2sXnsV2msg%3D%3D
    • O’Connell MJ, Mailliard JA, Kahn MJ, et al.: Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer. J Clin Oncol 1997, 15:246–250.
    • (1997) J Clin Oncol , vol.15 , pp. 246-250
    • O’Connell, M.J.1    Mailliard, J.A.2    Kahn, M.J.3
  • 18
    • 0032729240 scopus 로고    scopus 로고
    • Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes’ B and C carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project C-04
    • PID: 10550154, COI: 1:CAS:528:DyaK1MXnvVGltLo%3D, The NSABP C-04 compared the efficacy of leucovorin-modulated 5-fluorouracil (5-FU) with that of fluorouracil and levamisole or with a combination of all three drugs given as adjuvant therapy after resection of stage II and III colon cancer. The 5-FU/leucovorin combination had a slight advantage over the combination with levamisole terms of both overall and disease-free survival, but addition of levamisole to this combination did not add any further benefit. This study confirmed the results of earlier trials regarding the efficacy of the 5-FU/leucovorin combination
    • Wolmark N, Rockette H, Mamounas E, et al.: Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes’ B and C carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project C-04. J Clin Oncol 1999, 17:3553–3559. The NSABP C-04 compared the efficacy of leucovorin-modulated 5-fluorouracil (5-FU) with that of fluorouracil and levamisole or with a combination of all three drugs given as adjuvant therapy after resection of stage II and III colon cancer. The 5-FU/leucovorin combination had a slight advantage over the combination with levamisole in terms of both overall and disease-free survival, but addition of levamisole to this combination did not add any further benefit. This study confirmed the results of earlier trials regarding the efficacy of the 5-FU/leucovorin combination.
    • (1999) J Clin Oncol , vol.17 , pp. 3553-3559
    • Wolmark, N.1    Rockette, H.2    Mamounas, E.3
  • 19
    • 0000068297 scopus 로고    scopus 로고
    • Fluorouracil (FU), Leucovorin (LV) and Levamisole (LEV) adjuvant therapy for colon cancer: five year final report of INT-0089
    • Haller D, Catalano P, Macdonald J, et al.: Fluorouracil (FU), Leucovorin (LV) and Levamisole (LEV) adjuvant therapy for colon cancer: five year final report of INT-0089. Proc ASCO 1998, 17:256a(982).
    • (1998) Proc ASCO , vol.17 , pp. 256a
    • Haller, D.1    Catalano, P.2    Macdonald, J.3
  • 20
    • 0020052545 scopus 로고
    • Carcinoma of the colon and rectum: the natural history reviewed in 1,704 patients
    • PID: 7059938, COI: 1:STN:280:DyaL387js1KhsA%3D%3D
    • Eisenberg B, DeCosse J, Harford F, et al.: Carcinoma of the colon and rectum: the natural history reviewed in 1,704 patients. Cancer 1982, 49:1131–1134. DOI: 10.1002/1097-0142(19820315)49:6<1131::AID-CNCR2820490611>3.0.CO;2-T
    • (1982) Cancer , vol.49 , pp. 1131-1134
    • Eisenberg, B.1    DeCosse, J.2    Harford, F.3
  • 21
    • 0013920808 scopus 로고
    • Cancer of the colon, rectum and anus. Review of 1687 cases
    • PID: 5933797, COI: 1:STN:280:DyaF287jt1CjsA%3D%3D
    • Floyd C, Sterling C, Cohn IJ: Cancer of the colon, rectum and anus. Review of 1687 cases. Ann Surg 1966, 163:829–837. DOI: 10.1097/00000658-196606000-00003
    • (1966) Ann Surg , vol.163 , pp. 829-837
    • Floyd, C.1    Sterling, C.2    Cohn, I.J.3
  • 22
    • 0032950293 scopus 로고    scopus 로고
    • Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer [see comments]
    • In this study, patients with B2 colon cancer were entered into five separate trials comparing the combination of 5-FU and leucovorin to observation and were analyzed together an effort to clarify the role of adjuvant chemotherapy. The authors failed to demonstrate any meaningful benefit for the adjuvant chemotherapy. This is the opposite conclusion to that reached by another study looking at pooled data from the NSABP trials
    • International Multicentre Pooled Analysis of B2 Colon Cancer Trials (IMPACT B2) Investigators: Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer [see comments]. J Clin Oncol 1999, 17:1356–1363. In this study, patients with B2 colon cancer were entered into five separate trials comparing the combination of 5-FU and leucovorin to observation and were analyzed together in an effort to clarify the role of adjuvant chemotherapy. The authors failed to demonstrate any meaningful benefit for the adjuvant chemotherapy. This is the opposite conclusion to that reached by another study looking at pooled data from the NSABP trials.
    • (1999) J Clin Oncol , vol.17 , pp. 1356-1363
  • 23
    • 0032949446 scopus 로고    scopus 로고
    • Comparative efficacy of adjuvant chemotherapy in patients with Dukes’ B versus Dukes’ C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04) [see comments]
    • PID: 10334518, COI: 1:STN:280:DyaK1M3msFKrtQ%3D%3D
    • Mamounas E, Wieand S, Wolmark N, et al.: Comparative efficacy of adjuvant chemotherapy in patients with Dukes’ B versus Dukes’ C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04) [see comments]. J Clin Oncol 1999, 17:1349–1355.
    • (1999) J Clin Oncol , vol.17 , pp. 1349-1355
    • Mamounas, E.1    Wieand, S.2    Wolmark, N.3
  • 24
    • 0003298875 scopus 로고    scopus 로고
    • Adjuvant 5FU plus levamisole improves survival in stage II and III colonic cancer, but not in rectal cancer: interim analysis of the Netherlands Adjuvant Colorectal Cancer Project (NACCP)
    • Zoetmulder F, Taal B, VanTinteren H: Adjuvant 5FU plus levamisole improves survival in stage II and III colonic cancer, but not in rectal cancer: interim analysis of the Netherlands Adjuvant Colorectal Cancer Project (NACCP). Proc ASCO 1999, 18:1021.
    • (1999) Proc ASCO , vol.18 , pp. 1021
    • Zoetmulder, F.1    Taal, B.2    VanTinteren, H.3
  • 25
    • 0033523204 scopus 로고    scopus 로고
    • Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers [see comments]
    • PID: 10433618, COI: 1:CAS:528:DyaK1MXlsFyltbc%3D
    • Halling KC, French AJ, McDonnell SK, et al.: Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers [see comments]. J Natl Cancer Inst 1999, 91:1295–1303. DOI: 10.1093/jnci/91.15.1295
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1295-1303
    • Halling, K.C.1    French, A.J.2    McDonnell, S.K.3
  • 26
    • 0032560733 scopus 로고    scopus 로고
    • Micrometastases and survival in stage II colorectal cancer [see comments]
    • PID: 9673300, COI: 1:STN:280:DyaK1czivVKhuw%3D%3D
    • Liefers GJ, Cleton-Jansen AM, van de Velde CJ, et al.: Micrometastases and survival in stage II colorectal cancer [see comments]. N Engl J Med 1998, 339:223–228. DOI: 10.1056/NEJM199807233390403
    • (1998) N Engl J Med , vol.339 , pp. 223-228
    • Liefers, G.J.1    Cleton-Jansen, A.M.2    van de Velde, C.J.3
  • 27
    • 85131863320 scopus 로고    scopus 로고
    • Accuracy of diagnosis of micrometastasis in colorectal cancer by sentinel lymph node mapping technique [abstract]
    • Saha S, Wiese D, Beutler T, et al.: Accuracy of diagnosis of micrometastasis in colorectal cancer by sentinel lymph node mapping technique [abstract]. Proc ASCO 1999, 18:908.
    • (1999) Proc ASCO , vol.18 , pp. 908
    • Saha, S.1    Wiese, D.2    Beutler, T.3
  • 28
    • 0021848221 scopus 로고
    • A randomized controlled trial of adjuvant portal vein cytotoxic perfusion in colorectal cancer
    • PID: 3888335, COI: 1:STN:280:DyaL2M3gtVGquw%3D%3D
    • Taylor I, Machin D, Mullee M, et al.: A randomized controlled trial of adjuvant portal vein cytotoxic perfusion in colorectal cancer. Br J Surg 1985, 72:359–363. DOI: 10.1002/bjs.1800720509
    • (1985) Br J Surg , vol.72 , pp. 359-363
    • Taylor, I.1    Machin, D.2    Mullee, M.3
  • 29
    • 0024988530 scopus 로고
    • Adjuvant therapy of Dukes’ A, B, and C adenocarcinoma of the colon with portal-vein fluorouracil hepatic infusion: preliminary results of National Surgical Adjuvant Breast and Bowel Project Protocol C-02 [see comments]
    • PID: 2202789, COI: 1:STN:280:DyaK3czmt1WlsA%3D%3D
    • Wolmark N, Rockette H, Wickerham DL, et al.: Adjuvant therapy of Dukes’ A, B, and C adenocarcinoma of the colon with portal-vein fluorouracil hepatic infusion: preliminary results of National Surgical Adjuvant Breast and Bowel Project Protocol C-02 [see comments]. J Clin Oncol 1990, 8:1466–1475.
    • (1990) J Clin Oncol , vol.8 , pp. 1466-1475
    • Wolmark, N.1    Rockette, H.2    Wickerham, D.L.3
  • 30
    • 0025283664 scopus 로고
    • Adjuvant therapy for resectable colorectal carcinoma with fluorouracil administered by portal vein infusion: a study of the Mayo Clinic and the North Central Cancer Treatment Group
    • PID: 2369315
    • Beart RW Jr, Moertel CG, Wieand HS, et al.: Adjuvant therapy for resectable colorectal carcinoma with fluorouracil administered by portal vein infusion: a study of the Mayo Clinic and the North Central Cancer Treatment Group. Arch Surg 1990, 125:897–901.
    • (1990) Arch Surg , vol.125 , pp. 897-901
    • Beart, R.W.1    Moertel, C.G.2    Wieand, H.S.3
  • 31
    • 0030851293 scopus 로고    scopus 로고
    • Final results of a phase III clinical trial on adjuvant intraportal infusion with heparin and 5-fluorouracil (5-FU) in resectable colon cancer (EORTC GITCCG 1983–1987). European Organization for Research and Treatment of Cancer. Gastrointestinal Tract Cancer Cooperative Group
    • PID: 9301444, COI: 1:CAS:528:DyaK2sXlvVaksLc%3D
    • Nitti D, Wils J, Sahmoud T, et al.: Final results of a phase III clinical trial on adjuvant intraportal infusion with heparin and 5-fluorouracil (5-FU) in resectable colon cancer (EORTC GITCCG 1983–1987). European Organization for Research and Treatment of Cancer. Gastrointestinal Tract Cancer Cooperative Group. Eur J Cancer 1997, 33:1209–1215. DOI: 10.1016/S0959-8049(97)00052-X
    • (1997) Eur J Cancer , vol.33 , pp. 1209-1215
    • Nitti, D.1    Wils, J.2    Sahmoud, T.3
  • 32
    • 0030985051 scopus 로고    scopus 로고
    • Portal vein chemotherapy for colorectal cancer: A meta-analysis of 4000 patients in 10 studies: Liver Infusion Meta-analysis Group
    • Report on mortality and recurrence from 10 randomized trials in which continuous postoperative PVI of cytotoxic drugs was compared with no further treatment involving about 4000 patients. The results demonstrate a minimal improvement in survival at 5 years. This analysis of a large number of patients failed to substantiate the promising results seen in the initial study
    • Portal vein chemotherapy for colorectal cancer: a meta-analysis of 4000 patients in 10 studies: Liver Infusion Meta-analysis Group. J Natl Cancer Inst 1997, 89:497–505. Report on mortality and recurrence from 10 randomized trials in which continuous postoperative PVI of cytotoxic drugs was compared with no further treatment involving about 4000 patients. The results demonstrate a minimal improvement in survival at 5 years. This analysis of a large number of patients failed to substantiate the promising results seen in the initial study.
    • (1997) . J Natl Cancer Inst , Issue.89 , pp. 497-505
  • 33
    • 0031052731 scopus 로고    scopus 로고
    • Liver resection for colorectal metastases
    • PID: 9060531, COI: 1:STN:280:DyaK2s3htlynsA%3D%3D
    • Fong Y, Cohen AM, Fortner JG, et al.: Liver resection for colorectal metastases. J Clin Oncol 1997, 15:938–946.
    • (1997) J Clin Oncol , vol.15 , pp. 938-946
    • Fong, Y.1    Cohen, A.M.2    Fortner, J.G.3
  • 34
    • 0022339910 scopus 로고
    • Prospective, randomized trial of intravenous versus intraperitoneal 5-fluorouracil in patients with advanced primary colon or rectal cancer
    • PID: 3898450, COI: 1:STN:280:DyaL2MzgtFSgug%3D%3D
    • Sugarbaker PH, Gianola FJ, Speyer JC, et al.: Prospective, randomized trial of intravenous versus intraperitoneal 5-fluorouracil in patients with advanced primary colon or rectal cancer. Surgery 1985, 98:414–422.
    • (1985) Surgery , vol.98 , pp. 414-422
    • Sugarbaker, P.H.1    Gianola, F.J.2    Speyer, J.C.3
  • 35
    • 0033619892 scopus 로고    scopus 로고
    • Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer
    • PID: 10615075, COI: 1:STN:280:DC%2BD3c%2FmtF2qtA%3D%3D, Patients were randomized after resection of hepatic metastases to receive six cycles of hepatic arterial infusion with floxuridine and intravenous fluorouracil, or 6 weeks of similar systemic therapy alone. The actuarial rate of overall survival at 2 years was 86% the group treated with local plus systemic chemotherapy and 72% the group given systemic therapy alone (P=0.03) This is the first study to show a definite benefit for hepatic artery chemotherapy reducing recurrence rate after metastasis resection
    • Kemeny N, Huang Y, Cohen AM, et al.: Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. N Engl J Med 1999, 341:2039–2048. Patients were randomized after resection of hepatic metastases to receive six cycles of hepatic arterial infusion with floxuridine and intravenous fluorouracil, or 6 weeks of similar systemic therapy alone. The actuarial rate of overall survival at 2 years was 86% in the group treated with local plus systemic chemotherapy and 72% in the group given systemic therapy alone (P=0.03) This is the first study to show a definite benefit for hepatic artery chemotherapy in reducing recurrence rate after metastasis resection. DOI: 10.1056/NEJM199912303412702
    • (1999) N Engl J Med , vol.341 , pp. 2039-2048
    • Kemeny, N.1    Huang, Y.2    Cohen, A.M.3
  • 36
    • 0000872960 scopus 로고    scopus 로고
    • Results of the Intergroup prospective randomized study of surgery alone versus continuous hepatic artery infusion of FUDR and continuous systemic infusion of 5FU after hepatic resection of colorectal liver metastasis [abstract]
    • Kemeny M, Adak S, Lipsitz B, et al.: Results of the Intergroup prospective randomized study of surgery alone versus continuous hepatic artery infusion of FUDR and continuous systemic infusion of 5FU after hepatic resection of colorectal liver metastasis [abstract]. Proc ASCO 1999, 18:1012.
    • (1999) Proc ASCO , vol.18 , pp. 1012
    • Kemeny, M.1    Adak, S.2    Lipsitz, B.3
  • 37
    • 0031796145 scopus 로고    scopus 로고
    • US pivotal studies of irinotecan in colorectal carcinoma
    • PID: 9726091, COI: 1:STN:280:DyaK1czpsVWmtg%3D%3D
    • Pitot HC: US pivotal studies of irinotecan in colorectal carcinoma. Oncology 1998, 12(suppl 6):48–53.
    • (1998) Oncology , vol.12 , pp. 48-53
    • Pitot, H.C.1
  • 38
    • 0029964872 scopus 로고    scopus 로고
    • Current status of colorectal cancer: CPT-11 (irinotecan), a therapeutic innovation
    • PID: 8943658, COI: 1:CAS:528:DyaK2sXjvVWhsQ%3D%3D
    • Cunningham D: Current status of colorectal cancer: CPT-11 (irinotecan), a therapeutic innovation. Eur J Cancer 1996, 32A(suppl 3):S1-S8. DOI: 10.1016/0959-8049(96)00290-0
    • (1996) Eur J Cancer , vol.32A , pp. S1-S8
    • Cunningham, D.1
  • 39
    • 0032928639 scopus 로고    scopus 로고
    • The medical treatment of colorectal cancer: actual status and new developments
    • PID: 10370599
    • Van Cutsem E, Peeters M, Verslype C, et al.: The medical treatment of colorectal cancer: actual status and new developments. Hepatogastroenterology 1999, 46:709–716.
    • (1999) Hepatogastroenterology , vol.46 , pp. 709-716
    • Van Cutsem, E.1    Peeters, M.2    Verslype, C.3
  • 40
    • 0000449676 scopus 로고    scopus 로고
    • A randomized trial of leucovorin and 5-fluorouracil with or without oxaliplatin in advanced colorectal cancer
    • de Gramont A, Figer A, Seymour M, et al.: A randomized trial of leucovorin and 5-fluorouracil with or without oxaliplatin in advanced colorectal cancer. Proc ASCO 1998, 17:257a.
    • (1998) Proc ASCO , vol.17 , pp. 257a
    • de Gramont, A.1    Figer, A.2    Seymour, M.3
  • 41
    • 0344109583 scopus 로고    scopus 로고
    • Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
    • Meta-analysis Group in Cancer: Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 1998, 16:301–308.
    • (1998) J Clin Oncol , vol.16 , pp. 301-308
  • 42
    • 0031060206 scopus 로고    scopus 로고
    • Phase II study of UFT plus leucovorin in colorectal cancer
    • PID: 8978580, COI: 1:CAS:528:DyaK2sXlslejsw%3D%3D
    • Pazdur R: Phase II study of UFT plus leucovorin in colorectal cancer. Oncology 1997, 54(suppl 1):19–23. DOI: 10.1159/000227741
    • (1997) Oncology , vol.54 , pp. 19-23
    • Pazdur, R.1
  • 43
    • 6544280260 scopus 로고    scopus 로고
    • UFT plus calcium folinate vs. 5-FU plus calcium folinate in colon cancer
    • PID: 10442360, COI: 1:STN:280:DyaK1MzntV2nug%3D%3D
    • Smith R, Wickerham DL, Wieand HS, et al.: UFT plus calcium folinate vs. 5-FU plus calcium folinate in colon cancer. Oncology 1999, 13(suppl 3):44–47.
    • (1999) Oncology , vol.13 , pp. 44-47
    • Smith, R.1    Wickerham, D.L.2    Wieand, H.S.3
  • 44
    • 0033002465 scopus 로고    scopus 로고
    • Developments in fluoropyrimidine therapy for gastrointestinal cancer
    • PID: 10416885
    • Van Cutsem E, Peeters M: Developments in fluoropyrimidine therapy for gastrointestinal cancer. Curr Opin Oncol 1999, 11:312–317. DOI: 10.1097/00001622-199907000-00012
    • (1999) Curr Opin Oncol , vol.11 , pp. 312-317
    • Van Cutsem, E.1    Peeters, M.2
  • 45
    • 0033371543 scopus 로고    scopus 로고
    • Phase II study of raltitrexed (Tomudex) in chemotherapy-pretreated patients with advanced colorectal cancer: Tomudex Cooperative Study Group
    • PID: 10573207, COI: 1:CAS:528:DyaK1MXntlGhtrs%3D
    • Sato A, Kurihara M, Horikoshi N, et al.: Phase II study of raltitrexed (Tomudex) in chemotherapy-pretreated patients with advanced colorectal cancer: Tomudex Cooperative Study Group. Anticancer Drugs 1999, 10:741–748. DOI: 10.1097/00001813-199909000-00008
    • (1999) Anticancer Drugs , vol.10 , pp. 741-748
    • Sato, A.1    Kurihara, M.2    Horikoshi, N.3
  • 46
    • 0033103493 scopus 로고    scopus 로고
    • Raltitrexed (Tomudex) in combination treatment for colorectal cancer: new perspectives
    • PID: 10645206
    • Van Cutsem E: Raltitrexed (Tomudex) in combination treatment for colorectal cancer: new perspectives. Eur J Cancer 1999, 35 (suppl 1):S1-S2. DOI: 10.1016/S0959-8049(99)00040-4
    • (1999) Eur J Cancer , vol.35 , pp. S1-S2
    • Van Cutsem, E.1
  • 47
    • 0343965762 scopus 로고    scopus 로고
    • Monoclonal antibody therapy for resected Dukes’ C colorectal cancer: seven-year outcome of a multicenter randomized trial
    • PID: 9586892, COI: 1:CAS:528:DyaK1cXjtFOqs7w%3D, Patients with resected Dukes’ C colorectal cancer were randomized to infusions of 17-1A antibody, 500 mg postoperatively, followed by four monthly doses of 100 mg, or to observation. At 7 years, there was a reduction overall mortality by 32% (P=0.01) and the recurrence rate by 23% (P=0.07). This is one of the few studies showing this magnitude of benefit with immunotherapy the adjuvant setting
    • Riethmuller G, Holz E, Schlimok G, et al.: Monoclonal antibody therapy for resected Dukes’ C colorectal cancer: seven-year outcome of a multicenter randomized trial. J Clin Oncol 1998, 16:1788–1794. Patients with resected Dukes’ C colorectal cancer were randomized to infusions of 17-1A antibody, 500 mg postoperatively, followed by four monthly doses of 100 mg, or to observation. At 7 years, there was a reduction in overall mortality by 32% (P=0.01) and in the recurrence rate by 23% (P=0.07). This is one of the few studies showing this magnitude of benefit with immunotherapy in the adjuvant setting.
    • (1998) J Clin Oncol , vol.16 , pp. 1788-1794
    • Riethmuller, G.1    Holz, E.2    Schlimok, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.