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PID: 9586892, COI: 1:CAS:528:DyaK1cXjtFOqs7w%3D, Patients with resected Dukes’ C colorectal cancer were randomized to infusions of 17-1A antibody, 500 mg postoperatively, followed by four monthly doses of 100 mg, or to observation. At 7 years, there was a reduction overall mortality by 32% (P=0.01) and the recurrence rate by 23% (P=0.07). This is one of the few studies showing this magnitude of benefit with immunotherapy the adjuvant setting
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Riethmuller G, Holz E, Schlimok G, et al.: Monoclonal antibody therapy for resected Dukes’ C colorectal cancer: seven-year outcome of a multicenter randomized trial. J Clin Oncol 1998, 16:1788–1794. Patients with resected Dukes’ C colorectal cancer were randomized to infusions of 17-1A antibody, 500 mg postoperatively, followed by four monthly doses of 100 mg, or to observation. At 7 years, there was a reduction in overall mortality by 32% (P=0.01) and in the recurrence rate by 23% (P=0.07). This is one of the few studies showing this magnitude of benefit with immunotherapy in the adjuvant setting.
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