Two mutants of human heparin binding protein (CAP37): Toward the understanding of the nature of lipid A/LPS and BPTI binding

Proteins: Structure, Function and Genetics

Volumn 42, Issue 4, 2001, Pages 442-451

  Kastrup, Jette S ^a   Linde, Viggo ^a,b   Pedersen, Anja K ^a   Stoffer, Bjarne ^a   Iversen, Lars F ^b   Larsen, Ingrid K ^a   Rasmussen, Poul B ^b   Flodgaard, Hans J ^b   Bjrn, Sren E ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

Author keywords

BPTI binding site; Il 6 release; Inactive serine protease homologue; Infection and inflammation; Lipopolysaccharide binding site; X ray crystallography

Indexed keywords

APROTININ; ARGININE; CYTOKINE; HEPARIN BINDING PROTEIN; LIPID A; LIPOPOLYSACCHARIDE; PHENYLALANINE;

ARTICLE; BINDING AFFINITY; CYTOKINE RELEASE; HOST RESISTANCE; HUMAN; HUMAN CELL; INFLAMMATION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; APROTININ; BINDING SITES; BLOOD PROTEINS; CARRIER PROTEINS; CATTLE; CRYSTALLIZATION; GLYCOPROTEINS; HUMANS; INTERLEUKIN-6; IODINE ISOTOPES; LIPID A; LIPOPOLYSACCHARIDES; MONOCYTES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; X-RAY DIFFRACTION;

BOVINAE;

EID: 0035283167     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0134(20010301)42:4<442::AID-PROT30>3.0.CO;2-S     Document Type: Article

References (35)

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5. Covalent structure of two novel neutrophile leukocyte-derived proteins of porcine and human origin: Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities
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9. Molecular mapping and detoxification of the lipid A binding site by synthetic peptides
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11. The interaction of catalytically inactive proteolytic enzymes with protein inhibitors methyl-chymotrypsin
12. Heparin-binding protein (CAP37) is internalized in monocytes and increases LPS-induced monocyte activation
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14. Characterization of recombinant human HBP/CAP37/azurocidin, a pleiotropic mediator of inflammation-enhancing LPS-induced cytokine release from monocytes
15. Comparison of the effects of methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone-inhibited neutrophil elastase with the effects of its naturally occurring mutationally inactivated homologue (HBP) on fibroblasts and monocytes in vitro
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