Potential antidepressants displayed combined α2-adrenoceptor antagonist and monoamine uptake inhibitor properties

Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2001, Pages 787-805

  Cordi, A A ^a   Berque Bestel, I ^b   Persigand, T ^a   Lacoste, J M ^a   Newman Tancredi, A ^a   Audinot, V ^a   Millan, M J ^a  

^a INSTITUT DE RECHERCHES SERVIER   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4(5) [(3,4 DIHYDRO 2 NAPHTHALENYL)METHYL] 4,5 DIHYDROIMIDAZOLE; 4(5) [(5 FLUOROINDAN 2 YL)METHYL] 4,5 DIHYDROIMIDAZOLE; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIDEPRESSANT AGENT; ATIPAMEZOLE; FLUOXETINE; MONOAMINE OXIDASE INHIBITOR; NAPAMEZOLE; NORADRENALIN; SEROTONIN; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG;

ADRENERGIC TRANSMISSION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; NEUROTRANSMISSION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC UPTAKE INHIBITORS; ANIMALS; ANTIDEPRESSIVE AGENTS; BINDING SITES; BINDING, COMPETITIVE; CEREBRAL CORTEX; CHO CELLS; CRICETINAE; FRONTAL LOBE; IMIDAZOLES; INDANS; LIGANDS; NOREPINEPHRINE; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; SEROTONIN UPTAKE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035282802     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001040g     Document Type: Article

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