Stimulation and inhibition of nitric oxide production in macrophages and neural cells as observed by spin trapping

Free Radical Biology and Medicine

Volumn 22, Issue 1-2, 1997, Pages 1-9

  Norby, Shong Wan ^a   Weyhenmeyer, James A ^b   Clarkson, R B ^a,b  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

EPR; Free radical; In vitro; Inhibition; Macrophages; Neural cells; Nitric oxide; Spin trapping; Stimulation

Indexed keywords

ARGININE; BACTERIUM LIPOPOLYSACCHARIDE; CALCIUM CHLORIDE; GAMMA INTERFERON; N METHYL DEXTRO ASPARTIC ACID; N(G) METHYLARGININE; NITRIC OXIDE; POTASSIUM CHLORIDE; LIPOPOLYSACCHARIDE; N METHYLASPARTIC ACID;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; MACROPHAGE; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL LINE; CELL STRAIN; DRUG EFFECT; MACROPHAGE ACTIVATION; METABOLISM; NEUROBLASTOMA; PHYSIOLOGY; RAT; SPIN TRAPPING; STIMULATION;

ANIMALIA; BACTERIA (MICROORGANISMS);

ANIMALS; CALCIUM CHLORIDE; CELL LINE; ELECTRON SPIN RESONANCE SPECTROSCOPY; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MICE; N-METHYLASPARTATE; NEUROBLASTOMA; NEURONS; NITRIC OXIDE; PC12 CELLS; RATS; SPIN TRAPPING; STIMULATION, CHEMICAL; TUMOR CELLS, CULTURED;

EID: 0030636838     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(96)00217-1     Document Type: Article

References (75)

1. Moncada S., Palmer M. J., Higgs E. A. Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43:1991;109-142.
2. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:1992;3051-3064.
3. Liew F. Y., Cox F. E. G. Nonspecific defence mechanism: The role of nitric oxide. Immunol. Today. 12:1991;A17-A21.
4. Mellouk S., Green S. J., Nacy C. A., Hoffman S. L. IFN- γ inhibits development of Plasmodium berghei exoerythrocytic stages in hepatocytes by an L-arginine-dependent effector mechanism. J. Immunol. 146:1991;3971-3976.
5. Green S. J., Meltzer M. S., Hibbs J. B. Jr., Nacy C. A. Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism. J. Immunol. 144:1990;278-283.
6. Nathan C., Hibbs J. B. Jr. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opin. Immunol. 3:1991;65-70.
7. Granger D. L., Perfect J. R., Durack D. T. Macrophage-mediated fungistasis: Requirement for a macromolecular component in serum. J. Immunol. 137:1986;693-701.
8. Drapier J.-C., Pellat C., Henry Y. Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages. J. Biol. Chem. 266:1991;10162-10167.
9. Tucker S. D., Auzenne E. J., Sivaramakrishnan M. R. Inhibition of tumor cell mitochondrial respiration by macrophage cytotoxic mediators distinct from interferon- γ J. Leukoc. Biol. 53:1993;138-143.
10. Keller R. Induction of tumouricidal activity and generation of reactive nitrogen intermediates in macrophages: A comparative analysis in vitro and in vivo. Moncada S., Higgs E. A. Nitric oxide from L-arginine: A bioregulatory system. 1990;409-413 Elsevier Science Publishers, New York.
11. Stuehr D. J., Nathan C. F. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J. Exp. Med. 169:1989;1543-1555.
12. Hibbs J. B. Jr., Taintor R. R., Vavrin Z., Rachlin E. M. Nitric oxide: A cytotoxic activated macrophage effector molecule. Biochem. Biophys. Res. Commun. 157:1988;87-94.
13. Bredt D. S., Hwang P. M., Snyder S. H. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature. 347:1990;768-770.
14. Dawson T. M., Bredt D. S., Fotuhi M., Hwang P. M., Snyder S. H. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc. Natl. Acad. Sci. USA. 88:1991;7797-7801.
15. Stevens C. Is nitric oxide the "Retrograde Messenger"? Science. 254:1991;1296-1297.
16. O'Dell T. J., Hawkins R. D., Kandel E. R., Arancio O. Tests of the roles of two diffusible substances in long-term potentiation: Evidence for nitric oxide as a possible early retrograde messenger. Proc. Natl. Acad. Sci. USA. 88:1991;11285-11289.
17. Böhme G. A., Bon C., Stutzmann J.-M., Doble A., Blanchard J.-C. Possible involvement of nitric oxide in long-term potentiation. Eur. J. Pharmacol. 199:1991;379-381.
18. Shibuki K., Okada D. Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum. Nature. 349:1991;326-328.
19. Ignarro L. J. Signal transduction mechanisms involving nitric oxide. Biochem. Pharmacol. 41:1991;485-490.
20. Ignarro L. J. Nitric oxide: A novel signal transduction mechanism for transcellular communication. Hypertension. 16:1990;477-483.
21. Ignarro L. J. Haem-dependent activation of guanylate cyclase and cyclic GMP formation by endogenous nitric oxide: A unique transduction mechanism for transcellular signaling. Pharmacol. & Toxicol. 67:1990;1-7.
22. Ferreira S. H., Duarte I. D. G., Lorenzetti B. B. The molecular mechanism of action of peripheral morphine analgesia: Stimulation of the cGMP system via nitric oxide release. Eur. J. Pharmacol. 201:1991;121-122.
23. Duarte I. D. G., Lorenzetti R. B., Ferreira S. H. Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway. Eur. J. Pharmacol. 186:1990;289-293.
24. Duarte I. D. G., Lorenzetti B. B., Ferreira S. H. Acetylcholine induces peripheral analgesia by the release of nitric oxide. Moncada S., Higgs E. A. Nitric oxide from L-arginine: A bioregulatory system. 1990;165-170 Elsevier Science Publishers, New York.
25. Dawson V. L., Dawson T. M., London E. D., Bredt D. S., Snyder S. H. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA. 88:1991;6368-6371.
26. 3H]-dopamine from striatal slices. Neuro Report. 3:1992;409-412.
27. Kader A., Frazzini V. I., Solomon R. A., Trifiletti R. R. Nitric oxide production during focal cerebral ischemia in rats. Stroke. 24:1993;1709-1716.
28. +. Biochem. Biophys. Res. Commun. 199:1994;1245-1249.
29. McCall T., Palmer R. M. J., Boughton-Smith N., Whittle B. J. R., Moncada S. The L-arginine:nitric oxide pathway in neutrophils. Moncada S., Higgs E. A. Nitirc oxide from L-arginine: A bioregulatory system. 1990;257-265 Elsevier Science Publishers, New York.
30. Wright C. D., Mülsch A., Busse R., Osswald H. Generation of nitric oxide by human neutrophils. Biochem. Biophys. Res. Commun. 160:1989;813-819.
31. Nussler A. K., Di Silvio M., Billiar T. R., Hoffman R. A., Geller D. A., Selby R., Madariaga J., Simmons R. L. Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J. Exp. Med. 176:1992;261-264.
32. Curran R. D., Billiar T. R., Stuehr D. J., Hofmann K., Simmons R. L. Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells. J. Exp. Med. 170:1989;1769-1774.
33. Schmidt H. H. H. W., Warner T. D., Ishii K., Sheng H., Murad F. Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science. 255:1992;721-723.
34. Kilbourn R., Belloni P. Endothelial cells produce nitrogen oxides in response to interferon- γ , tumour necrosis factor and endotoxin. Moncada S., Higgs E. A. Nitric oxide from L-arginine: A bioregulatory system. 1990;61-67 Elsevier Science Publishers, New York.
35. Ignarro L. J., Buga G, M., Wood K. S., Byrns R. E., Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA. 84:1987;9265-9269.
36. Hevel J. M., Marletta M. A. Nitric-oxide synthase assays. Methods Enzymol. 233:1994;250-258.
37. Hevel J. M., White K. A., Marletta M. A. Purification of the inducible murine macrophage nitric oxide synthase. J. Biol. Chem. 266:1991;22789-22791.
38. Pollock J. S., Förstermann U., Mitchell J. A., Warner T. D., Schmidt H. H. H. W., Nakane M., Murad F. Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc. Natl. Acad. Sci. USA. 88:1991;10480-10484.
39. Stuehr D. J., Cho H. J., Kwon N. S., Weise M. F., Nathan C. F. Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: An FAD- and FMN-containing flavoprotein. Proc. Natl. Acad. Sci. USA. 88:1991;7773-7777.
40. Yui Y., Hattori R., Kosuga K., Eizawa H., Hiki K., Kawai C. Purification of nitric oxide synthase from rat macrophages. J. Biol. Chem. 266:1991;12544-12547.
41. Bredt D. S., Snyder S. H. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc. Natl. Acad. Sci. USA. 87:1990;682-685.
42. Lowenstein C. J., Glatt C. S., Bredt D. S., Snyder S. H. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc. Natl. Acad. Sci. USA. 88:1992;6711-6715.
43. Xie Q.-W., Cho H. J., Calaycay J., Mumford R. A., Swiderek K. M., Lee T. D., Ding A., Troso T., Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science. 256:1992;225-228.
44. Lyons C. R., Orloff G. J., Cunningham J. M. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J. Biol. Chem. 267:1992;6370-6374.
45. Bredt D. S., Hwang P. M., Glatt C. E., Lowenstein C., Reed R. R., Snyder S. H. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature. 351:1991;714-718.
46. Lamas S., Marsden P. A., Li G. K., Tempst P., Michel T. Endothelial nitric oxide synthase: Molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc. Natl. Acad. Sci. USA. 89:1992;6348-6352.
47. Janssens S. P., Shimouchi A., Quertermous T., Bloch D. B., Bloch K. D. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J. Biol. Chem. 267:1992;14519-14522.
48. Tayeh M. A., Marletta M. A. Tetrahydrobiopterin is required for the oxidation of arginine to nitric oxide by macrophages. Moncada S., Higgs E. A. Nitric oxide from L-arginine: A bioregulatory system. 1990;183-188 Elsevier Science Publishers, New York.
49. Stuehr D. J., Kwon N. S., Nathan C. F. FAD and GSH participate in macrophage synthesis of nitric oxide. Biochem. Biophys. Res. Commun. 168:1990;558-565.
50. 2+/calmodulin-dependent nitric oxide synthase from porcine cerebellum. Cofactor-role of tetrahydrobiopterin. FEBS Lett. 277:1990;215-219.
51. Leone A. M., Palmer R. M. J., Knowles R. G., Francis P. L., Ashton D. S., Moncada S. Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline. J. Biol. Chem. 266:1991;23790-23795.
52. Cox G. W., Melillo G., Chattopadhyay U., Mullet D., Fertel R. H., Varesio L. Tumor necrosis factor- α -dependent production of reactive nitrogen intermediates mediates IFN- γ plus IL-2-induced murine macrophage tumoricidal activity. J. Immunol. 149:1992;3290-3296.
53. Marletta M. A., Yoon P. S., Iyengar R., Leaf C. D., Wishnok J. S. Macrophage oxidation of L-arginine to nitrite and nitrate: Nitric oxide is an intermediate. Biochemistry. 27:1988;8706-8711.
54. Ding A. H., Nathan C. F., Stuehr D. J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. J. Immunol. 141:1988;2407-2412.
55. Drapier J.-C., Wietzerbin J., Hibbs J. B. Jr. Interferon- γ and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages. Eur. J. Immunol. 18:1988;1587-1592.
56. Stuehr D. J., Marletta M. A. Further studies on murine macrophage synthesis of nitrite and nitrate. IARC Sci. Publ. 84:1987;335-339.
57. Archer S. Measurement of nitric oxide in biological models. FASEB J. 7:1993;349-360.
58. ++ dithiocarbamate spin trap. Free Radic. Res. 23:1995;287-295.
59. Komarov A. M., Lai C.-S. Detection of nitric oxide production in mice by spin-trapping electron paramagnetic resonance spectroscopy. Biochim. Biophys. Acta. 1272:1995;29-36.
60. Lai C.-S., Komarov A. M. Spin trapping of nitric oxide produced in vivo in septic-shock mice. FEBS Lett. 345:1994;120-124.
61. Komarov A. M., Mattson D., Jones M. M., Singh P. K., Lai C.-S. In vivo spin trapping of nitric oxide in mice. Biochem. Biophys. Res. Commun. 195:1993;1191-1198.
62. Lancaster J. R. Jr., Hibbs J. B. Jr. EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc. Natl. Acad. Sci. USA. 87:1990;1223-1227.
63. Kosaka H., Watanabe M., Yoshihara H., Harada N., Shiga T. Detection of nitric oxide production in lipopolysaccharide-treated rats by ESR using carbon monoxide hemoglobin. Biochem. Biophys. Res. Commun. 184:1992;1119-1124.
64. Maples K., Sandstrom T., Su Y., Henderson R. The nitric oxide/heme protein complex as a biologic marker of exposure to nitrogen dioxide in humans, rats, and in vitro models. Am. J. Respir. Cell Mol. Biol. 4:1991;538-543.
65. Vanin A. F., Men'hikow G. B., Moroz I. A., Mordvintcev P. I., Serezhenkow V. A., Burbaev D. S. The source of non-heme iron that binds nitric oxide in cultivated macrophages. Biochim. Biophys. Acta. 1135:1992;275-279.
66. Sato S., Tominage T., Ohnishi T., Ohnishi S. T. Electron paramagnetic resonance study on nitric oxide production during brain focal ischemia and reperfusion in the rat. Brain Res. 647:1994;91-96.
67. Mordvintcev P., Mülsch A., Busse R., Vanin A. On-line detection of nitric oxide formation in liquid aqueous phase by electron paramagnetic resonance spectroscopy. Anal. Biochem. 199:1991;142-146.
68. Clarkson R. B., Norby S. W., Smirnov A., Boyer S., Vahidi N., Nims R. W., Wink D. A. Direct measurement of the accumulation and mitochondrial conversion of nitric oxide within Chinese hamster ovary cells using an intracellular electron paramagnetic resonance technique. Biochim. Biophys. Acta. 1243:1995;496-502.
69. Shinobu L. A., Jones S. G., Jones M. M. Sodium N-Methyl-D-Glucamine dithiocarbamate and cadmium intoxication. Acta Pharmacol. Toxicol. 54:1984;189-194.
70. Maragos C. M., Morley D., Wink D. A., Dunams T. M., Saavedra J. E., Hoffman A., Bove A. A., Isaac L., Hrabie J. A., Keefer L. K. Complexes of ·NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J. Med. Chem. 34:1991;3242-3247.
71. Bredt D. S., Snyder S. H. Nitric oxide - A physiological messenger molecule. Annu. Rev. Biochem. 63:1994;175-195.
72. Rees D. D., Palmer R. M. J., Schulz R., Hodson H. F., Moncada S. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol. 101:1990;746-752.
73. Fenton H. J. H. Oxidation of tartaric acid in the presence of iron. J. Chem. Soc. 65:1894;899-910.
74. McCord J, M. Oxygen-derived free radicals in postischemic tissue injury. N. Engl. J. Med. 312:1985;159-163.
75. Riley P. A. Free radicals in biology: Oxidative stress and the effects of ionizing radiation. Int. J. Radiat. Biol. 65:1994;27-33.