Overexpression of fibroblast growth factor 1 in MCF-7 breast cancer cells facilitates tumor cell dissemination but does not support the development of macrometastases in the lungs or lymph nodes

Cancer Research

Volumn 59, Issue 19, 1999, Pages 5023-5029

  Zhang, Lurong ^a,b   Kharbanda, Samir ^a   McLeskey, Sandra W ^a,b   Kern, Francis G ^b,c  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 1;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CELL STRAIN MCF 7; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LUNG METASTASIS; LYMPH NODE METASTASIS; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR EMBOLISM; TUMOR VASCULARIZATION;

ANIMALS; ANTIGENS, CD31; BREAST NEOPLASMS; FEMALE; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASM METASTASIS; OVARIECTOMY; RECOMBINANT PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033213955     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Ellis, L. M., and Fidler, I. J. Angiogenesis and metastasis. Eur. J. Cancer, 32A: 2451-2460, 1996.
2. Weiss, L. Metastatic inefficiency. Adv. Cancer Res., 54: 159-211, 1990.
3. Woodhouse, E. C., Chuaqui, R. F., and Liotta, L. A. General mechanisms of metastasis. Cancer (Phila.), 80: 1529-1537, 1997.
4. Stetler-Stevenson, W. G., Liotta, L. A., and Kleiner, D. E. J. Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. FASEB J., 7: 1434-1441, 1993.
5. Chambers, A. F., and Matrisian, L. M. Changing views of the role of matrix metalloproteinases in metastasis. J. Natl. Cancer Inst., 89: 1260-1270, 1997.
6. Zetter, B. R. Adhesion molecules in tumor metastasis. Semin. Cancer Biol., 4: 219-229, 1993.
7. McCormick, B. A., and Zetter, B. R. Adhesive interactions in angiogenesis and metastasis. Pharmacol. Ther., 53: 239-260, 1992.
8. Zetter, B. R. Angiogenesis and tumor metastasis. Annu. Rev. Med., 49: 407-424, 1998.
9. Folkman, J., and Shing, Y. Angiogenesis. J. Biol. Chem., 267: 10931-10934, 1992.
10. McCulloch, P., Choy, A., and Martin, L. Association between tumour angiogenesis and tumour cell shedding into effluent venous blood during breast cancer surgery. Lancet, 346: 1334-1335, 1995.
11. Liotta, L. A., Kleinerman, J., and Saidel, G. M. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res., 34: 997-1004, 1974.
12. Kim, J., Yu, W., Kovalski, K., and Ossowski, L. Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay. Cell, 94: 353-362, 1998.
13. Johnson, P. W., Burchill, S. A., and Selby, P. J. The molecular detection of circulating tumour cells. Br. J. Cancer, 72: 268-276, 1995.
14. Peck, K., Sher, Y. P., Shih, J. Y., Roffler, S. R., Wu, C. W., and Yang, P. C. Detection and quantitation of circulating cancer cells in the peripheral blood of lung cancer patients. Cancer Res., 58: 2761-2765, 1998.
15. Racila, E., Euhus, D., Weiss, A. J., Rao, C., McConnell, J., Terstappen, L. W., and Uhr, J. W. Detection and characterization of carcinoma cells in the blood. Proc. Natl. Acad. Sci. USA, 95: 4589-4594, 1998.
16. Sun, Y., Lin, J., Katz, A. E., and Fisher, P. B. Human prostatic carcinoma oncogene PTI-1 is expressed in human tumor cell lines and prostate carcinoma patient blood samples. Cancer Res., 57: 18-23, 1997.
17. Mattano, L. A. J., Moss, T. J., and Emerson, S. G. Sensitive detection of rare circulating neuroblastoma cells by the reverse transcriptase-polymerase chain reaction. Cancer Res., 52: 4701-4705, 1992.
18. -7. Proc. Natl. Acad. Sci. USA, 92: 537-541, 1995.
19. Moss, T. J., and Sanders, D. G. Detection of neuroblastoma cells in blood. J. Clin. Oncol., 8: 736-740, 1990.
20. Ts'o, P. O., Pannek, J., Wang, Z. P., Lesko, S. A., Bova, G. S., and Partin, A. W. Detection of intact prostate cancer cells in the blood of men with prostate cancer. Urology, 49: 881-885, 1997.
21. Terstappen, L. W., Rao, C., Gross, S., Kotelnikov, V., Racilla, E., Uhr. J., and Weiss, A. Flow cytometry: principles and feasibility in transfusion medicine. Enumeration of epithelial derived tumor cells in peripheral blood. Vox Sang., 74 (Suppl. 2): 269-274, 1998.
22. Chambers, A. F., MacDonald, I. C., Schmidt, E. E., Koop, S., Morris, V. L., Khokha, R., and Groom, A. C. Steps in tumor metastasis: new concepts from intravital videomicroscopy. Cancer Metastasis Rev., 14: 279-301, 1995.
23. Price, J. E. Analyzing the metastatic phenotype. J. Cell. Biochem., 56: 16-22, 1994.
24. McLeskey, S. W., Kurebayashi, J., Honig, S. F., Zwiebel, J., Lippman, M. E., Dickson, R. B., and Kern, F. G. Fibroblast growth factor 4 transfection of MCF-7 cells produces cell lines that are tumorigenic and metastatic in ovariectomized or tamoxifen-treated athymic nude mice. Cancer Res., 53: 2168-2177, 1993.
25. Kurebayashi, J., McLeskey, S. W., Johnson, M. D., Lippman, M. E., Dickson, R. B., and Kern, F. G. Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and lacZ. Cancer Res., 53: 2178-2187, 1993.
26. Zhang, L., Kharbanda. S., Chen, D., Bullocks, J., Miller, D. L., Ding, I. Y. F., Hanfelt, J., McLeskey, S. W., and Kern, F. G. MCF-7 breast carcinoma cells overexpressing FGF-1 form vascularized, metastatic tumors in ovariectomized or tamoxifen-treated nude mice. Oncogene, 15: 2093-2108, 1997.
27. McLeskey, S. W., Tobias, C. A., Vezza, P. R., Filie, A. C., Kern, F. G., and Hanfelt, J. Tumor growth of FGF or VEGF transfected MCF-7 breast carcinoma cells correlates with density of specific microvessels independent of the transfected angiogenic factor. Am. J. Pathol., 153: 1993-2006, 1998.
28. Engel, L. W., and Young, N. A. Human breast carcinoma cells in continuous culture: a review. Cancer Res., 38: 4327-4339, 1978.
29. Bullocks, J., Zhang, L., Ding, I. Y. F., McLeskey, S. W., Tobias, C. A., Miller, D. L., and Kern, F. G. Overexpression of vascular endothelial growth factor (VEGF) in MCF-7 breast carcinoma cells facilitates growth in tamoxifen-treated nude mice and tumor cell dissemination. Proc. Am. Assoc. Cancer Res., 38: A3521, 1997.
30. O'Reilly, M. S., Holmgren, L., Shing, Y., Chen, C., Rosenthal, R. A., Moses, M., Lane, W. S., Cao, Y., Sage, E. H., and Folkman, J. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell, 79: 315-328, 1994.
31. O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., and Folkman, J. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 88: 277-285, 1997.
32. Miyake, H., Hara, I., Yoshimura, K., Eto, H., Arakawa, S., Wada, S., Chihara, K., and Kamidono, S. Introduction of basic fibroblast growth factor gene into mouse renal cell carcinoma cell line enhances its metastatic potential. Cancer Res., 56: 2440-2445, 1996.
33. Quigley, J. P., and Armstrong, P. B. Tumor cell intravasation alu-cidated: the chick embryo opens the window. Cell, 94: 281-284, 1998.
34. Mazzieri, R., Masiero, L., Zanetta, L., Monea, S., Onisto, M., Garbisa, S., and Mignatti, P. Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants. EMBO J., 16: 2319-2332, 1997.
35. Sato, Y., and Rifkin, D. B. Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis. S. Cell Biol., 107: 1199-1205, 1988.
36. Rusnati, M., Dell'Era, P., Urbinati, C., Tanghetti, E., Massardi, M. L., Nagamine, Y., Monti, E., and Presta, M. A distinct basic fibroblast growth factor (FGF-2)/FGF receptor interaction distinguishes urokinase-type plasminogen activator induction from mitogenicity in endothelial cells. Mol. Biol. Cell, 7: 369-381, 1996.
37. Dell'Era, P., Mohammadi, M., and Presta, M. Different tyrosine autophosphorylation requirements in fibroblast growth factor receptor-1 mediate urokinase-type plasminogen activator induction and mitogenesis. Mol. Biol. Cell, 10: 23-33, 1999.
38. Emanuels, A. G., Kern, F. G., and McLeskey, S. W. Urokinase plasminogen activator expression is up-regulated in MCF-7 cells transfected with angiogenic growth factors and is inhibited by estrogen treatment. Proc. Am. Assoc. Cancer Res., 40: 4561, 1999.
39. Morris, V. L., Koop, S., MacDonald, I. C., Schmidt, E. E., Grattan, M., Percy, D., Chambers, A. F., and Groom, A. C. Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth. Clin. Exp. Metastasis, 12: 357-367, 1994.
40. Koop, S., MacDonald, I. C., Luzzi, K., Schmidt, E. E., Morris, V. L., Grattan, M., Khokha, R., Chambers, A. F., and Groom, A. C. Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate. Cancer Res., 55: 2520-2523, 1995.
41. Koop, S., Schmidt, E. E., MacDonald, I. C., Morris, V. L., Khokha, R., Grattan, M., Leone, J., Chambers, A. F., and Groom, A. C. Independence of metastatic ability and extravasation: metastatic ras-transformed and control fibroblasts extravasate equally well. Proc. Natl. Acad. Sci. USA, 93: 11080-11084, 1996.
42. MacDonald, I. C., Schmidt, E. E., Morris, V. L., Chambers, A. F., and Groom, A. C. Intravital videomicroscopy of the chorioallantoic microcirculation: a model system for studying metastasis. Microvasc. Res., 44: 185-199, 1992.
43. Koop, S., Khokha, R., Schmidt, E. E., MacDonald, I. C., Morris, V. L., Chambers, A. F., and Groom, A. C. Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth. Cancer Res., 54: 4791-4797, 1994.
44. Zhang, L., Kharbanda, S., Hanfelt, J., and Kern, F. G. Both autocrine and paracrine effects of transfected acidic fibroblast growth factor are involved in the estrogen-independent and antiestrogen-resistant growth of MCF-7 breast cancer cells. Cancer Res., 58: 352-361, 1998.
45. Yoneda, T., Sasaki, A., and Mundy, G. R. Osteolytic bone metastasis in breast cancer. Breast Cancer Res. Treat., 32: 73-84, 1994.
46. Janicke, R. U., Sprengart, M. L., Wati, M. R., and Porter, A. G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem., 273: 9357-9360, 1998.