Skeletal dysplasia and defective chondrocyte differentiation by targeted overexpression of fibroblast growth factor 9 in transgenic mice

Journal of Bone and Mineral Research

Volumn 14, Issue 11, 1999, Pages 1909-1915

  Garofalo, Silvio ^a,b,c   Kliger Spatz, Michal ^d   Cooke, Jeremy L ^a   Wolstin, Orit ^d   Lunstrum, Gregory P ^a   Moshkovitz, Sharon M ^d   Horton, William A ^a,b   Yayon, Avner ^d  

^a SHRINERS HOSPITAL FOR CHILDREN   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR;

ACHONDROPLASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DYSPLASIA; BONE GROWTH; CARTILAGE CELL; CELL DIFFERENTIATION; CHONDRODYSPLASIA; CHONDROGENESIS; CONTROLLED STUDY; DWARFISM; ENCHONDRAL OSSIFICATION; GENE MUTATION; GENE OVEREXPRESSION; GENE TARGETING; GROWTH PLATE; NONHUMAN; PHENOTYPE; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL LINE; CHONDROCYTES; FIBROBLAST GROWTH FACTOR 9; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION; GROWTH SUBSTANCES; MICE; MICE, TRANSGENIC; OSTEOCHONDRODYSPLASIAS; PROTEIN-TYROSINE KINASES; RATS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3; RECEPTORS, FIBROBLAST GROWTH FACTOR;

EID: 0032759872     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1999.14.11.1909     Document Type: Article

References (40)

1. Basilico C, Moscatelli D 1992 The FGF family of growth factors and oncogenes. Adv Cancer Res 59:115-165.
2. Johnson DE, Williams LT 1993 Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res 60:1-41.
3. Galzie Z, Kinsella AR, Smith JA 1997 Fibroblast growth factors and their receptors [In Process Citation]. Biochem Cell Biol 75:669-685.
4. Zetter BR 1998 Angiogenesis and tumor metastasis. Annu Rev Med 49:407-424.
5. Martin GR 1998 The roles of FGFs in the early development of vertebrate limbs. Genes Dev 12:1571-1586.
6. Naruo K, Seko C, Kuroshima K, Matsutani E, Sasada R, Kondo T, Kurokawa T 1993 Novel secretory heparin-binding factors from human glioma cells (glia-activating factors) involved in glial cell growth: Purification and biological properties. J Biol Chem 268:2857-2864.
7. Santos-Ocampo S, Colvin JS, Chellaiah A, Ornitz DM 1996 Expression and biological activity of mouse fibroblast growth factor-9. J Biol Chem 271:1726-1731.
8. Hecht D, Zimmerman N, Bedford M, Avivi A, Yayon A 1995 Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4. Growth Factors 12:223-233.
9. Yayon A, Klagsbrun M, Esko JD, Leder P, Ornitz DM 1991 Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 64:841-348.
10. Kim HJ, Rice DP, Kettunen PJ, Thesleff I 1998 FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development 125:1241-1251.
11. Webster MK, Donoghue DJ 1997 FGFR activation in skeletal disorders: Too much of a good thing. Trends Genet 13:178-182.
12. Burke D, Wilkes D, Blundell TL, Malcolm S 1998 Fibroblast growth factor receptors: Lessons from the genes. Trends Biochem Sci 23:59-62.
13. Shiang R, Thompson LM, Zhu Y-Z, Church DM, Fielder TJ, Bocian M, Winokur ST, Wasmuth JJ 1994 Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell 78:335-342.
14. Tavormina P, Shiang R, Thompson L, Zhu Y, Wilkin D, Lachman R, Wilcox W, Rimoin D, Cohn D, Wasmuth J 1995 Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3. Nat Genet 9:321-328.
15. Horton WA 1997 Fibroblast growth factor receptor 3 and the human chondrodysplasias. Curr Opin Pediatr 9:437-442.
16. Naski MC, Wang Q, Xu J, Ornitz DM 1996 Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet 13:233-237.
17. Zhou G, Garofalo S, Mukhopadhyay K, Lefebvre V, Smith CN, Eberspaecher H, de Crombrugghe B 1995 A 182 bp fragment of the mouse pro alpha 1 (II) collagen gene is sufficient to direct chondrocyte expression in transgenic mice. J Cell Sci 108:3677-3684.
18. Mukhopadhyay K, Lefebvre V, Zhou G, Garofalo S, Kimura JH, de Crombrugghe B 1995 Use of a new rat chondrosarcoma cell line to delineate a 119-base pair chondrocyte-specific enhancer element and to define active promoter segments in the mouse pro-alpha 1 (II) collagen gene. J Biol Chem 270:27711-27719.
19. Metsaranta M, Garofalo S, Smith C, Niederreither K, de Crombrugghe B, Vuorio E 1995 Developmental expression of a type II collagen/beta-galactosidase fusion gene in transgenic mice. Dev Dyn 204:202-210.
20. Peters K, Ornitz D, Werner S, Williams L 1993 Unique expression pattern of the FGF receptor 3 gene during mouse organo-genesis. Dev Biol 155:423-430.
21. Orr-Urtreger A, Givol D, Yayon A, Yarden Y, Lonai P 1991 Developmental expression of two murine fibroblast growth factor receptors, flg and bek. Development 113:1419-1434.
22. Garofalo S, Vuorio E, Metsaranta M, Rosati R, Toman D, Vaughan J, Lozano G, Mayne R, Ellard J, Horton W, et al. 1991 Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene. Proc Natl Acad Sci USA 88:9648-9652.
23. Spivak-Kroizman T, Lemmon MA, Dikic I, Ladbury JE, Pinchasi D, Huang J, Jaye M, Crumley G, Schlessinger J, Lax I 1994 Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Cell 79:1015-1024.
24. Moy FJ, Safran M, Seddon AP, Kitchen D, Bohlen P, Aviezer D, Yayon A, Powers R 1997 Properly oriented heparin-decasaccharide-induced dimers are the biologically active form of basic fibroblast growth factor [published erratum appears in Biochemistry 1997 Jun 24; 36(25):7936]. Biochemistry 36:4782-4791.
25. Li C, Chen L, Iwata T, Kitagawa M, Fu XY, Deng CX 1999 A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Hum Mol Genet 8:35-44.
26. Naski MC, Colvin JS, Coffin JD, Ornitz DM 1998 Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development 125:4977-4988.
27. Leach RM Jr, Sokol C, McMurtry JP 1997 Immunolocalization of basic fibroblast growth factor in porcine epiphyseal growth plate. Domest Anim Endocrinol 14:129-132.
28. Jingushi S, Scully SP, Joyce ME, Sugioka Y, Bolander ME 1995 Transforming growth factor-beta 1 and fibroblast growth factors in rat growth plate. J Orthop Res 13:761-768.
29. Peters KG, Werner S, Chen G, Williams LT 1992 Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. Development 114:233-243.
30. Coffin JD, Florkiewicz RZ, Neumann J, Mort-Hopkins T, Dorn GW II, Lightfoot P, German R, Howles PN, Kier A, O'Toole BA, et al. 1995 Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice. Mol Biol Cell 6:1861-1873.
31. Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M 1996 Receptor specificity of the fibroblast growth factor family. J Biol Chem 271:15292-15297.
32. Legeai-Mallet L, Benoist-Lasselin C, Delezoide AL, Munnich A, Bonaventure J 1998 Fibroblast growth factor receptor 3 mutations promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia. J Biol Chem 273:13007-13014.
33. Breur GJ, VanEnkevort BA, Farnum CE, Wilsman NJ 1991 Linear relationship between the, of hypertrophic chondrocytes and the rate of longitudinal bone growth in growth plates. J Orthopaed Res 9:348-359.
34. Breur GJ, Farnum CE, Padgett GA, Wilsman NJ 1992 Cellular basis of decreased rate of longitudinal growth of bone in pseudoachondroplastic dogs. J Bone Joint Surgery 74A:516-528.
35. Breur GJ, Turgai J, Vanenkevort BA, Farnum CE, Wilsman NJ 1994 Stereological and serial section analysis of chondrocytic enlargement in the proximal tibial growth plate of the rat. Anat Rec 239:255-268.
36. Deng C, Wynshaw-Boris A, Zhou F, Kuo A, Leder P 1996 Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84:911-921.
37. Colvin JS, Bohne BA, Harding GW, McEwen DG, Ornitz DM 1996 Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat Genet 12:390-397.
38. Su W-CS, Kitagawa M, Xue N, Xie B, Garofalo S, Cho J, Deng C, Horton WA, Fu X-Y 1997 Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature 386:288-291.
39. Di Cunto F, Topley G, Calautti E, Hsiao J, Ong L, Seth PK, Dotto GP 1998 Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control [see comments]. Science 280:1069-1072.
40. Flaumenhaft R, Moscatelli D, Rifkin DB 1990 Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor. J Cell Biol 111:1651-1659.