Hepatitis B surface antigen- And tetanus toxoid-specific clonal expansion of CD4+ cells in vitro determined by TCRBV CDR3 length and nucleotide sequence

Genes and Immunity

Volumn 2, Issue 1, 2001, Pages 11-19

  Uko, G P ^a   Fraser, P A ^a   Awdeh, Z L ^a   Fici, D A ^a   Crawford, K D ^a   Larsen, C E ^a   Alper, C A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CENTER FOR BLOOD RESEARCH   (United States)

Author keywords

CD4+ PBMC; Monoclonality oligoclonality; Recall antigen; Spectratyping

Indexed keywords

COMPLEMENTARY DNA; HEPATITIS B SURFACE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY; TETANUS TOXOID;

ARTICLE; CD4+ T LYMPHOCYTE; CELL DIVISION; COMPLEMENTARITY DETERMINING REGION; CYTOLOGY; GENETICS; HUMAN; IMMUNOLOGY; IN VITRO STUDY; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHENOTYPE; REPRODUCIBILITY;

ANTIBODIES, MONOCLONAL; BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CLONING, MOLECULAR; COMPLEMENTARITY DETERMINING REGIONS; DNA, COMPLEMENTARY; HEPATITIS B SURFACE ANTIGENS; HUMANS; MOLECULAR SEQUENCE DATA; PHENOTYPE; RECEPTORS, ANTIGEN, T-CELL; REPRODUCIBILITY OF RESULTS; TETANUS TOXOID;

EID: 0035257833     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6363729     Document Type: Article

References (25)

1. Moss PAH, Rosenberg WMC, Bell JI. The human T cell receptor in health and disease. Annu Rev Immunol 1992; 10: 71-96.
2. + T-cell repertoire that are not immediately restored by antiviral and immune-based therapies. Nat Med 1997; 3: 533-540.
3. Fraser PA, Lu LY, DeCeulaer K et al. CD4 TCRBV CDR3 analysis in prevalent SLE cases from two ethnic groups. Lupus 1999; 8: 311-319.
4. Goodall JC, Bledsoe P, Gaston JSH. Tracking antigen-specific human T lymphocytes in rheumatoid arthritis by T cell receptor analysis. Hum Immunol 1999; 60: 798-805.
5. Struyk L, Hawes GE, Chatilia MK et al. T cell receptors in rheumatoid arthritis. Arthritis Rheum 1995; 38: 577-589.
6. + subset in normal human subjects. J Immunol 1993; 151: 5762-5769.
7. + T cells and induce T cell responses to native peptide ligands. J Immunol 1999; 163: 6424-6434.
8. + T-cell population. Analysis using multiplex PCR assay for CDR3 length. Ann NY Acad Sci 1995; 756: 19-27.
9. Sundstedt A, Dohlsten M, Hedlund G et al. Superantigens anergize cytokine production but not cytotoxicity in vivo. Immunology 1994; 82: 117-125.
10. Maini MK, Casorati G, Wack A et al. T-cell clonality in immune responses. Immunol Today 1999; 20: 262-266.
11. Deulofeut H, Robinson MA. The human T cell receptor repertoire utilized in response to HBsAg. Hum Immunol 1997; 57: 54-61.
12. + T lymphocytes: in vitro life span of clonotypic T cells. J Virol 1995; 69: 8046-8050.
13. + monocytes are dendritic cells. J Immunol 1999; 163: 5920-5928.
14. Manfras BJ, Terjung D, Boehm BO. Non-productive human TCRβ chain genes represent V-D-J diversity before selection upon function: insight into biased usage of TCRBD and TCRBJ genes and diversity of CDR3 region length. Hum Immunol 1999; 60: 1090-1100.
15. Yassai M, Newton-Nash D, Gorski J. Bacterial toxin superantigens stimulate all members of susceptible VB gene families. Ann NY Acad Sci 1995; 756: 110-112.
16. Larsen CE, Xu J, Lee S et al. Complex cytokine responses to hepatitis B surface antigen and tetanus toxoid in responders, nonresponders and subjects naive to hepatitis B surface antigen. Vaccine 2000; 18: 3021-3030.
17. Yuh K, Sugyo S, Nakamura K et al. Analysis of human T-cell antigen receptor variable β gene usage following vaccination with recombinant HBsAg. Digest Dis Sci 1998; 43: 880-886.
18. Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunol 1995; 13: 29-60.
19. + population. Immunology 1998; 94: 529-535.
20. Bäckström BT, Müller U, Hausmann B et al. Positive selection through a motif in the αβ T cell receptor. Science 1998; 281: 835-838.
21. Salazar M, Deulofeut H, Granja C et al. Normal HBsAg presentation and T-cell defect in the immune response of nonresponders. Immunogenetics 1995; 41: 366-374.
22. Desombere I, Hauser P, Rossau R et al. Nonresponders to hepatitis B vaccine can present envelope particles to T lymphocytes. J Immunol 1995; 154: 520-529.
23. Sasaki M, Nakamura S, Ohyama Y et al. Accumulation of common T cell clonotypes in the salivary glands of patients with human T lymphotropic virus type I-associated and idiopathic Sjögren's syndrome. J Immunol 2000; 164: 2823-2831.
24. Posnett DN. Environmental and genetic factors shape the human T-cell receptor repertoire. Ann NY Acad Sci 1995; 756: 71-80.
25. Kruskall MS, Alper CA, Awdeh Z et al. The immune response to hepatitis B vaccine in humans: inheritance patterns in families. J Exp Med 1992; 175: 495-502.