Replicative helicases can translocate through abasic site-induced covalent topoisomerase IV-DNA complexes

Nucleic Acids Research

Volumn 29, Issue 3, 2001, Pages 614-621

  Shea, M E ^a   Hiasa, H ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA TOPOISOMERASE INHIBITOR; DNA TOPOISOMERASE IV; EDETIC ACID; HELICASE; POISON; PROTEIN; QUINOLONE; SODIUM CHLORIDE;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; DNA DAMAGE; DNA DRUG COMPLEX; DNA REPLICATION; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME LOCALIZATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; STIMULATION;

EID: 0035253613     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.3.614     Document Type: Article

References (23)

1. DNA topoisomerases
2. DNA gyrase: An enzyme that introduces superhelical turns into DNA
3. Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme
4. Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity
5. Escherichia coli mutants thermosensitive for deoxyribonucleic acid gyrase subunit A: Effects on deoxyribonucleic acid replication, transcription and bacteriophage growth
6. The molecular basis of quinolone action
7. DNA topoisomerases: Essential enzymes and lethal targets
8. Topoisomerase poisons: Harnessing the dark side of enzyme mechanism
9. DNA gyrase and topoisomerase IV on the bacterial chromosome: Quinolone-induced DNA cleavage
10. Adriamycin-induced DNA damage is mediated by mammalian DNA topoisomerase II
11. The involvement of topoisomerase I in the induction of DNA-protein crosslinks and DNA single-strand breaks in cells of ultraviolet-irradiated human and frog cell lines
12. Human DNA topoisomerase I-mediated cleavages stimulated by ultraviolet light-induced DNA damage
13. Effects of uracil incorporation, DNA mismaches and abasic sites on cleavage and religation activities of mammalian topoisomerase I
14. Abasic sites stimulate double-stranded DNA cleavage mediated by topoisomerase II
15. Apurinic sites are position specific topoisomerase II poisons
16. Spontaneous DNA damage stimulates topoisomerase II-mediated DNA cleavage
17. DNA abasic lesions in a different light: Solution structure of an endogeneous topoisomerase II poison
18. Interactions between DNA helicases and frozen topoisomerase IV-quinolone-DNA ternary complexes
19. Escherichia coli topoisomerase IV: Purification, characterization, subunit structure and subunit interactions
20. Mechanism of quinolone action: A drug-induced structural perturbation of the DNA precedes strand cleavage by topoisomerase IV
21. DNA strand cleavage is required for replication fork arrest by a frozen topoisomerase-quinolone-DNA ternary complex
22. Structure and function of the multifunctional DNA-repair enzyme exonuclease III
23. DNA gyrase-mediated wrapping of the DNA strand is required for the replication fork arrest by the DNA gyrase-quinolone-DNA ternary complex