Overexpression of a slit homologue impairs convergent extension of the mesoderm and causes cyclopia in embryonic zebrafish

Developmental Biology

Volumn 230, Issue 1, 2001, Pages 1-17

  Yeo, S Y ^a   Little, M H ^a   Yamada, T ^a   Miyashita, T ^a   Halloran, M C ^a   Kuwada, J Y ^a   Huh, T L ^a   Okamoto, H ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Convergent extension; Cyclopia; Floor plate; Mesoderm; Slit; Zebrafish

Indexed keywords

COMPLEMENTARY DNA; DNA FRAGMENT; HEAT SHOCK PROTEIN; LIGAND; MESSENGER RNA;

ARTICLE; CELL MIGRATION; CYCLOPIA; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; GASTRULATION; GROWTH CONE; MESODERM; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; ZEBRA FISH;

CYCLOPIA; DANIO RERIO; DROSOPHILA; INVERTEBRATA; VERTEBRATA;

EID: 0035253450     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2000.0105     Document Type: Article

References (75)

1. Combinatorial expression of three zebrafish genes related to distal-less: Part of a homeobox gene code for the head
2. Basic local alignment search tool
3. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polariy and Wingless signaling pathways
4. Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundbout receptor
5. Negative regulation of fibroblast motility by Ena/VASP proteins
6. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance
7. Development of branchiomotor neurons in zebrafish
8. Embryonic expression and extracellular secretion of. Xenopus Slit
9. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
10. Axonogenesis in the brain of zebrafish embryos
11. Differential patterning of ventral midline cells by axial mesoderm is regulated by BMP7 and chordin
12. Patterning activities of vertebrate hedgehog proteins in the developing eye and brain
13. Zebrafish organizer development and germ-layer formation require nodal-related signals
14. Expression of the zebrafish gene hlx-1 in the prechordal plate and during CNS development
15. Determination of the zebrafish forebrain: Induction and patterning
16. Laser-induced gene expression in specific cells of transgenic zebrafish
17. The cyclops mutation blocks specification of the floorplate of the zebrafish central nervous system
18. Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
19. Mindin/F-spondin family: Novel ECM proteins expressed in the zebrafish embryonic axis
20. Visualization of cranial motor neurons in live transgenic zebrafish expressing green fluorescent protein under the control of the islet-1 promoter/enhancer
21. Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis
22. Chemorepulsion of neuronal migration by Slit2 in the developing mammalian forebrain
23. Developmental regulation of islet-1 mRNA expressing during neuronal differentiation in embryonic zebrafish
24. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system
25. Mediolateral cell intercalation in the dorsal, axial mesoderm of Xenopus laevis
26. Cell intercalation during notochord development in Xenopus laevis
27. The patterning and functioning of protrusive activity during convergence and extension of the Xenopus organiser
28. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
29. Slit is the midline repellent for the Robo receptor in Drosophila
30. Dosagesensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline
31. Ocular and cerebellar defects in zebrafish induced by overexpression of the LIM domains of the islet-3 LIM/homeodomain protein
32. Characterization of two frizzled 8 homologues expressed in the embryonic shield and prechordal plate of zebrafish embryos
33. Stages of embryonic development of the zebrafish
34. The leucine-rich repeat: A versatile binding motif
35. A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
36. Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis
37. Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons
38. A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate
39. Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan Glypican-1 in brain
40. Orchestral maneuvers in the axon: Trio and the control of axon guidance
41. Midline signalling is required for Pax gene regulation and patterning of the eyes
42. Putting on the brakes: A negative regulatory function for Ena/VASP proteins in cell migration
43. Functional interactions of genes mediating convergent extension, knypek and trilobite, during the partitioning of the eye primordium in zebrafish
44. Wnt signaling: Moving in a new direction
45. Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons
46. Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening
47. The development and function of the Drosophila CNS midline cells
48. Methods for computing the standard errors of branching points in an evolutionary tree and their application to molecular data from humans and apes
49. Slit2-mediated chemorepulsion and collapse of developing forebrain axons
50. Porcine submaxillary mucin forms disulfied-bonded dimers between its carboxyl-terminal domains
51. Cyclops encodes a nodal-related factor involved in midline signaling
52. Specific EGF repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multifunctional receptor
53. Modularity of the Slit protein. Characterization of a conserved carboxy-terminal sequence in secreted proteins and a motif implicated in extracellular protein interactions
54. slit: An extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains
55. slit: An EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system
56. Xenopus embryos regulate the nuclear localization of XmyoD
57. Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling
58. The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail
59. The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo
60. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system
61. Cell motility driving mediolateral intercalation in explants of Xenopus laevis
62. Patterns of cell motility in the organizer and dorsal mesoderm of Xenopus laevis
63. Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish
64. Commissureless controls growth cone guidance across the CNS midline in Drosophila and encodes a novel membrane protein
65. Expression of achaetescute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate
66. Anterior movement of ventral diencephalic precursors separates the primordial eye field in the neural plate and requires cyclops
67. Biochemical purification of mammalian slit protein as a positive regulator of sensory axon elongation and branching
68. Cell movements during epiboly and gastrulation in zebrafish
69. The development of a simple scaffold of axon tracts in the brain of the embryonic zebrafish Brachydanio rerio
70. Order and coherence in the fate map of the zebrafish nervous system
71. Directional guidance of neuronal migration in the olfactory system by the protein Slit
72. The mouse SLIT family: Secreted ligand for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance
73. Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex