The anti-herpesvirus activity of (1′S,2′R)-9-[[1′,2′-bis(hydroxymethyl) cycloprop-1′-y1]methyl]guanine is markedly potentiated by the immunosuppressive agent mycophenolate mofetil

Antiviral Research

Volumn 49, Issue 2, 2001, Pages 121-127

  Neyts, Johan ^a   Clercq, Erik De ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

9 [1,2 BIS(HYDROXYMETHYL)CYCLOPROPYLMETHYL]GUANINE; ANTIVIRUS AGENT; DEOXYGUANOSINE TRIPHOSPHATE; DNA POLYMERASE; DRUG METABOLITE; MYCOPHENOLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVITY; HERPES; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; IMMUNOSUPPRESSIVE TREATMENT; INFECTION RESISTANCE; METABOLITE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; TRANSPLANTATION;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CERCOPITHECUS AETHIOPS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; GUANINE; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HUMANS; MICE; MICE, INBRED HRS; MICROBIAL SENSITIVITY TESTS; MYCOPHENOLIC ACID; VERO CELLS;

HERPESVIRIDAE; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2;

EID: 0035251014     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(00)00145-5     Document Type: Article

References (13)

1. Ribavirin antagonizes inhibitory effects of pyrimidine 2′,3′-dideoxynucleosides but enhances inhibitory effects of purine 2′,3′-dideoxynucleosides on replication of human immunodeficiency virus in vitro
2. Clinical pharmacokinetics of mycophenolate
3. Mycophenolate mofetil. A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in renal transplantation
4. Avoidance of bone marrow suppression using A-5021 as a nucleoside analog for retrovirus-mediated herpes simplex virus type I thymidine kinase gene therapy
5. Antiherpesvirus activities of (1′S,2′R)-9-[[1′,2′-bis(hydroxymethyl) cycloprop-1′-yl]methyl]guanine (A-5021) in cell culture
6. Evaluation of anti-herpesvirus activity of (1′S,2′R)-9-[[1′,2′-bis(hydroxymethyl) cycloprop-1′-y1]methyl]-guanine (A-5021) in mice
7. Mycophenolate mofetil strongly potentiates the anti-herpesvirus activity of acyclovir
8. The immunosuppressive agent mycophenolate mofetil markedly potentiates the activity of lobucavir [1R(1alpha,2beta,3alpha)]-9-[2,3-bis(hydroxymethyl) cyclobutyl]guanine against different herpes viruses
9. The novel immunosuppressive agent mycophenolate mofetil markedly potentiates the antiherpesvirus activities of acyclovir, ganciclovir and penciclovir in vitro and in vivo
10. The antiherpesvirus activity of H2G [(R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine] is markedly enhanced by the immunosuppressive agent mycophenolate mofetil
11. Anti-herpes virus activity of (1′S,2′R)-9-[[1′,2′-bis(hydroxymethyl) cycloprop-1′-y1]methyl]guanine (A-5021) in vitro and in vivo
12. Mode of action of (1′S,2′R)-9-[[1′,2′-bis(hydroxymethyl) cycloprop-1′-y1]methyl]guanine (A-5021) against herpes simplex virus type 1 and type 2 and varicella-zoster virus
13. Synthesis and antiviral activity of novel acyclic nucleosides: Discovery of a cyclopropyl nucleoside with potent inhibitory activity against herpesviruses