Hepatocyte growth factor: Clinical implications in hepatobiliary pancreatic surgery

Journal of Hepato-Biliary-Pancreatic Surgery

Volumn 8, Issue 1, 2001, Pages 65-75

  Kaido, Toshimi ^a   Imamura, Masayuki ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Clinical application; Fibrosis; Hepatocyte growth factor; Liver regeneration; Transplantation

Indexed keywords

SCATTER FACTOR;

ARTIFICIAL EMBOLISM; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER; LIVER DISEASE; LIVER REGENERATION; LIVER TUMOR; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

EMBOLIZATION, THERAPEUTIC; HEPATOCYTE GROWTH FACTOR; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; LIVER DISEASES; LIVER NEOPLASMS; LIVER REGENERATION;

EID: 0035221670     PISSN: 09441166     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005340170052     Document Type: Article

References (101)

1. Gohda E, Tsubouchi H, Nakayama H, Hirono S, Takahashi K, Koura M, Hashimoto S, Daikuhara Y (1986) Human hepatocyte growth factor in plasma from patients with fulminant hepatic failure. Exp Cell Res 166:139-150
2. Nakamura T, Nawa K, Ichihara A, Kaise N, Nishino T (1987) Purification and subunit structure of hepatocyte growth factor from rat platelets. FEBS Lett 224:311-316
3. Noji S, Tashiro K, Koyama E, Nohno T, Ohyama K, Taniguchi S, Nakamura T (1990) Expression of hepatocyte growth factor gene in endothelial and Kupffer cells of damaged rat livers, as revealed by in situ hybridization. Biochem Biophys Res Commun 173:42-47
4. Ramadori G, Neubauer K, Odenthal M, Nakamura T, Knittel T, Schwogler S, Meyer zum Buschenfelde KH (1992) The gene of hepatocyte growth factor is expressed in fat-storing cells of rat liver and is downregulated during cell growth and by transforming growth factor-beta. Biochem Biophys Res Commun 183:739-742
5. Zarnegar R, Muga S, Rahija R, Michalopoulos G (1990) Tissue distribution of hepatopoietin-A: a heparin-binding polypeptide growth factor for hepatocytes. Proc Natl Acad Sci USA 87:1252-1256
6. Tsuda H, Iwase T, Matsumoto K, Ito M, Hirono I, Nishida Y, Yamamoto M, Tatematsu M, Matsumoto K, Nakamura T (1992) Immunohistochemical localization of hepatocyte growth factor protein in pancreas islet A-cells of man and rats. Jpn J Cancer Res 83:1262-1266
7. Furukawa T, Duguid WP, Kobari M, Matsuno S, Tsao MS (1995) Hepatocyte growth factor and Met receptor expression in human pancreatic carcinogenesis. Am J Pathol 147:889-895
8. Lokker NA, Mark MR, Luis EA, Bennett GL, Robbins KA, Baker JB, Godowski PJ (1992) Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding. EMBO J 11:2503-2510
9. Naka D, Ishii T, Yoshiyama Y, Miyazawa K, Hara H, Hishida T, Kidamura N (1992) Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer. J Biol Chem 267:20114-20119
10. Naldini L, Tamagnone L, Vigna E, Sachs M, Hartmann G, Birchmeier W, Daikuhara Y, Tsubouchi H, Blasi F, Comoglio PM (1992) Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J 11:4825-4833
11. Nakamura T, Nishizawa T, Hagiya M, Seki T, Shimonishi M, Sugimura A, Tashiro K, Shimizu S (1989) Molecular cloning and expression of human hepatocyte growth factor. Nature 342:440-443
12. Gohda E, Tsubouchi H, Nakayama H, Hirono S, Sakiyama O, Takahashi K, Miyazaki H, Hashimoto S, Daikuhara Y (1988) Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure. J Clin Invest 81:414-419
13. Zarnegar R, Michalopoulos G (1989) Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes. Cancer Res 49:3314-3320
14. Shimomura T, Miyazawa K, Komiyama Y, Hiraoka H, Naka D, Morimoto Y, Kitamura N (1995) Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator. Eur J Biochem 229:257-261
15. Mars WM, Zarnegar R, Michalopoulos GK (1993) Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA. Am J Pathol 143:949-958
16. Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N (1993) Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII. J Biol Chem 268:10024-10028
17. Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N (1993) Activation of the zymogen of hepatocyte growth factor activator by thrombin. J Biol Chem 268:22927-22932
18. Kawaguchi T, Qin L, Shimomura T, Kondo J, Matsumoto K, Denda K, Kitamura N (1997) Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor. J Biol Chem 272:27558-27564
19. Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N (1997) Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. J Biol Chem 272:6370-6376
20. Matsumoto K, Tajima H, Hamanoue M, Kohno S, Kinoshita T, Nakamura T (1992) Identification and characterization of "injurin," an inducer of expression of the gene for hepatocyte growth factor. Proc Natl Acad Sci USA 89:3800-3804
21. Matsumoto K, Okazaki H, Nakamura T (1992) Up-regulation of hepatocyte growth factor gene expression by interleukin-1 in human skin fibroblasts. Biochem Biophys Res Commun 188:235-243
22. Tamura M, Arakaki N, Tsubouchi H, Takada H, Daikuhara Y (1993) Enhancement of human hepatocyte growth factor production by interleukin-1 alpha and -1 beta and tumor necrosis factor-alpha by fibroblasts in culture. J Biol Chem 268:8140-8145
23. Matsumoto K, Tajima H, Okazaki H, Nakamura T (1993) Heparin as an inducer of hepatocyte growth factor. J Biochem Tokyo 114:820-826
24. Gohda E, Matsunaga T, Kataoka H, Takebe T, Yamamoto I (1994) Induction of hepatocyte growth factor in human skin fibroblasts by epidermal growth factor, platelet-derived growth factor and fibroblast growth factor. Cytokine 6:633-640
25. Gohda H, Kataoka H, Tsubouchi H, Daikilara Y, Yamamoto I (1992) Phorbol ester-induced secretion of human hepatocyte growth factor by human skin fibroblasts and its inhibition by dexamethasone. FEBS Lett 301:107-110
26. Matsunaga T, Gohda E, Takebe T, Wu YL, Iwao M, Kataoka H, Yamamoto I (1994) Expression of hepatocyte growth factor is up-regulated through activation of a cAMP-mediated pathway. Exp Cell Res 210:326-335
27. Gohda E, Matsunaga T, Kataoka H, Yamamoto I (1992) TGF-beta is a potent inhibitor of hepatocyte growth factor secretion by human fibroblasts. Cell Biol Int Rep 16:917-926
28. Okajima A, Miyazawa K, Kitamura N (1993) Characterization of the promoter region of the rat hepatocyte-growth-factor/ scatter-factor gene. Eur J Biochem 213:113-119
29. Matsumoto K, Tajima H, Okazaki H, Nakamura T (1992) Negative regulation of hepatocyte growth factor gene expression in human lung fibroblasts and leukemic cells by transforming growth factor-beta 1 and glucocorticoids. J Biol Chem 267: 24917-24920
30. Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA (1991) Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 251:802-804
31. Naldini L, Vigna E, Narsimhan RP, Gaudino G, Zarnegar R, Michalopoulos GK, Comoglio PM (1991) Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene 6:501-504
32. Park M, Dean M, Kaul K, Braun MJ, Gonda MA, Vande Woude G (1987) Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors. Proc Natl Acad Sci USA 84:6379-6383
33. Ponzetto C, Bardelli A, Zhen Z, Maina F, dalla Zonca P, Giordano S, Graziani A, Panayotou G, Comoglio PM (1994) A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 77:261-271
34. Comoglio PM, Boccaccio C (1996) The HGF receptor family: unconventional signal transducers for invasive cell growth. Genes Cells 1:347-354
35. Webb CP, Lane K, Dawson AP, Vande Woude GF, Warn RM (1996) C-Met signalling in an HGF/SF-insensitive variant MDCK cell line with constitutive motile/invasive behaviour. J Cell Sci 109:2371-2381
36. Miyazawa K, Tsubouchi H, Naka D, Takahashi K, Okigaki M, Arakaki N, Nakayama H, Hirono S, Sakiyama O, Takahashi K, Gohda E, Daikuhara Y, Kitamura N (1989) Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor. Biochem Biophys Res Commun 163:967-973
37. Liu Z, Sakamoto T, Ezure T, Yokomuro S, Murase N, Michalopoulos G, Demetris AJ (1998) Interleukin-6, hepatocyte growth factor, and their receptors in biliary epithelial cells during a type I ductular reaction in mice: interactions between the periductal inflammatory and stromal cells and the biliary epithelium. Hepatology 28:1260-1268
38. Otonkoski T, Cirulli V, Beattie M, Mally MI, Soto G, Rubin JS, Hayek A (1996) A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth. Endocrinology 137:3131-3139
39. Gherardi E, Gray J, Stoker M, Perryman M, Furlong R (1989) Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement. Proc Natl Acad Sci USA 86:5844-5848
40. Weidner KM, Arakaki N, Hartmann G, Vandekerckhove J, Weingart S, Rieder H, Fonatsch C, Tsubouchi H, Hishida T, Daikuhara Y, Birchmeier W (1991) Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc Natl Acad Sci USA 88:7001-7005
41. Montesano R, Matsumoto K, Nakamura T, Orci L (1991) Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell 67:901-908
42. Bussolino F, Di Renzo MF, Ziche M, Bocchietto E, Olivero M, Naldini L, Gaudino G, Tamagnone L, Coffer A, Comoglio PM (1992) Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 119:629-641
43. Schmidt C, Bladt F, Goedecke S, Brinkmann V, Zschiesche W, Sharpe M, Gherardi E, Birchmeier C (1995) Scatter factor/ hepatocyte growth factor is essential for liver development. Nature 373:699-702
44. Watanabe S, Hirose M, Wang XE, Maehiro K, Murai T, Kobayashi O, Nagahara A, Sato N (1994) Hepatocyte growth factor accelerates the wound repair of cultured gastric mucosal cells. Biochem Biophys Res Commun 199:1453-1460
45. Yamaoka M, Hirata K, Ogata I, Tomiya T, Nagoshi S, Mochida S, Fujiwara K (1998) Enhancement of albumin production by hepatocyte growth factor in rat hepatocytes: distinction in mode of action from stimulation of DNA synthesis. Liver 18:52-59
46. Fujiwara K, Nagoshi S, Ohno A, Hirata K, Ohta Y, Mochida S, Tomiya T, Higashio K, Kurokawa K (1993) Stimulation of liver growth by exogenous human hepatocyte growth factor in normal and partially hepatectomized rats. Hepatology 18:1443-1449
47. Ishii T, Sato M, Sudo K, Suzuki M, Nakai H, Hishida T, Niwa T, Umezu K, Yuasa S (1995) Hepatocyte growth factor stimulates liver regeneration and elevates blood protein level in normal and partially hepatectomized rats. J Biochem Tokyo 117:1105-1112
48. Webber EM, Godowski PJ, Fausto N (1994) In vivo response of hepatocytes to growth factors requires an initial priming stimulus. Hepatology 19:489-497
49. Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Poli V, Taub R (1996) Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274:1379-1383
50. Webber EM, Bruix J, Pierce RH, Fausto N (1998) Tumor necrosis factor primes hepatocytes for DNA replication in the rat. Hepatology 28:1226-1234
51. Yamada Y, Webber EM, Kirillova I, Peschon JJ, Fausto N (1998) Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor. Hepatology 28:959-970
52. FitzGerald MJ, Webber EM, Donovan JR, Fausto N (1995) Rapid DNA binding by nuclear factor kappa B in hepatocytes at the start of liver regeneration. Cell Growth Differ 6:417-427
53. Yoshikawa A, Kaido T, Seto S, Yamaoka S, Imamura M (1998) Hepatocyte growth factor promotes liver regeneration with prompt improvement of hyperbilirubinemia in hepatectomized cholestatic rats. J Surg Res 78:54-59
54. Kaido T, Seto S, Yamaoka S, Yoshikawa A, Imamura M (1998) Perioperative continuous hepatocyte growth factor supply prevents postoperative liver failure in rats with liver cirrhosis. J Surg Res 74:173-178
55. Kinoshita H, Sakai K, Hirohashi K, Igawa S, Yamasaki O, Kubo S (1986) Preoperative portal vein embolization for hepatocellular carcinoma. World J Surg 10:803-808
56. Makuuchi M, Thai BL, Takayasu K, Takayama T, Kosuge T, Gunven P, Yamazaki S, Hasegawa H, Ozaki H (1990) Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report. Surgery 107:521-527
57. Kawasaki S, Makuuchi M, Kakazu T, Miyagawa S, Takayama T, Kosuge T, Sugihara K, Moriya Y (1994) Resection for multiple metastatic liver tumors after portal embolization. Surgery 115:674-677
58. Baere T, Roche A, Elias D, Lasser P, Lagrance C, Bousson V (1996) Preoperative portal vein embolization for extension of hepatectomy indications. Hepatology 24:1386-1391
59. Kaido T, Yoshikawa A, Seto S, Yamaoka S, Sato M, Ishii T, Imamura M (1998) Portal branch ligation with a continuous hepatocyte growth factor supply makes extensive hepatectomy possible in cirrhotic rats. Hepatology 28:756-760
60. Ishiki Y, Ohnishi H, Muto Y, Matsumoto K, Nakamura T (1992) Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent anti-hepatitis effect in vivo. Hepatology 16:1227-1235
61. Miyazawa K, Shimomura T, Kitamura N (1996) Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator. J Biol Chem 271:3615-3618
62. Miyazawa K, Shimomura T, Naka D, Kitamura N (1994) Proteolytic activation of hepatocyte growth factor in response to tissue injury. J Biol Chem 269:8966-8970
63. Matsuda Y, Matsumoto K, Ichida T, Nakamura T (1995) Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats. J Biochem Tokyo 118:643-649
64. Yasuda H, Imai E, Shiota A, Fujise N, Morinaga T, Higashio K (1996) Antifibrotic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats. Hepatology 24:636-642
65. Yoshida H, Shiratori Y, Moriyama M, Arakawa Y, Ide T, Sata M, Inoue O, Yano M, Tanaka M, Fujiyama S, Nishiguchi S, Kuroki T, Imazeki F, Yokosuka O, Kinoyama S, Yamada G, Omata M (1999) Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Inhibition of hepatocarcinogenesis by interferon therapy. Ann Intern Med 131:174-181
66. Yamashita K, Matsuoka H, Ochiai T, Matsushita R, Kubuki Y, Suzuki M, Tsubouchi H (2000) Hepatocyte growth factor/scatter factor enhances the thrombopoietin mRNA expression in rat hepatocytes and cirrhotic rat livers. J Gastroenterol Hepatol 15:83-90
67. Kaido T, Yamaoka S, Tanaka J, Seto S, Funaki N, Kasamatsu T, Nakamura T, Imamura M (1996) Continuous HGF supply from HGF-expressing fibroblasts transplanted into spleen prevents CC14-induced acute liver injury in rats. Biochem Biophys Res Commun 218:1-5
68. Kaido T, Yamaoka S, Seto S, Tanaka J, Funaki N, Nakamura T, Imamura M (1997) Continuous hepatocyte growth factor supply prevents lipopolysaccharide-induced liver injury in rats. FEBS Lett 411:378-382
69. Seto S, Kaido T, Yamaoka S, Yoshikawa A, Arii S, Nakamura T, Niwano M, Imamura M (1998) Hepatocyte growth factor prevents lipopolysaccharide-induced hepatic sinusoidal endothelial cell injury and intrasinusoidal fibrin deposition in rats. J Surg Res 80:194-199
70. Kosai K, Matsumoto K, Funakoshi H, Nakamura T (1999) Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice. Hepatology 30:151-159
71. Okano J, Shiota G, Kawasaki H (1997) Protective action of hepatocyte growth factor for acute liver injury caused by D-galactosamine in transgenic mice. Hepatology 26:1241-1249
72. Kosai K, Matsumoto K, Nagata S, Tsujimoto Y, Nakamura T (1998) Abrogation of Fas-induced fulminant hepatic failure in mice by hepatocyte growth factor. Biochem Biophys Res Commun 244:683-690
73. Kondo H, Tani T, Kodama M (1999) Effects of deletion-type human hepatocyte growth factor on murine septic model. J Surg Res 85:88-95
74. Kaido T, Yoshikawa A, Seto S, Yamaoka S, Furuyama H, Arii S, Takahashi Y, Imamura M (1999) Pretreatment with soluble thrombomodulin prevents intrasinusoidal coagulation and liver dysfunction following extensive hepatectomy in cirrhotic rats. Thromb Haemost 82:1302-1306
75. Ueki T, Kaneda Y, Tsutsui H, Nakanishi K, Sawa Y, Morishita R, Matsumoto K, Nakamura T, Takahashi H, Okamoto E, Fujimoto J (1999) Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Nat Med 5:226-230
76. Todo S, Nery J, Yanaga K, Podesta L, Gordon RD, Starzl TE (1989) Extended preservation of human liver grafts with UW solution. JAMA 261:711-714
77. Urena MA, Moreno Gonzalez E, Romero CJ, Ruiz-Delgado FC, Moreno Sanz C (1999) An approach to the rational use of steatotic donor livers in liver transplantation. Hepatogastroenterology 46:1164-1173
78. Nakano H, Nagasaki H, Barama A, Boudjema K, Jaeck D, Kumada K, Tatsuno M, Baek Y, Kitamura N, Suzuki T, Yamaguchi M (1997) The effects of N-acetylcysteine and anti-intercellular adhesion molecule-1 monoclonal antibody against ischemia-reperfusion injury of the rat steatotic liver produced by a choline-methionine-deficient diet. Hepatology 26:670-678
79. Takeda Y, Arii S, Kaido T, Niwano M, Moriga T, Mori A, Hanaki K, Gorrin-Rivas MJ, Ishii T, Sato M, Imamura M (1999) Morphologic alteration of hepatocytes and sinusoidal endothelial cells in rat fatty liver during cold preservation and the protective effect of hepatocyte growth factor. Transplantation 67: 820-828
80. Uchiyama H, Yanaga K, Nishizaki T, Soejima Y, Yoshizumi T, Sugimachi K (1999) Effects of deletion variant of hepatocyte growth factor on reduced-size liver transplantation in rats. Transplantation 68:39-44
81. Ikegami T, Nishizaki T, Uchiyama H, Kakizoe S, Yanaga K, Sugimachi K (1999) Deletion variant of hepatocyte growth factor prolongs allograft survival after liver transplantation in rats. Surgery 125:602-607
82. Kato K, Onodera K, Sawa M, Imai M, Kawahara T, Kasai S, Mito M (1996) Effect of hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes in rats. Biochem Biophys Res Commun 222:101-106
83. Yamaguchi Y, Hamaguchi H, Yamada S, Fujiwara K, Higashio K, Miyanari N, Ichiguchi O, Goto M, Mori K, Ogawa M (1997) Recombinant human hepatocyte growth factor facilitates biliary transport after hepatocyte transplantation in Eisai hyperbilirubinemic rats. Dig Dis Sci 42:522-528
84. Tajima H, Matsumoto K, Nakamura T (1991) Hepatocyte growth factor has potent anti-proliferative activity in various tumor cell lines. FEBS Lett 291:229-232
85. Shiota G, Rhoads DR, Wang TC, Nakamura T, Schmidt EV (1992) Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. Proc Natl Acad Sci USA 89:373-377
86. Shiota G, Wang TC, Nakamura T, Schmidt EV (1994) Hepatocyte growth factor in transgenic mice: effects on hepatocyte growth, liver regeneration and gene expression. Hepatology 19:962-972
87. Santoni-Rugiu E, Preisegger KH, Kiss A, Audolfsson T, Shiota G, Schmidt EV, Thorgeirsson SS (1996) Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model. Proc Natl Acad Sci USA 93:9577-9582
88. Miyazaki M, Gohda E, Tsuboi S, Tsubouchi H, Daikuhara Y, Namba M, Yamamoto I (1992) Human hepatocyte growth factor stimulates the growth of HUH-6 clone 5 human hepatoblastoma cells. Cell Biol Int Rep 16:145-154
89. Sakata H, Takayama H, Sharp R, Rubin JS, Merlino G, LaRochelle WJ (1996) Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers. Cell Growth Differ 7:1513-1523
90. Yaono M, Hasegawa R, Mizoguchi Y, Futakuchi M, Nakamura T, Ito N, Shirai T (1995) Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res 86:718-723
91. Ogasawara H, Hiramoto J, Takahashi M, Shirahama K, Furusaka A, Hiyane S, Nakada T, Nagayama K, Tanaka T (1998) Hepatocyte growth factor stimulates DNA synthesis in rat preneoplastic hepatocytes but not in liver carcinoma cells. Gastroenterology 114:775-781
92. Date K, Matsumoto K, Kuba K, Shimura H, Tanaka M, Nakamura T (1998) Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor. Oncogene 17:3045-3054
93. Ueki T, Fujimoto J, Suzuki T, Yamamoto H, Okamoto E (1997) Expression of hepatocyte growth factor and its receptor c-met proto-oncogene in hepatocellular carcinoma. Hepatology 25:862-866
94. Kimura F, Miyazaki M, Suwa T, Sugiura T, Shinoda T, Itoh H, Ambiru S, Shimizu H, Nakagawa K (2000) Plasma human hepatocyte growth factor concentrations in patients with biliary obstruction. J Gastroenterol Hepatol 15:76-82
95. Higaki I, Yamazaki O, Matsuyama M, Horii K, Kawai S, Tsukamoto T, Tanaka H, Kubo S, Hirohashi K, Kinoshita H (1999) Serum endothelin-1 and hepatocyte growth factor levels in patients with obstructive jaundice. Hepatogastroenterology 46:1599-1602
96. Takeuchi E, Nimura Y, Nagino M, Kurumiya Y, Maeda A, Kamiya J, Kondo S, Kanai M, Miyachi M, Uesaka K, Yoshida S (1997) Human hepatocyte growth factor in bile: an indicator of posthepatectomy liver function in patients with biliary tract carcinoma. Hepatology 26:1092-1099
97. Otonkoski T, Beattie GM, Rubin JS, Lopez AD, Baird A, Hayck A (1994) Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells. Diabetes 43:947-953
98. Hayek A, Beattie GM, Cirulli V, Lopez AD, Ricordi C, Rubin JS (1995) Growth factor/matrix-induced proliferation of human adult beta-cells. Diabetes 44:1458-1460
99. Otonkoski T, Mally MI, Hayek A (1994) Opposite effects of beta-cell differentiation and growth on reg expression in human fetal pancreatic cells. Diabetes 43:1164-1166
100. Nakano M, Yasunami Y, Maki T, Kodama S, Ikehara Y, Nakamura T, Tanaka M, Ikeda S (2000) Hepatocyte growth factor is essential for amelioration of hyperglycemia in streptozotocin-induced diabetic mice receiving a marginal mass of intrahepatic islet grafts. Transplantation 69:214-221
101. Garcia-Ocana A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF (2000) Hepatocyte growth factor overexpression in the islets of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem 275:1226-1232