A novel insulinoma tumor suppressor gene locus on chromosome 22q with potential prognostic implications

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 12, 2001, Pages 5782-5787

  Wild, A ^a   Langer, P ^a   Ramaswamy, A ^a   Chaloupka, B ^a   Bartsch, D K ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MICROSATELLITE DNA; RNA;

ADULT; AGED; ARTICLE; CHROMOSOME 22Q; CLINICAL ARTICLE; DNA SEQUENCE; EXPRESSED SEQUENCE TAG; GENE DELETION; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC MARKER; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; INSULINOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROGNOSIS; RNA ANALYSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

EID: 0035217078     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.86.12.8089     Document Type: Article

References (43)

1. Pancreatic endocrine tumors in man
2. Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas
3. Mutation of the MENIN gene in sporadic pancreatic endocrine tumors
4. Genetic alterations on 3p, 11q13, and 18q in nonfamilial and MEN1-associated pancreatic endocrine tumors
5. Comparison of mutations of ras oncogene in human pancreatic exocrine and endocrine tumors
6. Ras mutations in endocrine tumors: Mutation detection by polymerase chain reaction-single strand conformation polymorphism
7. Molecular genetics of malignant insulinoma
8. Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors
9. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinomas
10. INK4a alterations in gastrinomas and non-functioning islet cell carcinomas
11. Abrogation of the Rb/16 tumor-supressive pathway in virtually all pancreatic carcinomas
12. INK4a-alterations in insulinomas
13. Localization of putative tumor suppressor loci by genomewide allelotyping in human pancreatic endocrine tumors
14. Allelotype of breast cancer: Cumulative allele losses promote tumor progression in primary breast cancer
15. A region of deletion on chromosome 22q13 is common to human breast and colorectal cancers
16. Localization of an ovarian cancer tumor suppressor gene to a 0.5-cM region between D22S284 and CYP2D, on chromosome 22q
17. Common regions of deletion on chromosome 22q12.3-q13.1 and 22q13.2 in human astrocytomas appear related to malignancy grade
18. Neurofibromatosis 2: Loss of Merlin's protective spell
19. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer
20. Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system
21. High-affinity monomeric 67-kD laminin receptors and prognosis in pancreatic endocrine tumors
22. Functioning human insulinomas: An immunohistochemical analysis of intracellular insulin processing
23. A novel pancreatic endocrine tumor suppressor gene locus on chromosome 3p with clinical prognostic implications
24. Frequent loss of heterozygosity at chromosome 3p14.2-3p21 in human pancreatic islet cell tumours
25. Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas
26. Origins of human cancer revisited
27. Genetic sequences that predispose to retinoblastoma and osteosarcoma
28. Homozygous deletion map at 18q21.1 in pancreatic cancer
29. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
30. Positional cloning of the gene for multiple endocrine neoplasia type 1
31. Multiple allelic deletions and intratumoral genetic heterogeneity in MEN1 pancreatic tumors
32. The DNA sequence of human chromosome 22
33. Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix
34. hSNF5/INI1 inactivation is mainly associated with homozygous deletions and mitotic recombinations in rhabdoid tumors
35. Spectrum of hSNF5/INI1 somatic mutations in human cancer and genotype-phenotype correlations
36. Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers
37. Alteration of hSNF5INI1/BAF47 detected in rhabdoid cell lines and primary rhabdomyosarcomas but not Wilms' tumors
38. Frequent deletion of hSNF5/INI1, a component of the SWI/SNF complex, in chronic myeloid leukemia
39. Absence of hSNF5/INI1 mutation in human lung cancer
40. Distribution patterns of proinsulin and insulin in human insulinomas: An immunohistochemical analysis in 76 tumors
41. Topographic abnormalities of proinsulin to insulin conversion in functioning human insulinomas
42. Endocrine tumors of the pancreas: Ki-67 immunoreactivity on paraffin sections is an independent predictor for malignancy