An in vivo binding assay to determine central α1-adrenoceptor occupancy using [3H]prazosin

Brain Research Protocols

Volumn 8, Issue 3, 2001, Pages 191-198

  Patel, Shil ^a   Fernandez Garcia, Eva ^b   Hutson, Peter H ^b   Patel, Smita ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Adrenoceptor; In vivo receptor occupancy; Radioligand binding

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BENOXATHIAN; CIRAZOLINE; CLONIDINE; CLOZAPINE; HALOPERIDOL; NAFTOPIDIL; PHENTOLAMINE; PRAZOSIN; TRITIUM;

ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; BRAIN MEMBRANE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; IN VIVO STUDY; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR OCCUPANCY; RECEPTOR POTENTIAL; SPECIES DIFFERENCE;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BINDING, COMPETITIVE; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MEMBRANES; MICE; MICE, INBRED STRAINS; PRAZOSIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; SPECIES SPECIFICITY;

EID: 0035216082     PISSN: 1385299X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1385-299X(01)00110-6     Document Type: Article

References (24)

1. The citalopram/5-HTP-induced head shake syndrome is correlated to 5-HT2 receptor affinity and also influenced by other transmitters
2. A receptors
3. Phencyclidine-induced deficits in prepulse inhibition of startle are blocked by prazosin, an alpha-1 noradrenergic antagonist
4. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principal of protein-dye binding
5. In vivo receptor occupancy of NRA0045, a putative atypical antipsychotic in rats
6. 50) of an enzymatic reaction
7. Effect of injury on the bi-affinity α1-adrenoceptor binding in rat brain in vivo
8. 1-adrenoceptor mediating contractions of rat vas deferens
9. 1-Adrenoceptors in hippocampus of pigs, guinea-pigs, calves and humans: Regional differences
10. 2A antagonist with a favourable CNS safety profile
11. 3H]tamsulosin in human hypertrophied prostate using computerised image analysis
12. 1-adrenoceptor subtypes in bovine prostate and rat heart and brain
13. Binding in vivo of selective μ and δ opioid receptor agonists: Opioid receptor occupancy by endogenous enkephalins
14. 3H]prazosin binding
15. 1A-adrenoceptor radioligand to rat and human tissues
16. Ex vivo and in vivo alpha1-adrenoceptor binding characteristics of a novel alpha1-l-adrenoceptor antagonist, JTH-601, in rat tissues
17. Alpha-1 adrenoceptors in the mammalian brain: Similar pharmacology but different distribution in rodents and primates
18. Modulation of vigilance and behavioural activation by alpha-1 adrenoceptors in the rat
19. The attraction of proteins for small molecules and ions
20. Dopamine receptor pharmacology
21. 3H]prazosin binding to glass-fibre filters and glass surfaces
22. 1-adrenoceptor antagonists for treatment of benign prostatic hyperplasia
23. Noradreneregic alpha-1 and alpha-2 receptors: Light microscopic autoradiographic localisation
24. 1-adrenoceptors and their subtypes in human and rat hippocampus