The role of CD44 during CD40 ligand-induced dendritic cell clustering and maturation

Journal of Leukocyte Biology

Volumn 70, Issue 5, 2001, Pages 715-722

  Termeer, Christian ^a   Johannsen, Henning ^a   Braun, Thorsten ^a   Renkl, Andreas ^a   Ahrens, Thomas ^b   Denfeld, Ralph W ^a   Lappin, Mike B ^c   Weiss, Johannes M ^a   Simon, Jan C ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

CD154; Hyaluronic acid; IL 1 ; MHC; TNF

Indexed keywords

ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD44 ANTIBODY; HERMES ANTIGEN; HYALURONIC ACID; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL ADHESION; CELL MATURATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FIBROBLAST; GENETIC TRANSFECTION; LIGAND BINDING; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TIME; VIDEORECORDING; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD44; CD40 LIGAND; CELL ADHESION; CELL AGGREGATION; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; FIBROBLASTS; GENE EXPRESSION REGULATION; GLUCURONOSYLTRANSFERASE; GLYCOSYLTRANSFERASES; HUMANS; HYALURONIC ACID; HYALURONOGLUCOSAMINIDASE; MEMBRANE PROTEINS; MICE; PROTEIN ISOFORMS; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TRANSFERASES; TUMOR NECROSIS FACTOR-ALPHA; XENOPUS PROTEINS;

ANIMALIA; MURINAE;

EID: 0035213011     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Activation of human dendritic cells through CD40 cross-linking
2. Requirement of mature dendritic cells for efficient activation of influenza A-specific memory CD8+ T cells
3. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
4. Dendritic cells require maturation via CD40 to generate protective antitumor immunity
5. Optimization of the sequence of antigen loading and CD40-ligand-induced maturation of dendritic cells
6. CD40-CD40 ligand
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8. MHC class II and CD40 play opposing roles in dendritic cell survival
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10. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
11. Dendritic cells and resting B cells form clusters in vitro and in vivo: T cell independence, partial LFA-1 dependence, and regulation by cross-linking surface molecules
12. Cutting edge: An inducible sialidase regulates the hyaluronic acid binding ability of CD44-bearing human monocytes
13. Adhesive and/or signaling functions of CD44 isoforms in human dendritic cells
14. Regulated clustering of variant CD44 proteins increases their hyaluronate binding capacity
15. The role of the CD44 cytoplasmic and transmembrane domains in constitutive and inducible hyaluronan binding
16. CD44 is the principal cell surface receptor for hyaluronate
17. Activation-dependent modulation of hyaluronate-receptor expression and of hyaluronate-avidity by human monocytes
18. Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13
19. CD44-mediated adhesiveness of human hematopoietic progenitors to hyaluronan is modulated by cytokines
20. Two different functions for CD44 proteins in human myelopoiesis
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22. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H
23. Hyaluronate is costimulatory for human T cell effector functions and binds to CD44 on activated T cells
24. Hyaluronate-CD44 interactions can induce murine B-cell activation
25. Hyaluronate-enhanced hematopoiesis: Two different receptors trigger the release of interleukin-1beta and interleukin-6 from bone marrow macrophages
26. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
27. Molecular identification of a putative human hyaluronan synthase
28. Preparation and properties of fluorescein-labelled hyaluronate
29. Hyaluronan binding function of CD44 is transiently activated on T cells during an in vivo immune response
30. Synthesis and shedding of hyaluronan from plasma membranes of human fibroblasts and metastatic and non-metastatic melanoma cells
31. Oligosaccharides of hyaluronan are potent activators of dendritic cells
32. Hyaluronan bound to CD44 on keratinocytes is displaced by hyaluronan decasaccharides and not hexasaccharides
33. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons
34. CD45R, CD44 and MHC class II are signaling molecules for the cytoskeleton-dependent induction of dendrites and motility in activated B cells
35. Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes
36. CD44 supports T cell proliferation and apoptosis by apposition of protein kinases
37. Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor kappaB-dependent mechanism
38. Angiogenic oligosaccharides of hyaluronan induce protein tyrosine kinase activity in endothelial cells and activate a cytoplasmic signal transduction pathway resulting in proliferation
39. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
40. CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L
41. CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodes