Inhibition of proliferation of HT-29 colon adenocarcinoma cells by carboxylate NSAIDs and their acyl glucuronides

Life Sciences

Volumn 70, Issue 1, 2001, Pages 37-48

  Cannell, Graeme R ^a   Vesey, David A ^a   Dickinson, Ronald G ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

Acyl glucuronides; Antiproliferative effects; Colon cancer; HT 29 cells; Nonsteroidal anti inflammatory drugs

Indexed keywords

ACYLGLUCURONIDE; ANTICONVULSIVE AGENT; DICLOFENAC; DIFLUNISAL; GLUCURONIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; THYMIDINE; UNCLASSIFIED DRUG; VALPROIC ACID; ZOMEPIRAC;

ANIMAL EXPERIMENT; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL DIVISION; CELL PROLIFERATION; COLON ADENOCARCINOMA; CONTROLLED STUDY; CYTOSOL; DRUG ACTIVITY; DRUG EFFECT; DRUG HYDROLYSIS; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; INCUBATION TIME; ISOMER; MALE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN MODIFICATION; RAT;

ACYLATION; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL DIVISION; DICLOFENAC; DIFLUNISAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCURONIDES; HT29 CELLS; HUMANS; PIROXICAM; STEREOISOMERISM; THYMIDINE; TOLMETIN; VALPROIC ACID;

EID: 0035212147     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01370-4     Document Type: Article

References (47)

1. Cancer statistics
2. Epidemiology and risk factors for colorectal cancer
3. Diet and chemoprevention of colon polyps and colorectal cancer
4. Pharmacologic prevention of neoplasms
5. Mechanisism of inhibition of toumour growth by aspirin and indomethacin
6. Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine
7. Inhibition of initiation and promotion by N-methylnitrosourea-induced colon carcinogenesis by non-steroidal anti-inflammatory agent indomethacin
8. Sulindac for polyposis of the colon
9. A hypothesis: Nonsteroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer
10. Aspirin use and reduced risk of fatal colon cancer
11. Sulindac causes regression of rectal polyps in familial adenomatous polyposis
12. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis
13. Adenomatous polyposis coli, protein kinases, protein tyrosine phosphatase: The effect of sulindac
14. Nonsteroidal anti-inflammatory drugs, eicosanoids, and colorectal cancer prevention
15. Use of nonsteroidal anti-inflammatory drugs and incidence of colorectal cancer: A population-based study
16. Piroxicam and other cyclooxygenase inhibitors: Potential for cancer chemoprevention
17. Aspirin and related nonsteroidal anti-inflammatory drugs as chemopreventive agents against colon cancer
18. Chemoprevention of colorectal cancer
19. Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells
20. Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: Effects on cell cycle and apoptosis
21. Effect of non-steroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglan-din-independent pathway
22. Stimulation of apoptosis by sulindac and piroxicam
23. Effect of aspirin on induction of apoptosis in HT-29 human colon adenocarcinoma cells
24. Nonsteroidal anti-inflammatory drugs, short-chain fatty acids, and reactive oxygen metabolism in human colorectal cancer cells
25. Antiproliferative effects of nonsteroidal antiinflammatory drugs against human colon cancer cells
26. Sulindac sulfide alters the expression of cyclic proteins in Ht-29 colon adenocarcinoma cells
27. Acyl glucuronides revisited: Is the glucuronidation process a toxification as well as a detoxification mechanism?
28. Acyl glucuronide conjugates - Reactive metabolites of non-steroidal anti-inflammatory drugs
29. Acyl glucuronides as chemically reactive intermediates
30. Acylation of albumin by 1-O-acyl glucuronides
31. Reactions of oxaprozin 1-O-acyl glucuronidein solutions of human plasma and albumin
32. Irreversible binding of zomepirac to plasma proteinin vitroandin vivo
33. Evidence for the covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry
34. Disposition and irreversible plasma protein binding of tolmetin in humans
35. Studies on the reactivity of acyl glucuronides-VI: Modulation of reversible and covalent interaction of diflunisal acyl glucuronide and its isomers with human plasma proteinin vitro
36. Stereoselective interactions of ketoprofen glucuronides with human plasma protein and serum albumin
37. Chemical and immunochemical comparison of protein adduct formation of four carboxylate drugs in rat liver and plasma
38. Zomepirac acyl glucuronide covalently modifies tubulin in vitro and in vivo and inhibits its assembly in an in vitro system
39. Rearrangement of diflunisal acyl glucuronide into itsb-glucuronidase-resistant isomers facilitates transport through the small intestine to the colon of the rat
40. Studies on the reactivity of acyl glucuronides-I. Phenolic glucuronidation of isomers of diflunisal acyl glucuronide in the rat
41. The utility of the bile-exteriorized rat as a source of reactive acyl glucuronides: Studies with zomepirac
42. Studies on the reactivity of acyl glucuronides-III. Glucuronide-derived adducts of valproic acid and plasma protein and anti-adduct antibodies in humans
43. Reactivity of diflunisal acyl glucuronide in human and rat plasma and albumin solutions
44. Stability of acyl glucuronides in blood, plasma and urine: Studies with zomepirac
45. Evaluation of in vitro cytotoxicity of nonsteroidal anti-inflammatory drugs against canine tumor cells
46. Cell-type dependent effect of sodium valproate on human immunodefiency virus type 1 replication in vitro
47. Different mechanisms of protection against apoptosis by valproate and Li1