Chemoprevention of colorectal cancer

Gastroenterology Clinics of North America

Volumn 25, Issue 4, 1996, Pages 821-858

  Krishnan, K ^a   Brenner, D E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BIOLOGICAL MARKER; CALCIUM; CAROTENOID; CURCUMIN; EFLORNITHINE; ELLAGIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; OLTIPRAZ; REGULATOR PROTEIN; RETINOID; SULINDAC;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CANCER PREVENTION; CELL GROWTH; CHEMOPROPHYLAXIS; COLON CARCINOGENESIS; COLORECTAL CANCER; CYTOLOGY; EPITHELIUM CELL; FRUIT; GENETICS; HOMEOSTASIS; HUMAN; NONHUMAN; NUTRITION; POLYAMINE METABOLISM; REVIEW; SIGNAL TRANSDUCTION; TUMOR CELL; VEGETABLE;

EID: 0030451358     PISSN: 08898553     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8553(05)70277-6     Document Type: Article

References (219)

1. H. Abou-Issa V.A. Duruibe Anticarcinogenic effect of retinoids on 7,12-dimethylbenz(a)antracene-induced mammary tumor induction, and its relationship to cyclic AMP-dependent protein kinase Biochem Biophys Res Commun 135 1986 116 123
2. D.S. Alberts J. Einspahr S. Rees-McGee Effects of dietary wheat bran fiber on rectal epithelial cell proliferation in patients with resection for colorectal cancers J Natl Cancer Inst 82 1990 1280 1285
3. H.P.T. Ammon M.A. Wahl Pharmacology of curcumin Planta Med 57 1991 1 7
4. F.L. Arlow S.M. Walczak G.D. Luk Attenuation of azoxymethane-induced colonic mucosal ornithine decarboxylase and tyrosine kinase activity by calcium in rats Cancer Res 49 1989 5884 5888
5. H. Autrup C.C. Harris Metabolism of chemical carcinogens by human tissues C.C. Harris Autrup H. Human Carcinogenesis 1983 Academic Press New York 169 194
6. D.H. Barch L.M. Rundhangen Ellagic acid induces NAD(P)H: Quinone reductase through activation of the antioxidant responsive element of the rat NAD(P)H: quinone reductase gene Carcinogenesis 15 1994 2065 2068
7. S. Baron K.M. Kleyn J.K. Russell Retinoic acid: Enhancement of a tumor and inhibition of interferon's antitumor action J Natl Cancer Inst 67 1981 95 97
8. S.E. Benner S.M. Lippman W.K. Hong Current status of chemoprevention of head and neck cancer Oncology 6 1992 61 68
9. S.E. Bennet R.J. Winn S.M. Lippman Regression of oral leukoplakia with alpha-tocopherol: A community clinical oncology program chemoprevention study J Natl Cancer Inst 85 1993 44 47
10. R.P. Bird Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findings Cancer Lett 37 1987 147 151
11. D.F. Birt S. Sayed Sex differences in the effects of retinoids on carcinogenesis by N-nitrosobis-(2-oxypropyl) amine in Syrian hamsters Cancer Lett 14 1981 13 21
12. G. Block M. Menkes Ascorbic acid in cancer prevention T. Moon Micozzi M. Nutrition and Cancer Prevention: The Role of Micronutrients 1988 Marcel Dekker New York
13. W.J. Blot Li J.-Y. P.R. Taylor Nutrition intervention trials in Linxian, China: Supplementation with specific vitamin/mineral combinations, cancer incidence and disease specific mortality in the general population J Natl Cancer Inst 85 1993 1483 1492
14. S. Blum E.A. Offord K. Mace Establishment of a human colon cell model with intestinal properties Proc Am Assoc Cancer Res 37 1996 A788
15. M.G. Bolton A. Munoz L.P. Jacobson Transient intervention with oltipraz protects against aflatoxin-induced hepatic tumorigenesis Cancer Res 53 1993 3499 3504
16. C.W. Boone G.J. Kelloff Intraepithelial neoplasia, surrogate endpoint biomarkers, and cancer chemoprevention J Cell Biochem 17 1993 37 48
17. C.W. Boone G.J. Kelloff W.E. Malone Identification of candidate chemopreventive agents and their evaluation in animal models and human clinical trials: A review Cancer Res 50 1990 2 9
18. R.M. Bostick J.D. Potter L. Fosdick Calcium and colorectal epithelial cell proliferation: A preliminary randomized, double-blinded, placebo-controlled clinical trial J Natl Cancer Inst 85 1993 132 141
19. R.M. Bostick J.D. Potter T.A. Sellers Relation of calcium, vitamin D, and dairy food intake to incidence of colon cancer among older women: The Iowa Women's Health Study Am J Epidemiol 137 1993 1302 1317
20. J. Buring C. Hennekens The possible role of beta-carotene in cancer prevention Cancer Prev July 1989 1 9
21. D.P. Burkitt Epidemiology of cancer of the colon and rectum Cancer 28 1971 3 13
22. K. Burney K. Krishnan M.T. Ruffin Adherence to single daily dose of aspirin in a chemoprevention trial: An evaluation of self-report and microelectronic monitoring Arch Fam Med 5 1996 297 300
23. M. Buset M. Lipkin S. Winawer Inhibition of human colonic epithelial cell proliferation in vivo and in vitro by calcium Cancer Res 46 1987 5426 5430
24. H.R.J. Bussey J.J.H. DeCosse E.E. Deschner A randomized trial of ascorbic acid in polyposis coli Cancer 50 1982 1434 1439
25. Associates CCS Draft Clinical Development Plan Curcumin, for Chemoprevention Branch and Agent Development Committee 1995 National Cancer Institute, Division of Cancer Prevention and Control Washington, DC
26. Z. Chen U. Gundimeda R. Gopalakrishna Curcumin irreversibly inactivates protein kinase C activity and phorbol ester binding: Its possible role in cancer chemoprevention Proc Am Assoc Cancer Res 37 1996 A1922
27. D.P. Chopra L.J. Wilkoff Reversal by vitamin A analogues (retinoids of hyperplasia induced by N-methyl-N′-nitro-N-nitrosoguanidine in mouse prostate organ cultures J Natl Cancer Inst 58 1977 923 930
28. D.P. Chopra L.J. Wilkoff Effect of retinoids and estrogen on testosterone-induced hyperplasia of mouse prostate explants in organ culture Proc Soc Exp Biol Med 162 1979 229 234
29. M.L. Clapper L.C. Everly L.A. Strobel Coordinate induction of glutathione s-transferase αμ and II expression in murine lines after a single administration of oltipraz Molec Pharmacol 45 1994 489
30. T.A. Colacchio V.A. Memoli L. Hildebrandt Antioxidant vs carotenoids: Inhibitors or promoters of experimental colorectal cancers Arch Surg 124 1989 217 221
31. M.J. Connor R.E. Ashton N.J. Lowe A comparative study of the induction of epidermal hyperplasia by natural and synthetic retinoids J Pharm Exp Ther 237 1986 31 35
32. M.J. Connor N.J. Lowe Retinoid stimulation of epidermal cell growth in vivo Sauret J.H. Retinoids: New Trends in Research and Therapy 1985 S Karger Basel 198 210
33. P.A. Craven F.R. DeRubertis Profiles of eicosanoid production by superficial and proliferative colonic epithelial cells and sub-epithelial cells and sub-epithelial colonic tissue Prostaglandins 32 1986 387 399
34. P.A. Craven F.R. DeRubertis Effects of aspirin on 1,2-dimethylhydrazine-induced colonic carcinogenesis Carcinogenesis 13 1992 541 546
35. P.A. Craven L. Penyala N.J. Petrelli Evaluation of α-difuoromethylornithine as a potential chemopreventive agent: Tolerance to daily oral administration in humans Cancer Epidemiol Biomark Prev 2 1993 243 247
36. P.A. Craven K. Thornburg F.R. DeRubertis Sustained increase in the proliferation of rat colonic mucosa during chronic treatment with aspirin Gastroenterology 94 1988 567 575
37. J.J. DeCosse H. Miller M. Lesser Effect of wheat fiber and vitamins C and E on rectal polyps in patients with familial and adenomatous polyposis J Natl Cancer Inst 81 1989 1290 1297
38. S.D. Deodhar R. Sethi R.C. Srimal Preliminary study on antirheumatic activity of curcumin (diferyloyl methane) Ind J Med Res 71 1980 632 634
39. F.R. DeRubertis P.A. Craven Early alterations in rat colonic mucosal cyclic nucleotide metabolism and protein kinase activity induced by 1,2-dimethylhydrazine Cancer Res 40 1980 4589 4598
40. R. Dixit B. Gold Inhibition of N-methyl-N-nitrosourea-induced mutagenicity and DNA methylation by ellagic acid Proc Natl Acad Sci 83 1986 8039 8043
41. I.A. Donatus Sardjoko N.P. Vermeulen Cytotoxic and cytoprotective activities of curcumin: Effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes Biochem Pharmacol 39 1990 1869 1875
42. J.F. Dorgan A. Schatzkin Antioxidant micronutrients in cancer prevention Hematol Oncol Clin North Am 5 1991 43 68
43. R.N. DuBois M. Tsujii P. Bishop Cloning and characterization of a growth factor inducible cyclooxygenase gene from rat intestine alpithelial cells Am J Physiol 266 1994 822 829
44. M. Ehrlich J.E. Aswell Van Tassell R.L. Mutagens in the feces of three South African populations at different levels of risk for colon cancer Mutat Res 64 1979 231 240
45. PF Engstrom, FL Meyskens, Cancer prevention, DiSaia P, Principles and Practice of Gynecologic Oncology, ed 2. Philadelphia
46. E.R. Fearon B. Vogelstein A genetic model for colorectal tumorigenesis Cell 61 1990 759 767
47. G. Finley M. Melhem Cytokine expression in colorectal adenocarcinoma and mucosa Proc Am Assoc Cancer Res 37 1996 A1090
48. W. Friend Sulindac suppression of colorectal polyps in Gardner's syndrome Am Fam Phys 41 1990 891 894
49. C. Garland R.B. Shekelle E. Barrett-Connor Dietary vitamin D and calcium and risk of colorectal cancer: A 19-year prospective study in men Lancet 1 1985 307 309
50. H. Gerster Anticarcinogenic effect of common carotenoids Int J Vit Nutr 63 1993 93 121
51. F.M. Giardiello S.R. Hamilton A.J. Krush Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis N Engl J Med 328 1993 1313 1316
52. E. Giovannucci E.B. Rimm A. Ascherio Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men J Natl Cancer Inst 87 1995 265 273
53. E. Giovannucci E.B. Rimm M.J. Stampfer Aspirin use and the risk for colorectal cancer and adenoma in male health professionals Ann Intern Med 121 1994 241 246
54. Y. Goldberg K. Pittas J.C. Reed Sulindac and sulindac sulfide alter the levels of bcl-2 and bax proteins in HT-29 colon cancer cells Gastroenterology 108 1995 A475
55. E.R. Greenberg J.A. Baron Freeman D.H. Jr Reduced risk of large-bowel adenomas among aspirin users J Natl Cancer Inst 85 1993 912 916
56. E.R. Greenberg J.A. Baron T.A. Stukel A clinical trial of beta-carotene to prevent basal-cell and squamous-cell cancers of the skin: The Skin Cancer Prevention Study Group N Engl J Med 323 1990 789 795
57. E.R. Greenberg J.A. Baron T.D. Tosteson A clinical trial of antioxidant vitamins to prevent colorectal adenoma: Polyp Prevention Study Group N Engl J Med 331 1994 141 147
58. P. Greenwald Chemoprevention research in the U.S. National Cancer Institute Milit Med 159 1994 505 512
59. P. Greenwald G. Kelloff C. Burch-Whitman Chemoprevention CA Cancer J Clin 45 1995 31 49
60. P. Greenwald D.W. Nixon W.F. Malone Concepts in cancer chemoprevention research Cancer 65 1990 1483
61. R.C. Gregoire H.S. Stern D.S. Yeung Effect of calcium supplementation on mucosal cell proliferation in high risk patients for colon cancer Gut 30 1989 376 382
62. M. Grilli Chiu J.J.-S. M.J. Lenardo NF-kappa B and Rel: Participants in a multiform transcriptional system Int Rev Cytol 143 1993 1 62
63. E.M. Haliday C.S. Ramesha G. Ringold TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite EMBO J 10 1991 109 115
64. L. Harisiadis R.C. Miller F.J. Hall A vitamin A analogue inhibits radiation-induced oncogenic transformation Nature 274 1978 486 487
65. S.R. Heckbert N.S. Weiss S.K. Harmung Glutathione s-transferase and eposide hydrolase activity in human leucocytes in relation to risk of lung cancer and other smoking-related cancers J Natl Cancer Inst 84 1992 414
66. Alpha-Tocopherol The Beta Carotene Cancer Prevention Study Group The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers N Engl J Med 330 1994 1029 1035
67. C.H. Hennekens J.E. Buring J.E. Manson Lack of effect of long-term supplementation with beta-carotene on the incidence of malignant neoplasms and cardiovascular disease N Engl J Med 334 1996 1145 1149
68. L.J. Hixson D.L. Earnest M.B. Fennerty NSAID effect on sporadic colon polyps Am J Gastroenterol 88 1993 1652 1656
69. W.K. Hong J. Endicott L. Itri 13-cis-retinoic acid in the treatment of oral leukoplakia N Engl J Med 315 1986 1501 1505
70. W.K. Hong S.M. Lippman L. Itri Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck N Engl J Med 323 1990 795 801
71. G.R. Howe E. Benito R. Castelleto Dietary intake of fiber and decreased risk of cancer of the colon and rectum: Evidence from combined analysis of 13 case control studies J Natl Cancer Inst 84 1992 1887 1896
72. M.-T. Huang Lou Y.-R. W. Ma Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice Cancer Res 54 1994 5841 5847
73. Huang M.-T. T. Lysz T. Ferraro Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis Cancer Res 51 1991 813 819
74. Huang M.-T. Z.Y. Wang C.A. Georgiadis Inhibitory effect of curcumin chlorogenic acid caffeic acid and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate Cancer Res 48 1988 5941 5946
75. Huang M.-T. Z.Y. Wang C.A. Georgiadis Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene Carcinogenesis 13 1992 2183 2186
76. S.D. Hursting M. Thornquist M.M. Henderson Types of dietary fat and the incidence of cancer at five sites Prev Med 19 1990 242 253
77. M. Jain J.D. Burch G.R. Howe Dietary factors and risk of lung cancer: Results from a case-control study, Toronto, 1981–1985 Int J Cancer 45 1990 287 293
78. R.A. Karmali Prostaglandins and cancer Prostaglandins Med 5 1980 11
79. G.J. Kelloff C.W. Boone V.E. Steele Mechanistic considerations in chemopreventive drug development J Cell Biochem 20 suppl 1994 1 1994
80. G.J. Kelloff J.R. Johnson J.A. Crowell Approaches to the development and marketing approval of drugs that prevent cancer Cancer Epidemiol Biomark Prev 4 1995 1 10
81. T.W. Kensler G.C. Mueller Retinoic acid inhibition of the comitogenic action of mezerein and phorbol esters in bovine lymphocytes Cancer Res 38 1979 771 775
82. T. Kensler P. Stczynski J. Groopman Mechanisms of chemoprotection by oltipraz J Cell Biochem 16I suppl 1992 167 172
83. S.P. Klinken M.J. Castilla S.S. Thorgiersson Effect of inhibitors of ornithine decarboxylase on retrovirus induced transformation of murine erythroid precursors in vitro Cancer Res 46 1986 6246 6249
84. E. Kopp S. Ghosh Inhibition of NF-κB by sodium salicylate and aspirin Science 265 1994 956 959
85. 2α in human rectal tissue Gastroenterology 106 1994 A405
86. N.I. Krinsky S.M. Deneke Interaction of oxygen and oxyradicals with carotenoids J Natl Cancer Inst 69 1982 205 210
87. E. Kunchandy M.N. Rao Oxygen radical scavenging activity of curcumin Int J Pharmaceut 58 1990 237 240
88. G.A. Kune S. Kune L.F. Watson Colorectal cancer risk, chronic illnesses, operations and medications: Case control results from the Melborne Colorectal Cancer Study Cancer Res 48 1988 4399 4404
89. D. Labayle D. Fischer P. Vielh Sulindac causes regression of rectal polyps in familial adenomatous polyposis Gastroenterology 101 1991 635 639
90. J.I. Lans R. Jaszewski F.L. Arlow Supplemental calcium suppresses colonic mucosal ornithine decarboxylase activity in elderly patients with adenomatous polyps Cancer Res 51 1991 3416 3419
91. T. Lawson S. Stohs Changes in endogenous DNA damage in aging mice in response to butylated hydroxyanisole and oltipraz Mech Aging Dev 30 1985 179 185
92. F.S. Leach N.C. Nicolaides N. Papadopoulos Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer Cell 75 1993 1215 1225
93. M. Linder Nutrition and metabolism of vitamins Linder M. Nutritional Biochemistry and Metabolism with Clinical Applications 1985 Elsevier Science New York 115 122
94. M. Lipkin Current trends in chemoprevention research Eur J Cancer Prev 3 1994 368 371
95. M. Lipkin B. Levin Y.S. Kim Intermediate biomarkers of precancer and their application in chemoprevention J Cell Biochem 16G suppl 1992 1 196
96. M. Lipkin H.L. Newmark Effect of added dietary calcium on colonic epithelial cell proliferation in subjects at high risk for familial colon cancer N Engl J Med 313 1985 1381 1384
97. S.M. Lippman S.E. Benner W.K. Hong Cancer chemoprevention J Clin Oncol 12 1994 851 873
98. S.M. Lippman W.N. Hittelman R. Lotan Recent advances in cancer chemoprevention Cancer Cells 3 1991 59 65
99. S.M. Lippman J.S. Lec R. Lotan Biomarkers as intermediate endpoints in chemoprevention trials J Natl Cancer Inst 82 1990 555
100. R.F.A. Logan J. Little P.G. Hawtin Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: Case-control study of subjects participating in the Nottingham faecal occult blood screening programme BMJ 307 1993 285 289
101. R.R. Love P.P. Carbone A.K. Verma Randomized phase I chemoprevention dose seeking study of α-difluoromethylornithine J Natl Cancer Inst 85 1993 732 737
102. Y.P. Lu R.L. Chang Huang M.-T. Inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate induced increase in ornithine decarboxylase mRNA in mouse epidermis Carcinogenesis 14 1993 293 297
103. C. Luongo A.R. Moser S. Gledhill Loss of Apc+ in intestinal adenomas from Min mice Cancer Res 54 1994 5947 5952
104. N.R. Lynch M. Castes M. Astoin Mechanism of inhibition of tumour growth by aspirin and indomethacin Br J Cancer 38 1978 503 512
105. D.J. Mangelsdorf K. Umesono R.M. Evans The retinoid receptors M. Sporn A. Roberts Goodman D. The Retinoids: Biology, Chemistry, and Medicine 1994 Raven Press New York 319 349
106. L.J. Marnett Aspirin and the role of prostaglandins in colon cancer Cancer Res 52 1992 5575 5589
107. C. Marth G. Bock G. Daxenbichier Effect of 4-hydroxyphenyl-retinamide and retinoic acid on proliferation and cell cycle of human breast cancer cells J Natl Cancer Inst 75 1985 871 875
108. M.W. McBurney S. Costa M.A.C. Pratt Retinoids and cancer: A basis for differentiation therapy Cancer Invest 11 1993 590 598
109. D.L. McCormick R.G. Mehta Enhanced inhibition of mammary carcinogenesis by combined treatment with N-(4-hydroxyphenyl) retinamide and ovariectomy Cancer Res 42 1982 508 512
110. D.L. McCormick R.C. Moon Antipromotional activity of dietary N-(4-hydroxyphenyl) retinamide in two-stage skin tumorigenesis in CD-a and Senecar mice Cancer Lett 31 1986 133 138
111. G. McKeown-Eyssen A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps Cancer Res 48 1988 4701 4705
112. J.K. McLaughlin G. Gridley G. Block Dietary factors in oral and pharyngeal cancer J Natl Cancer Inst 80 1988 1237 1243
113. E.A. Meade W.L. Smith D.L. DeWitt Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs J Biol Chem 268 1993 6610 6614
114. Meyskens F.L. Jr Thinking about cancer causation and chemoprevention J Natl Cancer Inst 80 1988 1278
115. Meyskens F.L. Jr D.S. Alberts S.E. Salmon Effect of 13 cis retinoic acid and 4 hydroxyphenyl all trans-retinamide on human tumor colony formation in soft agar Int J Cancer 32 1983 295 299
116. Meyskens F.L. Jr D.S. Emerson D. Pelot Dose de-escalation chemoprevention trial of alpha difluoromethyornithine in patients with colon polyps J Natl Cancer Inst 86 1994 1122 1130
117. E.C. Millers J.A. Miller Mechanisms of chemical carcinogenesis: The nature of proximate carcinogens and interactions with macromolecules Pharmacol Rev 18 1966 805 838
118. RC Moon, Chemoprevention of bladder carcinogenesis by a combination of sodium selinite and 4-hydroxyphenyl retinamide. Washington, DC, National Cancer Institute by IIT Research Institute, under contract No. NO1-CN-45192-05, 1986.
119. R.C. Moon Comparative aspects of carotenoids and retinoids as chemopreventive agents for cancer J Nutr 119 1989 127 134
120. R.C. Moon C.J. Detrisac C.F. Thomas Chemoprevention of experimental bladder cancer J Cell Biochem 16I suppl 1992 134 138
121. R.C. Moon D.L. McCormick R.G. Mehta Inhibition of carcinogenesis by retinoids Cancer Res 43 1983 2469s 2475s
122. R.C. Moon R.G. Mehta Chemoprevention of experimental mammary cancer by retinoids De Palo G. Sporn M. Veronesi U. Progress and Perspectives in Chemoprevention of Cancer 1992 Serono Symposia Publications New York 13 22
123. R.C. Moon H.J. Thompson N-(4-hydroxyphenyl) retinamide, a new retinoid for prevention of breast cancer in the rat Cancer Res 39 1979 1339 1346
124. M. Moorghen P. Ince K.J. Finney The effect of sulindac on colonic tumour formation in dimethylhydrazine-treated mice Acta Histochem suppl 39 1990 195 199
125. A. Mukhopadhyay N. Basu N. Ghatak Anti-inflammatory and irritant activities of curcumin analogues in rats Agents Actions 12 1982 508 515
126. J.L. Mulshine M. Jett F. Cuttitta Scientific basis for cancer prevention: Intermediate cancer markers Cancer 72 1993 978
127. M. Nagabhushan S.B. Bhide Curcumin as an inhibitor of cancer J Am Coll Nutr 11 1992 192 198
128. H. Nagasawa R. Konsihi N. Sensui Inhibition by beta-carotene rich Algae dunaliella of spontaneous mammary tumorigenesis in mice Anticancer Res 9 1989 71 75
129. D.L. Newton W.R. Henderson M.B. Sporn Structure-activity relationships of retinoids in hamster tracheal organ culture Cancer Res 40 1980 3413 3425
130. W.A. Nijhoff W.H. Peters Quantification of induction of rat esophageal gastric and pancreatic glutathione and glutathione-S-transferases by dietary anticarcinogens Carcinogenesis 15 1994 1769 1772
131. I. Nishisho Y. Nakamura Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients Science 253 1991 665 669
132. Y. Niv G.M. Fraser Adenocarcinoma in the rectal segment in familial polyposis coli is not prevented by sulindac therapy Gastroenterology 107 1994 854 857
133. K.P. Nugent K.C.R. Farmer A.D. Spigelman Randomized controlled clinical trial of sulindac on intestinal polyposis in FAP Br J Surg 80 1993 1618 1619
134. M. Ohshima J.M. Ward M.L. Wenk Preventive and enhancing effects of retenoids on the development of naturally occuring tumors of skin, prostate gland, and endocrine pancreas in aged male ACI/segHapBR rats J Natl Cancer Inst 74 1985 517 524
135. G.S. Omenn G.E. Goodman M.D. Thornquist Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease N Engl J Med 334 1996 1150 1155
136. G.M. Paganelli G. Biasco G. Brandl Effects of vitamin A, C, and E supplementation on rectal cell proliferation in patients with colorectal adenoma J Natl Cancer Inst 84 1992 47
137. A. Paganini-Hill A. Chao R. Ross Aspirin use and chronic diseases: A cohort study of the elderly BMJ 299 1989 1247 1250
138. A. Paganini-Hill G. Hsu R.K. Ross Aspirin use and incidence of large bowel cancer in a California retirement community J Natl Cancer Inst 83 1991 1182 1183
139. R. Parsons G.M. Li M.J. Longley Hypermutability and mismatch repair deficiency in RER+ tumor cells Cell 75 1993 1227 1236
140. P.J. Pasricha A. Bedi K. O'Connor The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis Gastroenterology 109 1995 994 998
141. U. Pastorino Lung cancer chemoprevention: Facts and hopes Lung Cancer 7 1991 133 150
142. A.E. Pegg Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy Cancer Res 48 1988 759 774
143. I.I. Peleg H.T. Maibach S.H. Brown Aspirin and nonsteroidal anti-inflammatory drug use and risk of subsequent colorectal cancer Arch Intern Med 154 1994 394 399
144. R. Peto R. Doll J.D. Buckley Can dietary beta-carotene materially reduce human cancer rates? Nature 290 1981 201 208
145. G.A. Piazza A.L. Rahm M. Krutzsch Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis Cancer Res 55 1995 3110 3116
146. G.E. Pipkin Inhibitory effect of L-ascorbate on tumor formation in urinary bladders implanted with 3-hydroxyanthranilic acid Proc Soc Exp Biol Med 131 1969 522 524
147. M. Pollard P.H. Luckert Treatment of chemically-induced intestinal cancer with indomethacin Proc Soc Exp Biol Med 167 1981 161 164
148. M. Pollard P.H. Luckert Effect of indomethacin on intestinal tumor induced in rats by the acetate derivative of dimethylnitrosamine Science 214 1981 558 559
149. M. Pollard P.H. Luckert M.A. Schmidt The suppressive effect of piroxicam on autochronous intestinal tumors in the rat Cancer Lett 21 1983 57 61
150. J.D. Potter Reconciling the epidemiology, physiology, and molecular biology of colon cancer JAMA 268 1992 1573 1577
151. S.M. Powell G.M. Peterson A.J. Krush Molecular diagnosis of familial adenomatous polyposis N Engl J Med 329 1993 1982 1987
152. T.P. Pretlow M.A. O'Riordan T.G. Pretlow Aberrant crypts in human colonic mucosa: Putative preneoplastic lesions J Cell Biochem 16 suppl G 1992 55 1992
153. C.V. Rao A. Rivenson B. Simi Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally, occurring plant phenolic compound Cancer Res 55 1995 259 266
154. C.V. Rao B. Simi B.S. Reddy Inhibition of dietary curcumin of azoxymethane induced ornithine decarboxylase, tyrosine, protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon Carcinogenesis 14 1993 2219 2225
155. C.V. Rao A. Rivenson M. Katicoalla Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats Cancer Res 53 1993 2502 2506
156. C. Rao K. Tokumo G. Kelloff Inhibition by dietary oltipraz of experimental intestinal carcinogenesis induced by azoxymethane in male F344 rats Carcinogenesis 12 1991 1051 1055
157. T.A. Ratko C.J. Detrisac K.V. Rao Interspecies analysis of the chemopreventive efficacy of dietary α-difluoromethylornithine Anticancer Res 10 1990 67 72
158. B.S. Reddy B.R. Lokesh Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron Molec Cell Biochem 137 1994 1 8
159. B.S. Reddy Y. Maeura Tumor promotion by dietary fat in azoxymethane-induced colon cancer: Carcinogenesis in female F-344 rats: Influence of amount and source of dietary fat J Natl Cancer Inst 72 1984 745 750
160. B.S. Reddy Y. Maeura Dose-response studies of the effect of dietary butylated hydroxyanisole on colon carcinogenesis induced by methylazoxymethane acetate in female CF1 mice J Natl Cancer Inst 72 1984 1181 1187
161. B.S. Reddy J. Nayini K. Tokumo Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with of D, L-α-difuoromethylornithine, an ornithine decarboxylase inhibitor, in diet Cancer Res 50 1990 2562 2568
162. B.S. Reddy C.V. Rao A. Rivenson Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats Carcinogenesis 14 1993 1493 1497
163. G. Rettura S.M. Levenson E. Seifter Beta-carotene prevents dimethylbenz(a)anthracene induced tumors Prasad K. Nutrition and Cancer 1984 S Karger New York 296 297
164. L. Roncucci P.D. Donato L. Carati Antioxidant vitamins or lactulose for the prevention of recurrence of colorectal adenomas Dis Colon Rectum 36 1993 227 234
165. P. Rozen Z. Fireman N. Fine Oral calcium suppresses increased rectal epithelial proliferation of persons at risk of colorectal cancer Gut 30 1989 650 655
166. M.T. Ruffin K. Krishnan E. Kraus Aspirin as a chemopreventive agent for colorectal cancer: Modulation of gut epithelial prostaglandins to a single daily dose Proc Am Assoc Cancer Res 35 1994 A1837
167. R. Sanduja D. Loose-Michell K.K. Wu Inhibition of de novo synthesis and message expression of prostaglandind H synthase by salicylates Adv Prostaglandin Thromb Leuko Res 21A 1991 149 152
168. L. Santamaria A. Bianchi-Santamaria Free radicals as carcinogens and their quenchers as anticarcinogens Med Oncol Tumor Pharmacol 8 1991 121 140
169. T.I. Sergeeva K. Khaetakii A.S. Poliahchk Preventive effect of domestic synthetic beta-carotene on the development of rat mammary tumors induced by DMBA Vopr Med Khim 38 1992 14 16
170. B.N.Y. Setty J.E. Graever M.J. Stuart The mitogenic effect of 15- and 12-hydroxyeicosatetraeinoic acid on endothelial cells may be mediated via diacylglycerol kinase inhibition J Biol Chem 262 1987 17613 17622
171. S.C. Sharma H. Muhktar S.K. Skarun Lipid peroxide formation in experimental inflammation Biochem Pharmacol 21 1972 1210 1214
172. S.J. Shiff M.I. Koutsos L. Qiao Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: Effects on cell cycle and apoptosis Exp Cell Res 222 1996 179 188
173. S.J. Shiff L. Qiao L. Tsai Sulindac sulfide, an aspirin-like compound inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells J Clin Invest 96 1995 491 503
174. G. Shklar J. Schwartz D. Triler The effectiveness of a mixture of beta-carotene, alpha-tocopherol, glutathione, and ascorbic acid for cancer prevention Nutr Cancer 20 1993 145 151
175. D. Sidransky T. Tokino S. Hamilton Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors Science 256 1992 102 105
176. J. Silverman S. Katayama K. Zelenakas Effects of retinoids on the induction of colon cancer in F344 rats by N-methyl-N-nitrosourea or by 1,2-dimethylhydrazine Carcinogenesis 2 1981 1167 1172
177. M.L. Slattery A.W. Sorenson M.H. Ford Dietary calcium intake as a mitigating factor in colon cancer Am J Epidemiol 128 1988 504 514
178. S. Som M. Chatterjee M.R. Banerjee Beta-carotene inhibition of 7, 12-dimethylbenzanthracene-induced transformation of murine mammary cells in vitro Carcinogenesis 5 1984 937 940
179. K.B. Soni R. Kuttan Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers Ind J Physio Pharmacol 36 1992 273 275
180. M.T. Spagnesi F. Tonelli P. Dolara Rectal proliferation and polyp recurrence in patients with familial adenomatous polyposis after sulindac treatment Gastroenterology 106 1994 362 366
181. L. Spirio S. Olshwang J. Groden Alleles of the APC gene: An attenuated form of familial polyposis Cell 75 1993 951 957
182. M.B. Sporn Approaches to prevention of epithelial cancer during the preneoplastic period Cancer Res 36 1976 2699 2702
183. R.C. Srimal Curcumin Drugs Future 12 1987 331 333
184. R.C. Srimal B.N. Dhawan Pharmacology of curcumin: A non-steroidal and anti-inflammatory agent J Pharm Pharmacol 25 1973 447 452
185. K.A. Steinmetz J.D. Potter Vegetables, fruit, and cancer: II. Mechanisms Cancer Causes Control 2 1991 427 442
186. H.S. Stern R.C. Gregorie H. Koshan Long-term effects of dietary calcium on risk markers for colon cancer in patients with familial polyposis Surgery 108 1990 528 533
187. G. Stoner H. Mukhtar Polyphenols as cancer chemopreventive agents J Cell Biochem 22 suppl 1995 169 1995
188. M. Subramanian M.N.A. Sreejayan-Rao T.P.A. Devasagayam Diminution of singlet oxygen induced DNA damage by curcumin and related antioxidants Mutat Res 311 1994 249 255
189. C.E. Szarka G. Grana P.F. Engstrom Chemoprevention of cancer Curr Probl Cancer 18 1994 6 78
190. H.J. Thompson A.M. Ronan Effect of D, L-2-difluoromethylornithine and endocrine manipulation on the induction of mammary carcinogenesis by 1-methyl-1-nitrosourea Carcinogenesis 7 1986 2003 2006
191. A.G. Thorson H.T. Lynch T.C. Smyrk Rectal cancer in FAP patient after sulindac Lancet 343 1994 180
192. M.J. Thun M.M. Namboodiri E.F. Calle Aspirin use and risk of fatal cancer Cancer Res 53 1993 1322 1327
193. M.J. Thun M.M. Namboodiri Heath C.W. Jr Aspirin use and reduced risk of fatal colon cancer N Engl J Med 328 1991 1593 1596
194. S. Toma P.L. Losardo M. Vincent Effectiveness of β-carotene in cancer chemoprevention Eur J Cancer Prev 4 1995 213 224
195. H.H. Tonnesen J.V. Grenehill Studies on curcumin and curcuminoids: XXII. Curcumin as a reducing agent and as a radical scavenger Int J Pharmaceut 87 1992 79 87
196. M. Tsujii R.N. DuBois Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing Cox-2 Cell 83 1995 493 501
197. P.J.M. Tutton D.H. Barkla Influence of prostaglandin analogues on epithelial cell proliferation and xenograft growth Br J Cancer 41 1980 47 51
198. V.G. Vogel R.S. McPherson Dietary epidemiology of colon cancer Hematol Oncol Clin North Am 3 1989 35 63
199. B. Vogelstein E.R. Fearon S.R. Hamilton Genetic alterations during colorectal-tumor development N Engl J Med 319 1988 525 532
200. W.R. Waddell G.F. Ganser E.J. Cerise Sulindac for polyposis of the colon Am J Surg 157 1989 175 178
201. J.M. Ward Dose response to a single injection of azoxymethane in rats Vet Pathol 12 1975 165 177
202. M.J. Wargovich V.W.S. Eng H.L. Newmark Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colonic epithelium Cancer Lett 23 1984 253 258
203. M.J. Wargovich V.W. Eng H.L. Newmark Calcium ameliorates the toxic effect of deoxycholic acid on colonic epithelium Carcinogenesis 4 1983 1205 1207
204. M.J. Wargovich C. Harris D. Chen Growth kinetics and chemoprevention of aberrant crypts in the rat colon J Cell Biochem suppl 16G 1992 51 54
205. D.M. Waterhouse K.A. Calzone C. Mele Adherence to oral tamoxifen: A comparison of patient self-report, pill counts, and microelectronic monitoring J Clin Oncol 11 1993 1189 1197
206. L.W. Wattenberg Chemoprevention of cancer Cancer Res 45 1985 1 8
207. L.W. Wattenberg M. Lipkin C. Boone Cancer Chemoprevention 1992 CRC Press Boca Raton FL
208. I.B. Weinstein Cancer prevention: Recent progress and future opportunities Cancer Res 51 suppl 1991 5080S 51991
209. J.H. Weisburger H. Marquardt H.F. Mower Inhibition of carcinogenesis: Vitamin C and the prevention of gastric cancer Prev Med 9 1980 352 361
210. C.W. Welsch J.V. DeHoog R.C. Moon Inhibition of mammary tumorigenesis in nulliparous CH3 mice by chronic feeding of the synthetic retinoid, N-(4-hydroxyphenyl) retinamide Carcinogenesis 4 1983 1185 1187
211. R.H. Whitehead J.L. Joseph Derivation of conditionally immortalized cell lines containing the Min mutation from the normal colonic mucosa and other tissues of an “Immortomouse”/Min hybrid Epithelial Cell Biol 3 1994 119 125
212. G. Winde H.G. Gumbinger H. Osswald The NSAID sulindac reverses rectal adenomas in colectomized patients with familial adenomatous polyposis: Clinical results of a dose-finding study on rectal sulindac administration Int J Colon Dis 8 1993 13 17
213. A.W. Wood Huang M.-T. R.L. Cahnge Inhibition of the mutagenticity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: Exceptional activity of ellagic acid Proc Natl Acad Sci USA 79 1982 5513 5517
214. A.H. Wu-Williams X.D. Dai W. Blot Lung cancer among women in north-east China Br J Cancer 62 1990 982 987
215. X.M. Xu A. Hajibeigi D. Loose-Mitchell Characterization of endothelial cell prostaglandin H synthase-1 (cyclooxygenase) gene [abstr] Blood 82 1993 342a
216. K. Yamada K. Yoshitake M. Sato Proliferating cell nuclear antigen in normal preneoplastic, and neoplastic colonic epithelium in the rat Gastroenterology 103 1992 160 167
217. S. Yamamoto Mammalian lipooxygenases: Molecular structures and functions Biochem Biophys Acta 1128 1992 117 131
218. W. Zheng W.J. Blot E.L. Diamond Serum micronutrients and the subsequent risk of oral and pharyngeal cancer Cancer Res 53 1993 795 798
219. R.G. Ziegler A review of epidemiologic evidence that carotenoids reduce the risk of cancer J Nutr 119 1989 116 122