Rearrangement of diflunisal acyl glucuronide into its β-glucuronidase-resistant isomers facilitates transport through the small intestine to the colon of the rat

Life Sciences

Volumn 70, Issue 1, 2001, Pages 25-36

  Dickinson, Ronald G ^a   King, Andrew R ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

glucuronidase; Acyl glucuronide; Colon cancer; Diflunisal; Rearrangement

Indexed keywords

ACYLGLUCURONIDE; BETA GLUCURONIDASE; DIFLUNISAL; DRUG METABOLITE; GLUCURONIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CECUM; COLON; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG FECES LEVEL; DRUG HYDROLYSIS; DRUG URINE LEVEL; ENZYME INHIBITION; HOMOGENATE; INCUBATION TIME; ISOMER; MALE; NONHUMAN; RAT; SMALL INTESTINE;

ANIMALS; ANIMALS, OUTBRED STRAINS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BIOLOGICAL TRANSPORT; COLON; DIFLUNISAL; GLUCURONIDASE; INTESTINAL ABSORPTION; INTESTINE, SMALL; MALE; MODELS, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

EID: 0035205748     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01371-6     Document Type: Article

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