Agonist-mediated down-regulation of rat β1-adrenergic receptor transcripts: Role of potential post-transcriptional degradation factors

Molecular Pharmacology

Volumn 60, Issue 6, 2001, Pages 1308-1324

  Kirigiti, P ^a   Bai, Y ^a   Yang, Y F ^a   Li, X ^a   Li, B ^a   Brewer, G ^a   Machida, C A ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; HUR PROTEIN; ISOPRENALINE; MESSENGER RNA; RNA BINDING PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; ASSAY; CONTROLLED STUDY; CROSS LINKING; GENETIC TRANSFECTION; GLIOMA CELL; HALF LIFE TIME; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PROCESSING; PROTEIN STABILITY; RAT; REACTION ANALYSIS; REACTION TIME; RECEPTOR DOWN REGULATION; REDUCTION;

EID: 0035210679     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.60.6.1308     Document Type: Article

References (40)

1. Mammalian elav-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both central and peripheral nervous systems
2. Purification and characterization of beta-adrenergic receptor mRNA-binding proteins
3. Protein ligands to HuR modulate its interaction with target mRNAs in vivo
4. An A + U rich element RNA-binding factor regulates c-myc mRNA stability in vitro
5. Assembly of the α-globin mRNA stability complex reflects binary interaction between the pyrimidine-rich 3′ untranslated region determinant and poly (C) binding protein αCP
6. 2-adrenergic receptor mRNA stability occurs via a specific AU-rich element
7. 2-adrenoceptor mRNA by agonist
8. Structural determinants in AUF1 required for high affinity binding to A+U-rich elements
9. RNA-protein interactions in the control of stability and localization of messenger RNA
10. 1-adrenergic receptor transcripts: Cloning and alterations in failing heart
11. Elav proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system
12. Deadenylation: A mechanism controlling c-fos mRNA decay
13. Agonist-induced destabilization of β-adrenergic receptor mRNAs
14. Association of heterogeneous nuclear ribonuclear protein A1 and C proteins with reiterated AUUUA sequences
15. Agonist and cyclic AMP-mediated regulation of beta 1-adrenergic receptor mRNA and gene transcription in rat C6 glioma cells
16. 2-adrenergic receptor mRNA and gene transcription in rat C6 glioma cells: Effects of agonist, forskolin, and protein synthesis inhibition
17. r 35,000 β-adrenergic receptor mRNA-binding protein induced by agonists requires both an AUUUA pentamer and U-rich domains for RNA recognition
18. Alpha 1-adrenergic receptor mRNA level is regulated by norepinephrine in rabbit smooth muscle cells
19. Cytoplasmic regulation of mRNA function: The importance of the 3′ untranslated region
20. Electrophoretic mobility shift assay for detection of DNA binding proteins recognizing beta-adrenergic receptor gene sequences
21. Rat beta 1-adrenergic receptor regulatory region containing consensus AP-2 elements recognizes novel transactivator proteins
22. Agonist-mediated destabilization of m1 muscarinic acetylcholine receptor mRNA: Elements involved in mRNA stability are localized in the 3′ untranslated region
23. Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR
24. Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element
25. Cloning and characterization of HuR, a ubiquitously expressed elav-like protein
26. An AU-rich sequence in the 3′ UTR of plasminogen activator inhibitor type 2 (PAI-2) mRNA promotes PAI-2 mRNA decay and provides a binding site for nuclear HuR
27. Agonist-mediated destabilization of human beta 1-adrenergic receptor mRNA: Role of the 3′ untranslated region
28. Insights into hormonal control of messenger RNA stability
29. Regulation of the mRNA-binding protein AUF1 by activation of the β-adrenergic receptor signal transduction pathway
30. r 35,000 protein(s) that selectively binds to β-adrenergic receptor mRNAs
31. 1-adrenergic receptor gene expression in C6 glioma cells
32. Regulation of proto-oncogene mRNA stability
33. 1-adrenergic receptor gene: Characterization of the transcript and identification of important sequence elements
34. 2-AR-binding protein and is obligate for agonist-induced destabilization of receptor mRNA
35. 2-adrenergic receptor mRNA by mutagenesis and identification of the homologous AU-rich region from different species
36. Modulation of the fate of cytoplasmic mRNA by AU-rich elements: Key sequence features controlling mRNA deadenylation and decay
37. 2c-AR mRNA impedes translation of receptor message
38. 1-adrenergc receptor RNA
39. Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein AUF1
40. The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation