Cellular and biophysical evidence for interactions between adenosine triphosphate and P-glycoprotein substrates: Functional implications for adenosine triphosphate/drug cotransport in P-glycoprotein overexpressing tumor cells and in P-glycoprotein low-level expressing erythrocytes

Blood Cells, Molecules, and Diseases

Volumn 27, Issue 1, 2001, Pages 181-200

  Abraham, Edward H ^a   Shrivastav, Brij ^b   Salikhova, Anna Y ^a   Sterling, Kenneth M ^a   Johnston, Nicholas ^a   Guidotti, Guido ^c   Scala, Stefania ^b   Litman, Thomas ^b   Chan, King C ^d   Arceci, Robert J ^e   Steiglitz, Kim ^e   Herscher, Laurie ^b   Okunieff, Paul ^f  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c HARVARD UNIVERSITY   (United States)

^d SAIC FREDERICK INC   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF ROCHESTER   (United States)

Author keywords

ABC proteins; Adriamycin; Apyrase; ATP (adenosine triphosphate); ATP transporter; Camptothecin; Capillary electrophoresis; CD39; Colchicine; Cotransport; Doxorubicin; Electrophoresis; Erythrocyte; Knockout mice; MDR (multidrug resistance protein); Pgp (P glycoprotein); Pgp drug substrates; Plasma ATP; RBC; Stoichiometry of coupling; Taxol; Verapamil

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; APYRASE; CAMPTOTHECIN; COLCHICINE; DOXORUBICIN; DRUG METABOLITE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL; SULFONYLUREA; TOXIN; VERAPAMIL;

ANIMAL CELL; ARTICLE; CAPILLARY ELECTROPHORESIS; CELL MEMBRANE; CONTROLLED STUDY; CYTOPLASM; ELECTRIC FIELD; ELECTRICITY; ERYTHROCYTE; EXTRACELLULAR SPACE; GENE OVEREXPRESSION; GENE TARGETING; KNOCKOUT MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; STOICHIOMETRY; TUMOR CELL;

MAMMALIA;

EID: 0035054299     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1006/bcmd.2000.0373     Document Type: Article

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