Toxicokinetic modelling of methyl formate exposure and implications for biological monitoring

International Archives of Occupational and Environmental Health

Volumn 73, Issue 7, 2000, Pages 479-487

  Nihlen A ^a   Droz, P O ^b  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

Author keywords

Biological monitoring; Formate; Formic acid; Human; Methanol

Indexed keywords

FORMIC ACID; FORMIC ACID DERIVATIVE; METHANOL;

ARTICLE; BIOLOGICAL MONITORING; EXPERIMENTAL MODEL; FOUNDRY; HUMAN; NORMAL HUMAN; OCCUPATIONAL EXPOSURE; TOXICOKINETICS; URINALYSIS; URINE LEVEL;

ENVIRONMENTAL MONITORING; FORMIC ACID ESTERS; FORMIC ACIDS; HUMAN; INHALATION EXPOSURE; METHANOL; MODELS, BIOLOGICAL; OCCUPATIONAL EXPOSURE; SUPPORT, NON-U.S. GOV'T;

EID: 0033813914     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004200000170     Document Type: Article

References (46)

1. 1999 TLVs and BEIs. Threshold limit values for chemical substances and physical agents. Biological exposure indices
2. Odor as an aid to chemical safety: Odor thresholds compared with threshold limit values and volatilities for 214 industrial chemicals in air and water dilution
3. Occupational exposure to methanol
4. Kinetic and structural model for the binding of formate to the rapid form of cytochrome c oxidase
5. Occupational chronic exposure to organic solvents. VI. Formic acid concentration in blood and urine as an indicator of methanol exposure
6. Urinary methanol and formic acid as indicators of occupational exposure to methyl formate
7. Dermal absorption and pharmacokinetics of isopropanol in the male and female F-344 rat
8. Formate in urine as a biological indicator of formaldehyde exposure: A review
9. Isopropanol exposure: Environmental and biological monitoring in a printing works
10. Formate in serum and urine after controlled methanol exposure at the threshold limit value
11. Toxicokinetic modeling of dose-dependent formate elimination in rats: In vivo-in vitro correlations using the perfused rat liver
12. MAK- und BAT-wertliste 1999
13. 14C]formate in normal and folate-deficient cynomolgus monkeys
14. Formate-induced alterations in retinal function in methanol-intoxicated rats
15. Anesthetic potencies of n-alkanols: Results of additivity and solubility studies suggest a mechanism of action similar to that for conventional inhaled anesthetics
16. Use of urinary formic acid as a biological exposure index of methanol exposure
17. Absence of formic acid accumulation in urine following five days of methanol exposure
18. Evaluation of methanol and formate in urine as biological exposure indices of methanol exposure
19. Metabolism of ethyl acetate in the rat: Hydrolysis of ethyl alcohol in vitro and in vivo
20. Oxidative cleavage of carboxylic esters by cytochrome P-450
21. Occupational chronic exposure to organic solvents. X. Biological monitoring parameters for methanol exposure
22. Physiologically based pharmacokinetic model for methanol in rats, monkeys, and humans
23. Metabolic interaction between endogenous methanol and exogenous ethanol studied in human volunteers by analysis of breath
24. Partition coefficients of some acetate esters and alcohols in water, blood, olive oil, and rat tissues
25. Chloride/formate exchange with formic acid recycling: A mechanism of active chloride transport across epithelial membranes
26. Methanol in urine as a biological indicator of occupational exposure to methanol vapor
27. Lack of blood formate accumulation in humans following exposure to methanol vapor at the current permissible exposure limit of 200 ppm
28. Urinary formic acid as an indicator of occupational exposure to formic acid and methanol
29. Methanol and formic acid toxicity: Biochemical mechanisms
30. Metabolism of methanol and formate in dogs
31. Enzymatic assay of formic acid and gas chromatography of methanol for urinary biological monitoring of exposure to methanol
32. Serum concentrations of methanol after inhalation at 200 ppm
33. Oxidative cleavage of esters and amides to carbonyl products by cytochrome P450
34. A pharmacokinetic model of inhaled methanol in humans and comparison to methanol disposition in mice and rats
35. Biological monitoring IV: Measurements in urine
36. Biological monitoring of persons exposed to methanol vapours
37. Neurobehavioral effects of low solvent exposures in a foundry
38. Neurobehavioral effects of experimental methyl formate exposure
39. Report of the Task group on reference man
40. Toxicology update methanol
41. Development of a physiologically based pharmacokinetic model to describe the disposition of methanol in pregnant rats and mice
42. Formic acid excretion in comparison with methanol excretion in urine of workers occupationally exposed to methanol