IL-4 differentially regulates eotaxin and MCP-4 in lung epithelium and circulating mononuclear cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 281, Issue 5 25-5, 2001, Pages

  Nakamura, Hidetoshi ^a   Luster, Andrew D ^b   Tateno, Hiroki ^c   Jedrzkiewicz, Sean ^a   Tamura, Gen ^a   Haley, Kathleen J ^a   Garcia Zepeda, Eduardo A ^b   Yamaguchi, Kazuhiro ^c   Lilly, Craig M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c KEIO UNIVERSITY   (Japan)

Author keywords

A549 cells; BEAS 2B cells; Interferon ; Interleukin 4; Interleukin 8; Monocyte chemoattractant protein 4; Peripheral blood mononuclear cells

Indexed keywords

DEXAMETHASONE; EOTAXIN; INTERLEUKIN 4; MONOCYTE CHEMOTACTIC PROTEIN 4;

ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INHIBITION KINETICS; LOWER RESPIRATORY TRACT; LUNG ALVEOLUS EPITHELIUM; MONONUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; RESPIRATORY TRACT ALLERGY;

EID: 0035198986     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.281.5.l1288     Document Type: Article

References (70)

1. Phenotyping and cytokine regulation of the BEAS-2B human bronchial epithelial cell: Demonstration of inducible expression of the adhesion molecule VCAM-1 and ICAM-1
2. Pathogenesis of allergic rhinitis
3. Cellular events in the bronchi in mild asthma and after bronchial provocation
4. Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B
5. Eosinophilic inflammation in asthma
6. Compartmentalized IL-8 and elastase release within the human lung in unilateral pneumonia
7. Elevated release of tumor necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma
8. Mycobacterial and schistosomal antigen-elicited granuloma formation in IFN-γ and IL-4 knockout mice
9. Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo
10. Interleukin-4 is required for the induction of lung Th2 mucosal immunity
11. Cloning, expression, and characterization of the human eosinophil eotaxin receptor
12. Mechanisms of IL-4-mediated suppression of IP-10 gene expression in murine macrophages
13. Human eotaxin represents a potent activator of the respiratory burst of human eosinophils
14. T cells from eosinophilic patients produce interleukin-5 with interleukin-2 stimulation
15. IL-4 down-regulates IL-1 and TNF gene expression in human monocytes
16. Identification of a mouse eosinophil receptor for the CC chemokine eotaxin
17. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3
18. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia
19. Constitutive and cytokine-stimulated expression of eotaxin by human airway smooth muscle cells
20. Monocyte chemotactic protein-4: Tissue-specific expression and signaling through CC chemokine receptor-2
21. Eosinophil recruitment to the lung in a murine model of allergic inflammation: The role of T cells, chemokines, and adhesion receptors
22. The coodinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness
23. Purification of human T and B cells by a discontinuous density gradient of percoll
24. Total eosinophil counts in the management of bronchial asthma
25. IL-1β induces eotaxin gene transcription through NF-κB
26. Interleukin-4 augments production of the third complement component by the alveolar epithelial cell line A549
27. Chemokines active on eosinophils: Potential roles in allergic inflammation
28. Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3
29. Glucocorticoid inhibition of RANTES expression in human lung epithelial cells
30. Damage of the airway epithelium and bronchial reactivity in patients with asthma
31. Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines
32. Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation
33. IL-4 attenuates the transcriptional activation of both IFN-α- and IFN-γ-induced cellular gene expression in monocytes and monocytic cell lines
34. Expression of eotaxin by human lung epithelial cells: Induction by cytokines and inhibition by glucocorticoids
35. Role of the monocyte chemoattractant protein and eotaxin subfamily of chemokines in allergic inflammation
36. Role of inflammation in nocturnal asthma
37. T cell-dependent regulation of eotaxin in antigen-induced pulmonary eosinophilia
38. Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells
39. Local allergen challenge and bronchoalveolar lavage of allergic asthmatic lungs: Description of the model and local airway inflammation
40. Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality
41. Priming of alveolar macrophages for interleukin-8 production in patients with idiopathic pulmonary fibrosis
42. Differential regulation of eotaxin expression by TNF-α and PMA in human monocytic U-937 cells
43. Eotaxin and impaired lung function in asthma
44. Interleukin-8 gene expression in human bronchial epithelial cells
45. Microphthalmia (mi) in murine mast cells: Regulation of its stimuli-mediated expression on the translational level
46. Interleukin-2 and soluble interleukin-2 receptor in bronchoalveolar lavage fluid from patients with bronchial asthma
47. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils
48. Cloning of the human eosinophil chemoattractant, eotaxin: Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils
49. Mechanisms of eosinophil recruitment
50. H2-like bronchoalveolar T-lymphocyte population in atopic asthma
51. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia
52. Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice
53. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
54. Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen
55. Disparate regulation of interleukin 8 gene expression from blood monocytes, endothelial cells, and fibroblasts by interleukin 4
56. Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines
57. Sudden-onset fatal asthma: A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa?
58. IL-4 directs the development of Th2-like helper effectors
59. Chemokine-induced eosinophil recruitment: Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin
60. 2+-mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein
61. Th1- and Th2-type cytokines regulate the expression and production production of eotaxin and RANTES by human lung fibroblasts
62. Secretion of the eosinophil-active cytokines interleukin-5, granulocyte/macrophage colony-stimulating factor and interleukin-3 by bronchoalveolar lavage CD4+ and CD8+ T cell lines in atopic asthmatics, and atopic and non-atopic controls
63. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin
64. High expression of the chemokine receptor CCR3 in human blood basophils: Role in activation by eotaxin, MCP-4, and other chemokines
65. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma: Relationship to bronchial hyperreactivity
66. Bronchoscopic evaluation of severe asthma: Persistent inflammation associated with high dose glucocorticoids
67. Effects of allergen challenge on eosinophils, eosinophil cationic protein, and granulocyte-macrophage colony-stimulating factor in mild asthma
68. Immune response and airway reactivity in wild and IL-4 knockout mice exposed to latex allergens
69. Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon γ) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects
70. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant colocalization of eotaxin mRNA to bronchial epithelial and endothelial cells