Long-term ethanol administration enhances age-dependent modulation of redox state in central and peripheral organs of rat: Protection by metadoxine

Drugs under Experimental and Clinical Research

Volumn 24, Issue 2, 1998, Pages 85-91

  Calabrese, V ^a   Randazzo, G ^a   Ragusa, N ^a   Rizza, V ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANTIOXIDANT; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LIVER PROTECTIVE AGENT; METADOXINE;

AGING; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; LUMINESCENCE; MALE; NONHUMAN; OXIDATION REDUCTION STATE; RAT;

AGING; ANIMALS; ANTIOXIDANTS; BRAIN; DRUG COMBINATIONS; ETHANOL; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; KIDNEY; LIVER; MALE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PYRIDOXINE; PYRROLIDONECARBOXYLIC ACID; RATS; RATS, WISTAR;

EID: 0031758102     PISSN: 03786501     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Halliwell B. Lipid peroxidation: its mechanism, measurement, and significance. Am. J. Clin. Nutr., 57, 715S, 1993.
2. Lieber C.S. Alcohol and the liver: 1984 update. Hepatology, 4, 1243, 1984.
3. Calabrese V., Calderone A., Ragusa N., Rizza V. Effects of metadoxine on cellular status of glutathione and of enzymatic defense system following acute ethanol intoxication in rats. Drugs Exptl. Clin. Res., XXII, 17, 1996.
4. Calabrese V., Dinotta F.S., Randazzo S.D., Rizza V. Evaluation of a lipid-soluble fraction isolated from lemon oil extract capable of inhibiting oxidative damage to the skin. J. Appl. Cosmetology, 13, 27, 1995.
5. Renis M., Calabrese V., Russo A., Calderone A., Barcellona M.L., Rizza V. Nuclear DNA strand breaks during ethanol-induced oxidative stress in rat brain. FEBS Lett., 390, 153, 1996.
6. Calabrese V., Renis M., Calderone A., Russo A., Barcellona M.L., Rizza V. Stress proteins and SH-groups in oxidant-induced cell damage after acute ethanol administration in rat. Free Radical Biol. Med., 20, 391, 1996.
7. Flecha B., Llesuy S., Boveris A. Hydroperoxide-initiated chemiluminescence: an assay for oxidative stress in biopsies of heart, liver, and muscle. Free Rad. Biol. Med., 10, 93, 1991.
8. Adams J.D., Bernhard H.L., Mitchell J.R. Plasma glutathione and glutathione disulfide in the rat. Regulation and response to oxidative stress. J. Pharmacol. Exp. Ther. 227, 749, 1983.
9. Carlberg I., Mannervik H. Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J. Biol. Chem., 250, 5475, 1975.
10. Habig W.H, Pabst M.J., Jakoby W.B. Glutathione s-transferases. J. Biol. Chem., 249, 7130, 1974.
11. Smith P., Krohn R., Hermanson G., et al. Measurement of proteins using bicinchoninic acid. Anal. Biochem., 150, 76, 1985.
12. Halliwell B., Aruoma O.I. DNA damage by oxygen-derived species: its mechanism and measurement in mammalian systems. FEBS Lett., 281, 9, 1991.
13. Halliwell B. Oxidants and human disease: some new concepts. FASEB J., 1, 358, 1987.
14. Di Luzio N.R., Hartman A.D. Role of lipid peroxidation in the pathogenesis of the ethanol-induced fatty liver. Fed. Proc. 26, 1436, 1997.