Loss of heterozygosity and heterogeneity of its appearance and persisting in the course of acute myeloid leukemia and myelodysplastic syndromes

Leukemia Research

Volumn 25, Issue 1, 2001, Pages 45-53

  Faderl, S ^a   Gidel, C ^a   Kantarjian, H M ^a   Manshouri, T ^a   Keating, M ^a   Albitar, M ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Acute myeloid leukemia; Intratumor clonal heterogeneity; Loss of heterozygosity; Myelodysplastic syndromes; Region 11p15.5; STR loci

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CHROMOSOME 11P; CLINICAL ARTICLE; DISEASE ASSOCIATION; GENETIC HETEROGENEITY; HETEROZYGOSITY LOSS; HUMAN; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ANEMIA, REFRACTORY, WITH EXCESS OF BLASTS; BASE PAIR MISMATCH; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 11; CPG ISLANDS; DNA METHYLATION; DNA REPAIR; FEMALE; FOLLOW-UP STUDIES; GENES, TUMOR SUPPRESSOR; HUMANS; INFANT; LEUKEMIA, MYELOID; LONGITUDINAL STUDIES; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; POLYMORPHISM, GENETIC; TANDEM REPEAT SEQUENCES; TELOMERE;

EID: 0035189488     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(00)00086-2     Document Type: Article

References (64)

1. Molecular themes in oncogenesis
2. Tumor suppressor genes
3. LOH at the APC/MCC gene (5Q21) in gastric cancer and preneoplastic lesions. Prognostic implications
4. Study of p53 in elderly patients with myelodysplastic syndromes by immunohistochemistry and DNA analysis
5. P53, p15INK4B, p16INK4A and p57KIP2 mutations during the progression of chronic myeloid leukemia
6. Molecular alterations in the TP53 gene of peripheral blood cells of patients with chronic myeloid leukemia
7. p53 loss and point mutations are associated with suppression of apoptosis and progression of CML into myeloid blastic crisis
8. The non-random distribution of point mutations in leukaemia and myelodysplasia - A possible pointer to their aetiology
9. No concomitant occurrence of the N-ras and p53 gene mutations in myelodysplastic syndromes
10. Correlation of N-ras point mutations with specific chromosomal abnormalities in primary myelodysplastic syndrome
11. RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML)
12. Molecular analysis of the retinoblastoma (RB1) gene in acute myeloid leukemia patients
13. Hypermethylation of E-cadherin in leukemia
14. Methylation status of the p15INK4B gene in hematopoietic progenitors and peripheral blood cells in myelodysplastic syndromes
15. Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: Potential prognostic implications
16. P15INK4b gene methylation and myelodysplastic syndromes
17. ABL1 methylation is a distinct molecular event associated with clonal evolution of chronic myeloid leukemia
18. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia
19. Hypermethylation of calcitonin gene in adult acute leukemia at diagnosis and during complete remission
20. FISH analysis of an AML-M5a with segmental rearrangements involving 11q23-MLL region
21. Detection of MLL gene self-fusions by RT-PCR and automated fluorescent DNA-fragment analysis
22. Use of dual-color interphase FISH for the detection of inv(16) in acute myeloid leukemia at diagnosis, relapse and during follow-up: A study of 23 patients
23. Quantification of residual disease in chronic myelogenous leukemia patients on interferon-alpha therapy by competitive polymerase chain reaction
24. Clinical implications of qualitative and quantitative polymerase chain reaction analysis in the monitoring of patients with chronic myelogenous leukemia
25. Simple competitive two-step RT-PCR assay to monitor minimal residual disease in CML patients after bone marrow transplantation
26. Light microscopic detection of BCR-ABL transcripts after in-cell RT-PCR: Fusion gene expression might correlate with clinical evolution of chronic myeloid leukemia
27. Quantitation of minimal residual disease in acute promyelocytic leukemia patients with t(15;17) translocation using real-time RT-PCR
28. A rapid practical RT-PCR-based approach for the detection of the PML/RAR alpha fusion transcript in acute promyelocytic leukemia
29. TEL-AML1 fusion identifies a subset of children with standard risk acute lymphoblastic leukemia who have an excellent prognosis when treated with therapy that includes a single delayed intensification
30. Rapid and sensitive minimal residual disease detection in acute leukemia by quantitative real-time RT-PCR exemplified by t(12;21) TEL-AML1 fusion transcript
31. Significantly lower relapse rate for TEL/AML1-positive ALL
32. Significance of the TEL-AML fusion gene in childhood AML
33. Deletions of the long arm of chromosome 7 in myeloid disorders: Loss of band 7q32 implies worst prognosis
34. Refinement of the commonly deleted segment in myeloid leukemia with a del (20q)
35. Nonrandom chromosomal abnormalities in acute lymphoblastic leukemia of childhood
36. Expression of recesive alleles by chromosomal mechanisms in retinoblastoma
37. A common region of loss of heterozygosity in Wilm's tumor and embryonal rhabdomyosarcoma distal to the D11S988 locus on chromosome 11p15.5
38. Frequent clonal loss of heterozygosity but scarcity of microsatellite instability at chromosomal breakpoint cluster regions in adult leukemia
39. Allelic loss in childhood acute lymphoblastic leukemia
40. Frequent loss of heterozygosity on the long arm of chromosome 6: Identification of two distinct regions of deletion in childhood acute lymphoblastic leukemia
41. High-resolution allelotype analysis of childhood B-lineage acute lymphoblastic leukemia
42. Allelic loss determination in chronic lymphocytic leukemia by immunomagnetic bead sorting and microsatellite marker analysis
43. Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias
44. Loss of heterozygosity in the chromosomal region 12p12-13 is very common in childhood acute lymphoblastic leukemia and permits the precise localization of a tumor-suppressor gene distinct from p27KIP1
45. A low rate of loss of heterozygosity is found at many different loci in childhood B-lineage acute lymphoblastic leukemia
46. Allelotype analysis of adult T-cell leukemia
47. Allelotype analysis of childhood acute lymphoblastic leukemia
48. Genomic instability of microsatellite repeats and its association wit the evolution of chronic myelogenous leukemia
49. No evidence for microsatellite instability or consistent loss of heterozygosity at selected loci in chronic myeloid leukaemia blast crisis
50. Microsatellite instability in myeloid leukemias
51. Molecular anathomy of chromosome 7q deletions in myeloid neoplasms: Evidence for multiple critical loci
52. DNA methylation and chromatin structure
53. High-density marker analysis of 11p15.5 in non-small cell lung carcinoma reveals allelic deletion of one shared and distinct region when compared to breast carcinomas
54. Loss of heterozygosity for chromosome 11 in adenocarcinoma of the stomach
55. Growth inhibition of a human lung adenocarcinoma cell line by genetic complementation with chromosome 11
56. Delineation of the centromeric and telomeric chromosome segment 11p15.5 lung cancer suppressor regions LOH11A and LOH11B
57. 11p13-15 Is a specific region of chromosomal rearrangement in gastric and esophageal adenocarcinomas
58. Definition and redefinement of chromosome 11 regions of loss of heterozygosity in breast cancer: Identification of a new region at 11q23.3
59. Development and validation of buccal swab collection methods for DNA testing for paternity testing
60. A simple salting out procedure for extracting DNA from human nucleated cells
61. A fast method for high-quality genomic DNA extraction from whole human blood
62. Chromosome band 1p36 contains a putative tumor suppressor gene important in the evolution of chronic myelocytic leukemia
63. Intraclonal heterogeneity in the in vitro daunorubicin-induced apoptosis in acute myeloid leukemia