Characterization of multidrug transporters in a normal renal tubular cell line resistant to doxorubicin - Multidrug transporters in the LLC-PK1 cell line and its resistant counterpart

Biochemical Pharmacology

Volumn 61, Issue 1, 2001, Pages 61-66

  Decorti, Giuliana ^a   Rosati, Anna ^a   Candussio, Luigi ^a   Giraldi, Tullio ^a   Bartoli Klugmann, Fiora ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Doxorubicin; LLC PK1 renal cell line; Multidrug resistance; P glycoprotein

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG TRANSPORT; KIDNEY TUBULE CELL; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SWINE;

ANIMALS; CELLS, CULTURED; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; FLUORESCENT DYES; GENE EXPRESSION; KIDNEY TUBULES, PROXIMAL; P-GLYCOPROTEIN; RHODAMINE 123; SWINE;

EID: 0035189145     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00535-9     Document Type: Article

References (30)

1. P-glycoprotein and related transporters
2. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
3. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues
4. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
5. Biochemistry of multidrug resistance mediated by the multidrug transporter
6. Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP
7. Therapeutic concentrations of cyclosporine A, but not FK506, increase P-glycoprotein expression in endothelial and renal tubule cells
8. Relationship between P-glycoprotein expression and cyclosporin A in kidney: An immunohistological and cell culture study
9. Cyclosporin A treatment induces overexpression of P-glycoprotein in the kidney and other tissues
10. The origin and characteristics of a pig kidney cell strain, LLC-PK1
11. Studies of renal cell function using cell culture techniques
12. 1 kidney epithelial cell line is mediated by both vesicle formation and P-glycoprotein drug transport
13. Handling of doxorubicin by the LLC-PK1 kidney epithelial cell line
14. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
15. Tissue distribution and disposition of daunomycin (NSC-82151) in mice: Fluorometric and isotopic methods
16. Protein measurement with the Folin phenol reagent
17. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
18. Multidrug resistance and chemosensitization: Therapeutic implications for cancer chemotherapy
19. Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies
20. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
21. Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction
22. 1) with characteristics of proximal tubular cells
23. Expression and function of P-glycoprotein in a mouse kidney cell line
24. Lysosomotropic agents increase vinblastine efflux from mouse MDR proximal kidney cells exhibiting vectorial drug transport
25. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
26. Multidrug resistance-associated protein-mediated multidrug resistance-associated modulated by cyclosporin A in a human bladder cancer cell line
27. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA
28. Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules
29. Tissue and cell distribution of the multidrug resistance-associated protein (MRP) in mouse intestine and kidney
30. Influence of intrarenal deposits of ciclosporin A on acute renal transplant rejection