Handling of doxorubicin by the LLC-PK1 kidney epithelial cell line

Journal of Pharmacology and Experimental Therapeutics

Volumn 286, Issue 1, 1998, Pages 525-530

  Decorti, Giuliana ^a,c   Peloso, Ilaria ^a   Favarin, Daniela ^a   Klugmann, Fiora Bartoli ^a   Candussio, Luigi ^a   Crivellato, Enrico ^b   Mallardi, Franco ^b   Baldini, Luciano ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIVERSITY OF UDINE   (Italy)

^c Department of Biomedical Sciences   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; CIMETIDINE; DOXORUBICIN; GLYCOPROTEIN P; PROBENECID; QUINIDINE; VANADATE SODIUM; VERAPAMIL; VINBLASTINE; VINCRISTINE;

ANIMAL CELL; ARTICLE; CATION TRANSPORT; CELL LINE; DRUG TRANSPORT; DRUG UPTAKE; KIDNEY EPITHELIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DOXORUBICIN; EPITHELIAL CELLS; KIDNEY; LLC-PK1 CELLS; P-GLYCOPROTEIN; SWINE; TEMPERATURE;

EID: 0031849697     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Bachur NR, Moore AL, Bernstein JG and Liu A (1970) Tissue distribution and disposition of daunomycin (NSC-82151) in mice: Fluorometric and isotopic methods. Cancer Chemother Rep 54:89-94.
2. Bachur NR (1971) Daunorubicinol, a major metabolite of daunorubicin: Isolation from human urine and enzymatic reactions. J Pharmacol Exp Ther 177:573-581.
3. Bachur NR and Gee M (1971) Daunorubicin metabolism by rat tissue preparations. J Pharmacol Exp Ther 177:567-572.
4. Bachur NR (1975) Adriamycin (NSC-123127) pharmacology. Cancer Treat Rep 6:153-158.
5. Burke JF (1977) Doxorubicin-hydrochloride-associated renal failure. Arch Intern Med 137:385-388.
6. Charuk JHM, Loo TW, Clarke DM and Reithmeier RAF (1994) Interaction of rat kidney P-glycoprotein with a urinary component and various drugs including cyclosporin A. Am J Physiol 266:F66-F75.
7. Coley HM, Amos WB, Twentyman PR and Workman P (1993) Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines. Br J Cancer 67: 1316-1323.
8. Cordon-Cardo C, O'Brien JP, Boccia J, Casals D, Bertino JR and Melamed MR (1990) Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J Histochem Cytochem 38:1277-1287.
9. Dalmark M and Storm HH (1981) A fickian diffusion transport process with features of transport catalysis: Doxorubicin transport in human red blood cells. J Gen Physiol 78:349-364.
10. Daoud SS and Huang KC (1988) Renal handling of adriamycin. Prog Clin Biol Res 258:161-171.
11. de Lange JH, Schipper NW, Schuurhuis GJ, ten Kate TK, van Heijningen TH, Pinedo HM, Lankelma J and Baak JP (1992) Quantification by laser scan microscopy of intracellular doxorubicin distribution. Cytometry 13:571-576.
12. Finkel FM, Knapp KT and Mulligan LT (1969) Fluorometric determination of serum levels and urinary excretion of daunomycin (NSC-82151) in mice and rats. Cancer Chemother Rep 53:159-164.
13. Frezard F and Garnier-Suillerot A (1991) Comparison of the membrane transport of anthracycline derivatives in drug-resistant and drug-sensitive K562 cells. Eur J Biochem 196:483-491.
14. Gachot B, Taue M, Morat L and Poujeol P (1991) Zinc uptake by proximal cells isolated from rabbit kidney: Effects of cysteine and histidine. Pflugers Arch Eur J Physiol 419:583-587.
15. Gottesman MM and Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62:385-427.
16. Handler JS, Perkins FM and Johnson JP (1980) Studies of renal cell function using cell culture techniques. Am J Physiol 238:F1-F9.
17. Harrigan PR, Wong KF, Redelmeier TE, Wheeler JJ and Cullis PR (1993) Accumulation of doxorubicin and other lipophilic amines into large unilamellar vesicles in response to transmembrane pH gradients. Biochim Biophys Acta 1149:329-338.
18. Hayashi Y, Imaqawa T, Kokubo T, Kurokawa Y and Takahashi M (1984) Nuclear alterations of myocardial cells and glomerular epithelial cells in rats after a single administration of adriamycin. Toxicol Lett 20:105-110.
19. Horio M, Chin K-V, Currier SJ, Goldenberg S, Williams C, Pastan I, Gottesman MM and Handler J (1989) Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia. J Biol Chem 264: 14880-14884.
20. Horio M, Pastan I, Gottesman MM and Handler JS (1990) Transepithelial transport of vinblastine by kidney-derived cell lines. Application of a new kinetic model to estimate the in situ Km of the pump. Biochim Biophys Acta 1027:116-122.
21. Horio MM, Kakihara H, Nakahama Y, Fukuhara Y, Ueda N, Orita Y, Kamada T, Pastan I and Handler J (1991) Kidney-derived cells show multidrug secretory transport, in Cellular and Molecular Biology of the Kidney (Koide H, Endou H and Kurokawa K, eds) pp 143-148, Karger, Basel.
22. Hull RN, Cherry WR and Weaver GW (1976) The origin and characteristics of a pig kidney cell strain, LLC-PK1. In Vitro 12:670-677.
23. Ito S, Woodland C, Harper PA and Koren G (1993) The mechanism of the verapamildigoxin interaction in renal tubular cells (LLC-PK1). Life Sci 53:PL399-PL403.
24. Kane SE (1996) Multidrug resistance of cancer cells, in Advances in Drug Research (Testa B and Meyer UA, eds) vol 28, pp 181-252, Academic Press Ltd., London.
25. Kastner S, Wilks MF, Gwinner W, Soose M, Bach PH and Stolte H (1990) Metabolic heterogeneity of isolated cortical and juxtamedullary glomeruli in adriamycin nephropathy. Renal Physiol Biochem 14:48-54.
26. Kastner S, Wilks MF, Soose M, Bach PH and Stolte H (1991) Metabolic studies on isolated glomeruli: a valuable tool to investigate glomerular damage, in Nephrotoxicity: Mechanisms, Early Diagnosis and Therapeutic Management (Bach PH, Gregg NJ, Wilks MW and Delacruz L, eds) pp 467-474, Marcel Dekker, New York.
27. Koren G, Beauty K, Seto A, Einarson TR and Lishner M (1992) The effects of impaired liver function on the elimination of antineoplastic agents. Ann Pharmacother 26:363-371.
28. Krarup-Hansen A, Wassermann K, Rasmussen SN and Dalmark M (1988) Pharmacokinetics of doxorubicin in man with induced acid or alkaline urine. Acta Oncol 27:25-30.
29. Landwehr DM, Carvalho JS and Oken DE (1977) Micropuncture studies of the filtration and absorption of albumin by nephrotic rats. Kidney Int 11:9-17.
30. Lowry OH, Rosebrough NJ, Farr AL and Randell RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
31. Madden TD and Redelmeier TE (1994) Transmembrane distribution of lipophilie cations in response to an electrochemical potential in reconstituted cytochrome e oxidase vesicles and in vesicles exhibiting a potassium ion diffusion potential. J Bioenerg Biomembrane 26:221-230.
32. Nelson JA (1988) A physiological function for multidrug-resistant membrane glycoproteins: a hypothesis regarding the renal organic cation secretory system. Cancer Chemother Pharmacol 22:92-93.
33. Pan BF, Dutt A and Nelson JA (1994) Enhanced transepithelial flux of cimetidine by Madin-Darby canine kidney cells overexpressing human P-glyeoprotein. J Pharmacol Exp Ther 270:1-7.
34. Pastan I, Gottesman MM, Ueda K, Lovelace E, Rutherford AV and Willingham MC (1988) A retrovirus carrying a MDRl cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc Natl Acad Sci USA 85:4486-4490.
35. Pinto-do-Ó PC and Soares-da-Silva P (1996) Studies on the pharmacology of the inward transport of L-DOPA in rat renal tubules. Br J Pharmacol 118:741-747.
36. Pratt WB and Ruddon RW (1979) The Anticancer Drugs. Oxford University Press, Inc., New York.
37. Rutherford AV and Willingham MC (1993) Ultrastructural localization of daunomycin in multidrug-resistant cultured cells with modulation of the multidrug transporter. J Histochem Cytochem 41:1573-1577.
38. Saeki T, Ueda K, Tanigawara Y, Hori R and Komano T (1993a) Human P-glycoprotein transports cyclosporin A and FK506. J Biol Chem 268:6077-6080.
39. Saeki T, Ueda K, Tanigawara Y, Hori R and Komano T (1993b) P-glycoprotein-mediated transcellular transport of MDR-reversing agents. FEBS Lett 324:99-102.
40. Saito H, Inui K-I and Hori R (1986) Mechanisms of gentamicin transport in kidney epithelial cell line (LLC-PK1). J Pharmacol Exp Ther 238:1071-1076.
41. Schömig E, Babin-Ebell J and Russ H (1993) 1,1′-diethyl-2,2′cyanine (Decynium 22) potently inhibits the renal transport of organic cations. Naunyn-Schmiedebergs Arch Pharmacol 347:379-383.
42. Simon SM and Schindler M (1994) Cell biological mechanisms of multidrug resistance in tumors. Proc Natl Acad Sci USA 91:3497-3504.
43. Sugawara I, Kataoka I, Morishita T, Hamada H, Tsuruo T, Itoyama S and Mori S (1988) Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16. Cancer Res 48:1926-1929.
44. Takano M, Kato M, Takayama A, Yasuhara M, Inui K and Hori R (1992) Transport of procainamide in a kidney epithelial cell line LLC-PK1. Biochim Biophys Acta 1108:133-139.
45. Tanaka K, Hirai M, Tanigawara Y, Ueda K, Takano M, Hori R and Inui K (1997) Relationship between expression level of P-glycoprotein and daunorubicin transport in LLC-PK1 cells transfected with human MDR1 gene. Biochem Pharmacol 53:741-746.
46. Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I and Willingham MC (1987) Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA 84:7735-7738.
47. Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I and Willingham MC (1989) Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J Histochem Cytochem 37:159-164.
48. Tsuruo T (1991) Reversal of multidrug resistance by calcium channel blockers and other agents, in Molecular and Cellular Biology of Multidrug Resistance In Tumor Cells (Roninson IB, ed) pp 349-372, Plenum, New York.
49. Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T and Hori R (1992) Human P-glycoprotein transports cortisol, aldosterone and dexamethasone, but not progesterone. J Biol Chem 267:24248-24252.