Cell cycle phase specificity in the potentiation of etoposide-induced DNA damage and apoptosis by KN-62, an inhibitor of calcium-calmodulin-dependent enzymes

Biochemical Pharmacology

Volumn 61, Issue 1, 2001, Pages 49-54

  Aoyama, Masako ^a   Grabowski, Dale R ^a   Holmes, Katherine A ^a   Rybicki, Lisa A ^a   Bukowski, Ronald M ^a   Ganapathi, Mahrukh K ^a   Ganapathi, Ram ^a  

^a TAUSSIG CANCER INSTITUTE   (United States)

Author keywords

Apoptosis; Calcium calmodulin; Drug resistance; Etoposide; Topoisomerase II

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; DNA TOPOISOMERASE (ATP HYDROLYSING); ENZYME INHIBITOR; ETOPOSIDE; PROTEIN KINASE (CALCIUM,CALMODULIN);

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL CYCLE; DNA; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; DRUG SYNERGISM; ENZYME INHIBITORS; ETOPOSIDE; HL-60 CELLS; HUMANS;

EID: 0035187710     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00539-6     Document Type: Article

References (17)

1. Structure and function of type II DNA topoisomerases
2. DNA topoisomerases
3. DNA topoisomerases: Essential enzymes and lethal targets
4. DNA topoisomerases as anticancer drug targets
5. Eukaryotic DNA topoisomerase IIβ
6. Differences between normal and ras-transformed NIH-3T3 cells in expression of the 170kD and 180kD forms of topoisomerase II
7. Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells
8. Absence of topoisomerase IIβ in an amsacrine-resistant human leukemia cell line with mutant topoisomerase IIα
9. Drug sensitivity and sequence specificity of human recombinant DNA topoisomerases IIα (p170) and IIβ (p180)
10. Role of topoisomerase IIβ in the resistance of 9-OH-ellipticine-resistant Chinese hamster fibroblasts to topoisomerase II inhibitors
11. Altered drug interaction and regulation of topoisomerase IIβ: Potential mechanisms governing sensitivity of HL-60 cells to amsacrine and etoposide
12. Resistance to etoposide in human leukemia HL-60 cells: Reduction in drug-induced DNA cleavage associated with hypophosphorylation of topoisomerase II phosphopeptides
13. Cellular events involved in the sensitization of etoposide-resistant cells by inhibitors of calcium-calmodulin-dependent processes. Role for effects on apoptosis, DNA cleavable complex, and phosphorylation
14. Quality control of centrifugal elutriation for studies of cell cycle regulations
15. Altered expression and activity of topoisomerases during all-trans retinoic acid-induced differentiation of HL-60 cells
16. Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlative with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIα
17. Tumor cell resistance to topoisomerase II poisons. Role for intracellular calcium in the sensitization by inhibitors of calcium-calmodulin-dependent enzymes