Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlated with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIα

Biochemical Journal

Volumn 336, Issue 3, 1998, Pages 727-733

  Aoyama, Masako ^a   Grabowski, Dale R ^a   Dubyak, George R ^b   Constantinou, Andreas I ^c   Rybicki, Lisa A ^a   Bukowski, Ronald M ^a   Ganapathi, Mahrukh K ^a   Hickson, Ian D ^d   Ganapathi, Ram ^a  

^a TAUSSIG CANCER INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ILLINOIS   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMSACRINE; BUFFER; CALCIUM ION; DIAMINE DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; ETOPOSIDE; HEAVY METAL; KINETOPLAST DNA; MAGNESIUM;

ARTICLE; ATTENUATION; CALCIUM CELL LEVEL; CELL STRAIN HL 60; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; DNA CLEAVAGE; DNA DAMAGE; DRUG CYTOTOXICITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0032535434     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3360727     Document Type: Article

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