Tumor cell resistance to topoisomerase II poisons. Role for intracellular free calcium in the sensitization by inhibitors of calcium-calmodulin-dependent enzymes

Biochemical Pharmacology

Volumn 56, Issue 3, 1998, Pages 345-349

  Grabowski, Dale R ^a   Dubyak, George R ^b   Rybicki, Lisa ^a   Hidaka, Hiroyoshi ^c   Ganapathi, Ram ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Calcium calmodulin dependent enzyme inhibitors; Etoposide resistance; Human leukemia cells; Intracellular calcium transients; Multidrug resistance; Topoisomerase II

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; ETOPOSIDE; GLYCOPROTEIN P;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL LINE; CONTROLLED STUDY; DNA CLEAVAGE; DRUG RESISTANCE; DRUG SENSITIZATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR CELL;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; DRUG RESISTANCE, NEOPLASM; EGTAZIC ACID; ENZYME INHIBITORS; ETOPOSIDE; HL-60 CELLS; HUMANS;

EID: 0031666629     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00159-2     Document Type: Article

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