Role of LIM domains in mediating signaling protein interactions

IUBMB Life

Volumn 51, Issue 6, 2001, Pages 359-364

  Brown, S ^a   Coghill, I D ^a   McGrath, M J ^a   Robinson, P A ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Cytoskeleton; LIM domains; Phosphatases; Protein kinase C; Signal transduction; Tyrosine kinases

Indexed keywords

CELL PROTEIN; CYTOSKELETON PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

CLASSIFICATION; ENZYME BINDING; HUMAN; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

ACTINS; CONSENSUS SEQUENCE; CYTOSKELETAL PROTEINS; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 0035184995     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/152165401753366113     Document Type: Review

References (40)

1. Protein-protein interactions define specificity in signal transduction
2. LIM domains: Multiple roles as adapters and functional modifiers in protein interactions
3. Zinc fingers are sticking together
4. The LIM domain is a modular protein-binding interface
5. DeLIMiting development
6. The LIM domain: Regulation by association
7. The cysteine-rich LIM domains inhibit DNA binding by the associated homeodomain in Is1-1
8. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
9. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
10. MLP-deficienct mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy and heart failure
11. CRP1, a LIM domain protein implicated in muscle differentiation, interacts with a α-actinin
12. The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of betaI-spectrin
13. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD
14. A family of LIMonly transcriptional coactivators: Tissue-specific expression and selective activation of CREB and CREM
15. Characterization of two isoforms of the skeletal muscle LIM protein 1
16. Mutations in Lmxlb cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome
17. LIM-kinase 1 hemizygosity implicated in impaired visuospatial constructive cognition
18. The rhombotin family of cysteine-rich LIM domain oncogenes: Distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13
19. The oncogenic cysteine-rich LIM-domain protein Rbtn2 is essential for erythroid development
20. The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation
21. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells
22. Nck-2, a novel Src homology 2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase signaling pathways
23. Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding
24. Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin
25. The LIM/double zinc-finger motif functions as a protein dimerization domain
26. Zyxin and cCRP: Two interactive LIM domain proteins associated with the cytoskeleton
27. The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein
28. Mitogenic signaling by Ret/ptc2 requires association with Enigma via a LIM domain
29. LIM domain recognition of a tyrosine-containing tight turn
30. Specificity of LIM domain interactions with receptor tyrosine kinases
31. Protein-protein interaction of zinc finger LIM domains with protein kinase C
32. Protein kinase C: Structure, function and regulation
33. Localization of protein kinases by anchoring proteins: A theme in signal transduction
34. Targeting of zyxin to sites of actin membrane interaction and to the nucleus
35. Intact LIM 3 and LIM 4 domains of paxillin are required for the association to a novel polyproline region (Pro 2) of protein-tyrosine phosphatase-PEST
36. The noncatalytic domain of protein-tyrosine phosphatase-PEST targets paxillin for dephosphorylation in vivo
37. The N-terminal LIM domain negatively regulates the kinase activity of LIM-kinase 1
38. PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL
39. The PDZ domain of the LIM protein Enigma binds to Β-tropomyosin